| 13.92598 % | Redmile Group, LLC | 15,666,731 | 0 | |
| 9.30469 % | Prosight Capital | 10,467,771 | 924,767 | |
| 7.70719 % | HPWH TH AG | 8,670,588 | -1,118,356 | |
| 6.90103 % | Point72 Asset Management, L.P. | 7,763,658 | 7,763,658 | |
| 5.25098 % | OrbiMed Advisors, LLC | 5,907,351 | -61,100 | |
| 3.60498 % | BlackRock Institutional Trust Company, N.A. | 4,055,608 | -442,919 | |
| 3.57068 % | Oaktree Capital Management, L.P. | 4,017,013 | 4,017,013 | |
| 3.56552 % | AstraZeneca (UK) Ltd. | 4,011,215 | 0 | |
| 2.65940 % | Morgan Stanley & Co. LLC | 2,991,824 | 33,760 | |
| 2.51810 % | Heights Capital Management, Inc. | 2,832,861 | 2,832,861 | |
| 2.01448 % | Nantahala Capital Management, LLC | 2,266,289 | 2,266,289 | |
| 1.98330 % | Auven Therapeutics General LP | 2,231,210 | -4,099,338 | |
| 1.95472 % | BofA Global Research (US) | 2,199,059 | 397,905 | |
| 1.40251 % | Squarer (Ron R) | 1,577,823 | 24,816 | |
| 1.37490 % | Mallik (Ameet) | 1,546,760 | -26,758 | |
| 1.34889 % | Goldman Sachs & Company, Inc. | 1,517,500 | -45,079 | |
| 1.23312 % | Platinum Asset Management | 1,387,265 | -650,822 | |
| 1.09731 % | State Street Global Advisors (US) | 1,234,473 | 23,127 | |
| 0.99409 % | Wild (Hans-Peter) | 1,118,356 | 1,118,356 | |
| 0.76337 % | Geode Capital Management, L.L.C. | 858,796 | -110,951 | |
| 0.74924 % | Woodline Partners LP | 842,900 | 27,369 | |
| 0.65206 % | Blue Owl Capital Holdings LP | 733,568 | 0 | |
| 0.60902 % | UBS Switzerland AG | 685,143 | 161,218 | |
| 0.60711 % | Vantage Consulting Group, Inc. | 682,998 | -167,739 | |
| 0.57096 % | Zaki (Mohamed) | 642,332 | 216,111 | |
| 0.53137 % | BNP Paribas Securities Corp. North America | 597,792 | -94,286 | |
| 0.49824 % | The Vanguard Group, Inc. | 560,523 | -91,484 | |
| 0.36831 % | Northern Trust Investments, Inc. | 414,348 | -68,018 | |
| 0.35983 % | Carmona (Jose) | 404,809 | 2,084 | |
| 0.34104 % | Millennium Management LLC | 383,674 | 218,857 | |
| 0.32093 % | Graham (Peter J) | 361,042 | -47,500 | |
| 0.31812 % | Corient Private Wealth LLC | 357,880 | 357,880 | |
| 0.25181 % | StemPoint Capital LP | 283,286 | 283,286 | |
| 0.24121 % | PanAgora Asset Management Inc. | 271,359 | 217,173 | |
| 0.20889 % | Abaris Investment Management AG | 235,000 | -235,000 | |
| 0.20412 % | BlackRock Investment Management, LLC | 229,635 | 13,301 | |
| 0.17099 % | BlackRock Financial Management, Inc. | 192,359 | -4,801 | |
| 0.16179 % | Charles Schwab Investment Management, Inc. | 182,012 | -12,246 | |
| 0.16044 % | Hug (Peter) | 180,500 | 37,856 | |
| 0.15458 % | Pfisterer (Thomas) | 173,899 | -451,857 | |
| 0.12661 % | UBS Financial Services, Inc. | 142,432 | -100,707 | |
| 0.12505 % | Barclays Bank PLC | 140,676 | 39,642 | |
| 0.12496 % | AQR Capital Management, LLC | 140,580 | -60,590 | |
| 0.11998 % | Monges (Viviane) | 134,980 | 37,416 | |
| 0.11753 % | Invesco Advisers, Inc. | 132,218 | -486 | |
| 0.11721 % | Fidelity Management & Research Company LLC | 131,865 | -4,551 | |
| 0.10852 % | Dafna Capital Management, LLC | 122,081 | -102,000 | |
| 0.10243 % | Susquehanna International Group, LLP | 115,232 | 11,452 | |
| 0.10197 % | BNY Mellon Asset Management | 114,719 | 1,142 | |
| 0.10044 % | The Sanibel Captiva Trust Company | 113,000 | 0 | |
| 0.09121 % | Rhumbline Advisers Ltd. Partnership | 102,608 | -9,021 | |
| 0.08889 % | Bryn Mawr Trust Company | 100,000 | 0 | |
| 0.08835 % | Sandor (Victor) | 99,398 | 27,400 | |
| 0.08527 % | Nuveen LLC | 95,926 | -33,132 | |
| 0.07895 % | Bizzari (Jean-Pierre) | 88,816 | 27,400 | |
| 0.06924 % | Kallebo (Lisa Michelle) | 77,897 | 41,900 | |
| 0.05293 % | Virtu Americas LLC | 59,548 | 59,548 | |
| 0.04912 % | Azelby (Robert W) | 55,259 | 27,400 | |
| 0.04877 % | DWS Investments UK Limited | 54,866 | 0 | |
| 0.04695 % | Morgan Stanley Smith Barney LLC | 52,817 | 12,405 | |
| 0.04408 % | AllianceBernstein L.P. | 49,590 | 27,570 | |
| 0.04002 % | MetLife Investment Management, LLC | 45,027 | -460 | |
| 0.04000 % | LPL Financial LLC | 45,000 | 20,000 | |
| 0.03888 % | Aperio Group, LLC | 43,741 | 43,266 | |
| 0.03859 % | Mellon Investments Corporation | 43,416 | -2,473 | |
| 0.03556 % | Coughlin (Timothy P) | 40,000 | 40,000 | |
| 0.03541 % | Corebridge Financial Inc. | 39,838 | -592 | |
| 0.03523 % | Mirae Asset Global Investments (USA) LLC | 39,633 | -8,930 | |
| 0.03475 % | Magnetar Capital Partners LP | 39,092 | -16,670 | |
| 0.03366 % | Ethic Inc. | 37,862 | 37,862 | |
| 0.03354 % | HRT Financial LP | 37,730 | 37,730 | |
| 0.03328 % | Wells Fargo Bank, N.A. | 37,441 | -5,336 | |
| 0.03308 % | T. Rowe Price International Ltd | 37,213 | 1,002 | |
| 0.03216 % | INTECH Investment Management LLC | 36,181 | -26,691 | |
| 0.03200 % | Creative Planning, Inc. | 35,999 | 35,999 | |
| 0.03043 % | JPMorgan Private Bank (United States) | 34,235 | -4,222 | |
| 0.02578 % | Citadel Advisors LLC | 29,006 | 29,006 | |
| 0.02390 % | Squarepoint Capital LLP | 26,883 | -64,990 | |
| 0.02319 % | Citi Investment Research (US) | 26,090 | -31,556 | |
| 0.02288 % | Manulife Investment Management (North America) Limited | 25,740 | -3,955 | |
| 0.02249 % | DLK Investment Management, LLC | 25,305 | -1,500 | |
| 0.02231 % | Goldman Sachs Asset Management, L.P. | 25,102 | 4,569 | |
| 0.02222 % | Wells Fargo Advisors | 25,000 | 0 | |
| 0.02205 % | Russell Investments Trust Company | 24,801 | -14,887 | |
| 0.02185 % | Commonwealth Financial Network | 24,577 | -14,734 | |
| 0.02179 % | Evans-Freke Stephen R | 24,509 | -40 | |
| 0.02158 % | Metropolitan Life Insurance Co. (US) | 24,279 | 0 | |
| 0.02113 % | Saxony Capital Management, LLC | 23,768 | 1,480 | |
| 0.02043 % | SEI Investments Management Corporation | 22,989 | 0 | |
| 0.02043 % | Nuveen Asset Management, LLC | 22,989 | 0 | |
| 0.02028 % | Police and Firemen's Retirement System of New Jersey | 22,819 | 0 | |
| 0.01948 % | Voya Investment Management LLC | 21,911 | -362 | |
| 0.01804 % | IEQ Capital LLC | 20,300 | -2,625 | |
| 0.01320 % | ProShare Advisors LLC | 14,855 | -2,750 | |
| 0.01255 % | Diversified Trust Company | 14,115 | 0 | |
| 0.01136 % | Tower Research Capital LLC | 12,779 | 2,645 | |
| 0.01114 % | Northern Trust Global Investments | 12,538 | -1,240 | |
| 0.01104 % | Vaughan Nelson Investment Management, L.P. | 12,425 | 0 | |
| 0.01055 % | Osaic Holdings, Inc. | 11,872 | -128 | |
| 0.00998 % | Wealth Enhancement Advisory Services, LLC | 11,232 | -3,758 | |