| 14.81957 % | Fidelity Management & Research Company LLC | 14,998,889 | 608,650 | |
| 9.73601 % | Polaris Venture Partners | 9,853,817 | 0 | |
| 6.11163 % | BlackRock Institutional Trust Company, N.A. | 6,185,577 | -228,852 | |
| 5.91612 % | The Vanguard Group, Inc. | 5,987,704 | -65,337 | |
| 5.51310 % | Rosenthal (Arnon) | 5,579,811 | 137,125 | |
| 4.77336 % | T. Rowe Price Associates, Inc. | 4,831,120 | 4,188,846 | |
| 3.50333 % | Merck & Co Inc | 3,545,719 | 0 | |
| 2.14444 % | Acadian Asset Management LLC | 2,170,388 | 729,727 | |
| 1.96233 % | Eversept Partners, LP | 1,986,072 | 1,368,654 | |
| 1.95837 % | Geode Capital Management, L.L.C. | 1,982,068 | 19,970 | |
| 1.70292 % | Adar1 Capital Management LLC | 1,723,526 | 1,343,196 | |
| 1.68946 % | State Street Global Advisors (US) | 1,709,902 | 69,640 | |
| 1.38300 % | BlackRock Financial Management, Inc. | 1,399,735 | -10,911 | |
| 1.30707 % | Jacobs Levy Equity Management, Inc. | 1,322,882 | -11,150 | |
| 1.29222 % | Euclidean Capital, L.L.C. | 1,307,858 | 0 | |
| 1.23985 % | Renaissance Technologies LLC | 1,254,850 | 220,995 | |
| 1.04258 % | Deerfield Management Company, L.P. | 1,055,192 | 0 | |
| 0.98394 % | 5AM Ventures | 995,841 | 0 | |
| 0.97628 % | DWS Investments UK Limited | 988,089 | -111,800 | |
| 0.96531 % | Vestal Point Capital, LP | 976,992 | 472,452 | |
| 0.90201 % | Dafna Capital Management, LLC | 912,928 | 0 | |
| 0.88924 % | Ikarian Capital LLC | 900,000 | -50,000 | |
| 0.83542 % | Sio Capital Management, LLC | 845,531 | 8,372 | |
| 0.71292 % | DWS Investment GmbH | 721,551 | 0 | |
| 0.64395 % | TD Asset Management Inc. | 651,738 | 540,000 | |
| 0.63991 % | Charles Schwab Investment Management, Inc. | 647,653 | 22,923 | |
| 0.63546 % | Northern Trust Investments, Inc. | 643,150 | -40,711 | |
| 0.59198 % | Two Sigma Investments, LP | 599,139 | -8,186 | |
| 0.54522 % | Citadel Advisors LLC | 551,820 | 546,382 | |
| 0.52918 % | Morgan Stanley & Co. LLC | 535,582 | 257,900 | |
| 0.52781 % | D. E. Shaw & Co., L.P. | 534,200 | 64,899 | |
| 0.51050 % | PanAgora Asset Management Inc. | 516,680 | 150,135 | |
| 0.45338 % | Boothbay Fund Management, LLC | 458,863 | 184,503 | |
| 0.40589 % | Millennium Management LLC | 410,803 | 145,987 | |
| 0.40176 % | AQR Capital Management, LLC | 406,618 | -85,974 | |
| 0.37875 % | Dimensional Fund Advisors, L.P. | 383,331 | -106,003 | |
| 0.35808 % | Berkley (Neil Lindsay) | 362,412 | 362,412 | |
| 0.35736 % | RBC Dominion Securities, Inc. | 361,689 | 361,689 | |
| 0.33980 % | BofA Global Research (US) | 343,909 | 5,927 | |
| 0.33551 % | New Leaf Venture Partners LLC | 339,569 | 0 | |
| 0.31506 % | BlackRock Investment Management, LLC | 318,872 | 87,313 | |
| 0.30983 % | Manulife Investment Management (North America) Limited | 313,578 | 189,686 | |
| 0.27116 % | Mackenzie Investments | 274,442 | 231,496 | |
| 0.26302 % | Walleye Capital LLC | 266,204 | -39,397 | |
| 0.26284 % | Diadema Partners LP | 266,023 | -190,523 | |
| 0.25172 % | Goldman Sachs & Company, Inc. | 254,765 | 38,509 | |
| 0.20136 % | Susquehanna International Group, LLP | 203,798 | -49,321 | |
| 0.19761 % | ACCI Capital Investments SGIIC, SA | 200,000 | 0 | |
| 0.19446 % | State of Wyoming | 196,814 | 196,814 | |
| 0.17376 % | Alphabet, Inc. | 175,866 | 0 | |
| 0.17357 % | BNY Mellon Asset Management | 175,666 | 416 | |
| 0.16777 % | Barclays Bank PLC | 169,795 | 44,709 | |
| 0.16519 % | Medici Capital LLC | 167,191 | 0 | |
| 0.15422 % | Kenkare-Mitra (Saraswati) | 156,083 | 54,725 | |
| 0.15234 % | Nuveen LLC | 154,188 | -31,429 | |
| 0.15008 % | Los Angeles Capital Management LLC | 151,896 | 7,600 | |
| 0.14887 % | GSA Capital Partners LLP | 150,669 | 150,669 | |
| 0.12505 % | Rhumbline Advisers Ltd. Partnership | 126,568 | 9,933 | |
| 0.12258 % | McGuire (Terrance G) | 124,060 | 95,314 | |
| 0.11828 % | Goldman Sachs Asset Management, L.P. | 119,712 | 23,823 | |
| 0.11363 % | Bridgeway Capital Management, LLC | 115,000 | 115,000 | |
| 0.11128 % | Romano (Gary) | 112,627 | -96,523 | |
| 0.10908 % | State Teachers Retirement System of Ohio | 110,400 | 7,800 | |
| 0.10805 % | Grace (Wong-Sarad) | 109,358 | 109,358 | |
| 0.10084 % | Conestoga Capital Advisors, LLC | 102,057 | -981 | |
| 0.09880 % | Deka Vermögensmanagement GmbH | 100,000 | 0 | |
| 0.09880 % | Deka Investment GmbH | 100,000 | 74,900 | |
| 0.09209 % | Mellon Investments Corporation | 93,206 | 18,962 | |
| 0.09183 % | AllianceBernstein L.P. | 92,940 | 10,840 | |
| 0.08966 % | Invesco Capital Management LLC | 90,745 | 28,747 | |
| 0.08404 % | Invesco Advisers, Inc. | 85,056 | -1,522 | |
| 0.07937 % | Wehner (David M) | 80,330 | -8,750 | |
| 0.07406 % | Lavigne (Louis J JR) | 74,961 | 28,700 | |
| 0.07246 % | XTX Markets LLC | 73,338 | 40,767 | |
| 0.06993 % | Susquehanna Fundamental Investments, LLC | 70,778 | -67,126 | |
| 0.06364 % | Garofalo (Elizabeth Amy M.D.) | 64,409 | 28,700 | |
| 0.06078 % | Cannell & Spears LLC | 61,513 | -100 | |
| 0.06037 % | Persistent Asset Partners Limited | 61,096 | -43,831 | |
| 0.05969 % | Yaffe (Kristine) | 60,409 | 27,700 | |
| 0.05925 % | BlackRock Advisors (UK) Limited | 59,969 | 9,397 | |
| 0.05829 % | IEQ Capital LLC | 58,998 | -21,408 | |
| 0.05726 % | Parametric Portfolio Associates LLC | 57,956 | 41,863 | |
| 0.05573 % | Scheller (Richard H) | 56,407 | 28,700 | |
| 0.05434 % | Velan Capital Investment Management LP | 55,000 | 0 | |
| 0.05326 % | Hammond (Paula) | 53,909 | 28,700 | |
| 0.05247 % | Baillie Gifford Overseas Ltd. | 53,106 | 0 | |
| 0.05175 % | BMO Family Office, LLC | 52,380 | 52,380 | |
| 0.05147 % | Vanguard Personalized Indexing Management, LLC | 52,095 | 17,170 | |
| 0.05108 % | HSBC Global Asset Management (UK) Limited | 51,700 | -6,372 | |
| 0.05082 % | Utah Retirement Systems | 51,430 | 0 | |
| 0.04997 % | BlackRock Asset Management Ireland Limited | 50,572 | -137,266 | |
| 0.04974 % | Wells Fargo Bank, N.A. | 50,344 | 11,166 | |
| 0.04955 % | Mirae Asset Global Investments (USA) LLC | 50,149 | -27,815 | |
| 0.04887 % | Citi Investment Research (US) | 49,461 | -13,295 | |
| 0.04477 % | Grasso (Marc) | 45,312 | -16,488 | |
| 0.04393 % | Algert Global LLC | 44,460 | 0 | |
| 0.04362 % | T. Rowe Price International Ltd | 44,144 | 10,105 | |
| 0.04284 % | BlackRock Fund Advisors | 43,361 | 0 | |
| 0.04161 % | UBS Asset Management (Americas) LLC | 42,113 | 0 | |
| 0.04139 % | UBS Financial Services, Inc. | 41,893 | -41,153 | |