| 10.14042 % | Morningside Venture Investments, Ltd. | 12,806,342 | 0 | |
| 9.67790 % | Avoro Capital Advisors LLC | 12,222,222 | 0 | |
| 9.41944 % | EcoR1 Capital, LLC | 11,895,808 | 0 | |
| 8.02725 % | The Vanguard Group, Inc. | 10,137,616 | 24,395 | |
| 7.10821 % | Wellington Management Company, LLP | 8,976,962 | -3,326,290 | |
| 5.99724 % | Morgan Stanley & Co. LLC | 7,573,910 | -524,462 | |
| 5.54280 % | Deep Track Capital LP | 7,000,000 | 0 | |
| 4.73229 % | AQR Capital Management, LLC | 5,976,414 | 1,898,995 | |
| 4.33661 % | BlackRock Institutional Trust Company, N.A. | 5,476,703 | 49,973 | |
| 3.74955 % | UBS Financial Services, Inc. | 4,735,311 | 1,463,117 | |
| 2.82106 % | State Street Global Advisors (US) | 3,562,721 | -378,684 | |
| 2.27888 % | Suvretta Capital Management, LLC | 2,878,000 | 1,231,385 | |
| 2.14177 % | Marshall Wace LLP | 2,704,837 | 2,681,263 | |
| 2.10771 % | Jennison Associates LLC | 2,661,823 | 184,292 | |
| 2.04165 % | Invus Public Equities Advisors, LLC | 2,578,396 | 0 | |
| 1.87444 % | Norges Bank Investment Management (NBIM) | 2,367,224 | 1,280,981 | |
| 1.82150 % | BofA Global Research (US) | 2,300,367 | -709,809 | |
| 1.57991 % | Geode Capital Management, L.L.C. | 1,995,271 | 45,225 | |
| 1.54607 % | Morgan Stanley Investment Management Inc. (US) | 1,952,537 | 520,236 | |
| 1.27843 % | Francois (Cedric) | 1,614,532 | -84,090 | |
| 1.27018 % | Amundi Asset Management, SAS | 1,604,105 | 1,274,523 | |
| 1.17373 % | OrbiMed Advisors, LLC | 1,482,300 | 50,000 | |
| 1.07069 % | Polar Capital LLP | 1,352,175 | -225,000 | |
| 1.04521 % | DWS Investment GmbH | 1,320,000 | -268,864 | |
| 1.02816 % | BNP Paribas Securities Corp. North America | 1,298,459 | 187,750 | |
| 0.88811 % | Deschatelets (Pascal) | 1,121,591 | 12,780 | |
| 0.88767 % | Braidwell LP | 1,121,034 | -531,300 | |
| 0.82467 % | Wells Fargo Bank, N.A. | 1,041,471 | 1,041,464 | |
| 0.80016 % | Machiels (Alec) | 1,010,516 | -5,988 | |
| 0.78323 % | Charles Schwab Investment Management, Inc. | 989,143 | 24,644 | |
| 0.71542 % | Octagon Capital Advisors LP | 903,500 | -1,190,500 | |
| 0.67305 % | Camber Capital Management LP | 850,000 | 850,000 | |
| 0.59400 % | Columbia Threadneedle Investments (US) | 750,161 | 283,500 | |
| 0.54231 % | Two Sigma Investments, LP | 684,881 | 230,177 | |
| 0.53611 % | RBC Wealth Management, International | 677,057 | -875 | |
| 0.47099 % | Bank of Nova Scotia | 594,812 | 594,812 | |
| 0.45784 % | Jefferies LLC | 578,205 | -21,050 | |
| 0.44237 % | Jump Financial, LLC | 558,668 | 293,075 | |
| 0.44022 % | Ossiam | 555,953 | 555,953 | |
| 0.43123 % | Capitolis Liquid Global Markets LLC | 544,600 | 544,600 | |
| 0.42040 % | Woodline Partners LP | 530,923 | 312,073 | |
| 0.38452 % | Schroder Investment Management Ltd. (SIM) | 485,615 | 232,506 | |
| 0.37612 % | Hudson Bay Capital Management LP | 475,000 | 164,300 | |
| 0.37281 % | Northern Trust Investments, Inc. | 470,823 | -381 | |
| 0.37114 % | Voloridge Investment Management, LLC | 468,710 | 214,920 | |
| 0.35394 % | Nuveen LLC | 446,997 | -36,461 | |
| 0.35043 % | Citadel Advisors LLC | 442,560 | 218,464 | |
| 0.32465 % | 683 Capital Management LLC | 410,000 | 77,000 | |
| 0.27583 % | Pictet Asset Management Ltd. | 348,349 | 33,507 | |
| 0.27470 % | IEQ Capital LLC | 346,923 | 55,065 | |
| 0.26669 % | CPP Investment Board | 336,800 | -711,900 | |
| 0.26082 % | Squarepoint Capital LLP | 329,392 | -113,401 | |
| 0.26029 % | Susquehanna International Group, LLP | 328,726 | 299,221 | |
| 0.25926 % | Trexquant Investment LP | 327,421 | -57,501 | |
| 0.25450 % | BlackRock Financial Management, Inc. | 321,406 | -109,155 | |
| 0.24412 % | ING Bank N.V. | 308,300 | 124,100 | |
| 0.21450 % | Pictet Asset Management (Japan) Ltd. | 270,886 | 97,935 | |
| 0.21396 % | Barclays Bank PLC | 270,213 | 79,859 | |
| 0.19880 % | D. E. Shaw & Co., L.P. | 251,069 | 251,069 | |
| 0.19495 % | Jane Street Capital, L.L.C. | 246,199 | -9,893 | |
| 0.19441 % | Dunlop (Andrew Sinclair) | 245,520 | -98,733 | |
| 0.18282 % | Caption Management, LLC | 230,888 | 218,888 | |
| 0.17293 % | Edgestream Partners, L.P. | 218,392 | -22,895 | |
| 0.16037 % | Fiduciary Trust Company | 202,536 | -800 | |
| 0.16031 % | Millennium Management LLC | 202,452 | -249,521 | |
| 0.15695 % | J.P. Morgan Securities LLC | 198,210 | -170,823 | |
| 0.14447 % | BlackRock Asset Management Ireland Limited | 182,456 | 22,865 | |
| 0.13992 % | Aquatic Capital Management LLC | 176,704 | -39,172 | |
| 0.13421 % | Aperio Group, LLC | 169,492 | 103,815 | |
| 0.13008 % | Y-Intercept (Hong Kong) Ltd | 164,275 | 134,698 | |
| 0.12674 % | PDT Partners, LLC | 160,058 | -35,107 | |
| 0.12572 % | Goldman Sachs & Company, Inc. | 158,773 | -106,884 | |
| 0.12511 % | BMO Capital Markets (US) | 158,000 | 0 | |
| 0.12203 % | Algert Global LLC | 154,113 | -184,500 | |
| 0.11924 % | Voya Investment Management LLC | 150,593 | 25,192 | |
| 0.11703 % | PGIM Securities Investment Trust Enterprise | 147,800 | -66,000 | |
| 0.11391 % | Rafferty Asset Management LLC | 143,852 | -36,282 | |
| 0.11386 % | Schweizerische Nationalbank | 143,800 | 11,200 | |
| 0.11369 % | UBS Asset Management (Switzerland) | 143,573 | 57,755 | |
| 0.11163 % | Steward Partners Investment Advisory, LLC | 140,975 | 18,800 | |
| 0.10963 % | Citi Investment Research (US) | 138,451 | -278,168 | |
| 0.10791 % | BlackRock Investment Management (UK) Ltd. | 136,276 | 13,131 | |
| 0.10661 % | California Public Employees' Retirement System | 134,637 | 7,931 | |
| 0.10102 % | Carson Wealth Management Group | 127,584 | 29,326 | |
| 0.09998 % | Managed Account Advisors LLC | 126,261 | 5,001 | |
| 0.09705 % | DWS Investments UK Limited | 122,566 | -2,834 | |
| 0.09660 % | Rhumbline Advisers Ltd. Partnership | 122,002 | -2,452 | |
| 0.09441 % | Gotham Asset Management, LLC | 119,229 | 84,944 | |
| 0.09401 % | Connor, Clark & Lunn Investment Management Ltd. | 118,724 | -13,171 | |
| 0.09329 % | RBC Dominion Securities, Inc. | 117,810 | 7,974 | |
| 0.09327 % | BNY Mellon Asset Management | 117,787 | -32,656 | |
| 0.09309 % | Mellon Investments Corporation | 117,569 | -46,512 | |
| 0.09300 % | Parametric Portfolio Associates LLC | 117,451 | 76,341 | |
| 0.09160 % | Bank J. Safra Sarasin AG (Asset Management) | 115,684 | 53,102 | |
| 0.09160 % | J. Safra Sarasin Holding AG | 115,684 | 68,588 | |
| 0.09086 % | Cerity Partners LLC | 114,745 | 60,301 | |
| 0.09060 % | BlackRock Investment Management, LLC | 114,423 | -1,864 | |
| 0.09054 % | Sphera Funds Management Ltd. | 114,346 | -67,000 | |
| 0.08914 % | Watson (David Osborne) | 112,580 | -5,000 | |
| 0.08786 % | Sullivan (Timothy Eugene) | 110,959 | -6,463 | |