| 16.87705 % | RA Capital Management, LP | 10,281,496 | 0 | |
| 8.94846 % | Westfield Capital Management Company, L.P. | 5,451,401 | -27,858 | |
| 8.17466 % | Avoro Capital Advisors LLC | 4,980,000 | -238,000 | |
| 7.26821 % | Janus Henderson Investors | 4,427,792 | -59,157 | |
| 6.86000 % | Fidelity Management & Research Company LLC | 4,179,114 | -125,413 | |
| 6.55027 % | Artisan Partners Limited Partnership | 3,990,424 | -266,203 | |
| 5.88238 % | T. Rowe Price Investment Management, Inc. | 3,583,546 | 529,722 | |
| 5.00153 % | Capital International Investors | 3,046,931 | 172,139 | |
| 3.11460 % | MFS Investment Management | 1,897,414 | 23,616 | |
| 3.07861 % | T. Rowe Price Associates, Inc. | 1,875,491 | -380,611 | |
| 2.25147 % | Capital World Investors | 1,371,594 | 16,613 | |
| 2.05279 % | Franklin Advisers, Inc. | 1,250,562 | 177,646 | |
| 1.58222 % | Perceptive Advisors LLC | 963,886 | 963,886 | |
| 1.50705 % | Wellington Management Company, LLP | 918,095 | 330,332 | |
| 1.48453 % | Invesco Advisers, Inc. | 904,374 | -246,458 | |
| 1.37521 % | Polar Capital LLP | 837,777 | 312,777 | |
| 0.96531 % | Columbia Threadneedle Investments (US) | 588,069 | -91,874 | |
| 0.96412 % | Citadel Advisors LLC | 587,342 | -537,841 | |
| 0.87132 % | American Century Investment Management, Inc. | 530,809 | 68,638 | |
| 0.84003 % | Medical Strategy GmbH | 511,748 | 38,500 | |
| 0.81710 % | Putnam Investment Management, L.L.C. | 497,779 | -63,999 | |
| 0.79373 % | Goldman Sachs & Company, Inc. | 483,539 | -53,509 | |
| 0.76181 % | Fidelity International | 464,096 | 1,730 | |
| 0.75444 % | Adage Capital Management, L.P. | 459,606 | 132,201 | |
| 0.71939 % | Mikkelsen Jan Moller | 438,250 | 14,971 | |
| 0.62000 % | AllianceBernstein L.P. | 377,701 | -54,397 | |
| 0.57881 % | Fidelity Institutional Asset Management | 352,610 | -15,806 | |
| 0.50140 % | Woodline Partners LP | 305,454 | 648 | |
| 0.47946 % | TD Asset Management Inc. | 292,090 | -51,300 | |
| 0.45467 % | BNP Paribas Asset Management USA, Inc. | 276,984 | -53,169 | |
| 0.43215 % | Voloridge Investment Management, LLC | 263,267 | -82,751 | |
| 0.41858 % | Q Global Advisors, LLC | 255,000 | 6,113 | |
| 0.41094 % | The Vanguard Group, Inc. | 250,342 | 0 | |
| 0.41037 % | Camber Capital Management LP | 250,000 | -100,000 | |
| 0.40371 % | Invus Public Equities Advisors, LLC | 245,943 | -41,423 | |
| 0.39953 % | BlackRock Institutional Trust Company, N.A. | 243,396 | -28,469 | |
| 0.38833 % | SEI Investments Management Corporation | 236,570 | -21,443 | |
| 0.36401 % | PFM Health Sciences, LP | 221,754 | 34,838 | |
| 0.35968 % | Victory Capital Management Inc. | 219,118 | 94,192 | |
| 0.35620 % | Rock Springs Capital Management LP | 217,000 | 1,000 | |
| 0.35286 % | Candriam Luxembourg S.A. | 214,963 | 0 | |
| 0.34460 % | ARS Investment Partners LLC | 209,930 | -55,550 | |
| 0.33001 % | Qube Research & Technologies Ltd | 201,044 | 91,412 | |
| 0.32872 % | Allspring Global Investments, LLC | 200,257 | 10,644 | |
| 0.32830 % | Vestal Point Capital, LP | 200,000 | 49,858 | |
| 0.32028 % | Candriam Belgium S.A. | 195,115 | -47,646 | |
| 0.32027 % | Driehaus Capital Management, LLC | 195,108 | 43,279 | |
| 0.30922 % | Morgan Stanley & Co. LLC | 188,379 | -1,676,305 | |
| 0.29967 % | New York State Common Retirement Fund | 182,558 | -21,924 | |
| 0.29535 % | Catalio Capital Management, LP | 179,926 | -15,597 | |
| 0.27194 % | BNP Paribas Securities Corp. North America | 165,667 | 23,043 | |
| 0.26873 % | BlackRock Financial Management, Inc. | 163,711 | -18,147 | |
| 0.26374 % | Resolute Capital Asset Partners LLC | 160,672 | -6,828 | |
| 0.26282 % | Rice Hall James & Associates, LLC | 160,110 | -686 | |
| 0.26101 % | JPMorgan Asset Management U.K. Limited | 159,007 | 3,053 | |
| 0.26101 % | JPMorgan Asset Management (Europe) S.à.r.l. | 159,007 | -1,152 | |
| 0.25308 % | Lord, Abbett & Co. LLC | 154,176 | 94,781 | |
| 0.24509 % | Pictet Asset Management (Japan) Ltd. | 149,310 | 18,559 | |
| 0.24376 % | Loomis, Sayles & Company, L.P. | 148,497 | -26,416 | |
| 0.24235 % | Tri Locum Partners LP | 147,642 | 115,317 | |
| 0.22916 % | abrdn Inc. | 139,606 | -32,125 | |
| 0.22109 % | First Turn Management, LLC | 134,687 | 21,409 | |
| 0.21887 % | Frazier Life Sciences Management, L.P. | 133,333 | 0 | |
| 0.21339 % | Summit Partners Public Asset Management, LLC | 130,000 | 130,000 | |
| 0.19698 % | Moore Capital Management, LP | 120,000 | 30,000 | |
| 0.19232 % | Marshall Wace LLP | 117,162 | 94,868 | |
| 0.19162 % | Macquarie Investment Management | 116,735 | 47,712 | |
| 0.16565 % | Readystate Asset Management LP | 100,917 | 100,917 | |
| 0.14207 % | SilverArc Capital Management, LLC | 86,552 | 10,801 | |
| 0.14041 % | Pictet Asset Management Ltd. | 85,538 | -21,220 | |
| 0.13953 % | Soleus Capital Management, L.P. | 85,000 | 28,700 | |
| 0.13585 % | UBS Financial Services, Inc. | 82,760 | -91,081 | |
| 0.13349 % | BofA Global Research (US) | 81,325 | -43,503 | |
| 0.13341 % | Norges Bank Investment Management (NBIM) | 81,276 | -82,014 | |
| 0.12896 % | Harbor Capital Advisors, Inc. | 78,560 | -7,400 | |
| 0.11965 % | Millennium Management LLC | 72,888 | -191,979 | |
| 0.11930 % | Dafna Capital Management, LLC | 72,677 | -7,721 | |
| 0.11540 % | Mellon Investments Corporation | 70,303 | 16,855 | |
| 0.10528 % | Trexquant Investment LP | 64,135 | 20,375 | |
| 0.10431 % | Oddo BHF Asset Management S.A.S | 63,547 | 63,547 | |
| 0.10132 % | Ensign Peak Advisors, Inc. | 61,724 | 0 | |
| 0.09981 % | Geode Capital Management, L.L.C. | 60,804 | 2,953 | |
| 0.09562 % | Manulife Investment Management (North America) Limited | 58,251 | -20,881 | |
| 0.09554 % | State Street Global Advisors (US) | 58,203 | -8,576 | |
| 0.09369 % | AEGON Investment Management B.V. | 57,076 | 2,920 | |
| 0.09355 % | Schroder Investment Management Ltd. (SIM) | 56,989 | -47,928 | |
| 0.08948 % | Sterling Capital Management, LLC | 54,509 | 3,432 | |
| 0.08767 % | Goldman Sachs Asset Management, L.P. | 53,407 | 4,874 | |
| 0.08639 % | Lazard Asset Management, L.L.C. | 52,628 | 9,505 | |
| 0.07455 % | Diversified Trust Company | 45,418 | -1,130 | |
| 0.07417 % | J.P. Morgan Securities LLC | 45,182 | 20,984 | |
| 0.06912 % | Parkman Healthcare Partners LLC | 42,108 | 42,108 | |
| 0.06632 % | Walleye Capital LLC | 40,403 | 24,566 | |
| 0.06615 % | Zimmer Partners, LP | 40,300 | 4,200 | |
| 0.06599 % | International Asset Management Limited | 40,200 | -15,197 | |
| 0.06269 % | Saturn V Capital Management LP | 38,191 | -161,073 | |
| 0.05914 % | BlackRock Advisors (UK) Limited | 36,031 | 5,754 | |
| 0.05900 % | Thrivent Asset Management, LLC | 35,941 | -42,532 | |
| 0.05691 % | Macquarie Investment Management Global Ltd. | 34,672 | 0 | |
| 0.05647 % | OrbiMed Advisors, LLC | 34,400 | 34,400 | |