| 11.19581 % | ARK Investment Management LLC | 10,182,590 | 17,190 | |
| 6.15035 % | Capital International Investors | 5,593,747 | -479,371 | |
| 5.95821 % | BlackRock Institutional Trust Company, N.A. | 5,418,993 | 3,004,147 | |
| 4.04951 % | T. Rowe Price Investment Management, Inc. | 3,683,026 | -115,077 | |
| 3.59604 % | State Street Global Advisors (US) | 3,270,596 | 859,334 | |
| 3.17830 % | Two Sigma Investments, LP | 2,890,666 | 904,307 | |
| 3.03962 % | Orbis Investment Management Ltd. | 2,764,532 | 1,201,600 | |
| 2.84501 % | UBS Financial Services, Inc. | 2,587,541 | 859,429 | |
| 2.65513 % | Nikko Asset Management Co., Ltd. | 2,414,838 | -125,051 | |
| 2.65450 % | Nikko Asset Management Americas, Inc. | 2,414,271 | -125,618 | |
| 2.50581 % | The Vanguard Group, Inc. | 2,279,038 | 528,380 | |
| 2.27805 % | Geode Capital Management, L.L.C. | 2,071,883 | 1,025,979 | |
| 2.12111 % | Fidelity Management & Research Company LLC | 1,929,154 | -11,391 | |
| 1.74585 % | New Enterprise Associates (NEA) | 1,587,854 | 0 | |
| 1.52752 % | EcoR1 Capital, LLC | 1,389,276 | 0 | |
| 1.48472 % | BofA Global Research (US) | 1,350,349 | 55,367 | |
| 1.15333 % | George (Simeon J.) | 1,048,951 | 0 | |
| 1.15333 % | SR One Capital Management, LP | 1,048,951 | 0 | |
| 1.02606 % | Charles Schwab Investment Management, Inc. | 933,204 | 219,665 | |
| 1.00903 % | Dimensional Fund Advisors, L.P. | 917,712 | -19,433 | |
| 0.94215 % | Loomis, Sayles & Company, L.P. | 856,887 | -52,905 | |
| 0.84656 % | Susquehanna International Group, LLP | 769,945 | 478,929 | |
| 0.80880 % | National Bank of Canada | 735,600 | 735,600 | |
| 0.76492 % | Northern Trust Investments, Inc. | 695,691 | 504,099 | |
| 0.54817 % | Versant Ventures | 498,558 | 0 | |
| 0.53634 % | BMO Capital Markets (US) | 487,800 | 487,800 | |
| 0.53323 % | Vestmark Advisory Solutions, Inc | 484,975 | 259,669 | |
| 0.49672 % | UBS Asset Management (Switzerland) | 451,770 | -663,966 | |
| 0.46234 % | UBS Asset Management (Americas) LLC | 420,500 | -330,776 | |
| 0.44693 % | Norges Bank Investment Management (NBIM) | 406,487 | -37,049 | |
| 0.41664 % | Barclays Bank PLC | 378,937 | 290,190 | |
| 0.41226 % | Contrarius Investment Management Ltd. | 374,954 | 42,982 | |
| 0.39176 % | Jump Financial, LLC | 356,306 | 356,306 | |
| 0.30864 % | Kulkarni (Samarth) | 280,707 | 44,217 | |
| 0.28817 % | Columbia Threadneedle Investments (US) | 262,089 | 44,029 | |
| 0.28252 % | BlackRock Financial Management, Inc. | 256,955 | 228,760 | |
| 0.28151 % | UBS Switzerland AG | 256,036 | -87,744 | |
| 0.26108 % | Morgan Stanley Smith Barney LLC | 237,453 | -1,728 | |
| 0.25940 % | Pictet Asset Management Ltd. | 235,920 | -10,166 | |
| 0.25114 % | TD Asset Management Inc. | 228,416 | -13,904 | |
| 0.24805 % | Pictet Asset Management (Japan) Ltd. | 225,600 | 76,566 | |
| 0.24654 % | RBC Dominion Securities, Inc. | 224,230 | 190,768 | |
| 0.23200 % | BlackRock Investment Management, LLC | 211,006 | 211,006 | |
| 0.22962 % | JPMorgan Asset Management U.K. Limited | 208,836 | -11,485 | |
| 0.22019 % | Morgan Stanley & Co. LLC | 200,259 | -824,653 | |
| 0.21507 % | IQ EQ Fund Management (Ireland) Limited | 195,602 | 130,407 | |
| 0.21394 % | LPL Financial LLC | 194,579 | 9,121 | |
| 0.19851 % | Wells Fargo Advisors | 180,541 | -84,735 | |
| 0.19394 % | Nuveen LLC | 176,387 | 176,387 | |
| 0.17196 % | Schweizerische Nationalbank | 156,400 | -700 | |
| 0.16755 % | Goldman Sachs & Company, Inc. | 152,383 | 21,258 | |
| 0.16572 % | BNY Mellon Asset Management | 150,720 | 131,272 | |
| 0.16412 % | Woodline Partners LP | 149,267 | 12,784 | |
| 0.15997 % | Mellon Investments Corporation | 145,497 | 92,808 | |
| 0.14773 % | BlackRock Advisors (UK) Limited | 134,357 | 8,954 | |
| 0.14246 % | Legal & General Investment Management Ltd. | 129,567 | 48,412 | |
| 0.14127 % | T. Rowe Price Associates, Inc. | 128,482 | -1,858 | |
| 0.14019 % | Nordea Funds Oy | 127,500 | 900 | |
| 0.13952 % | Citi Investment Research (US) | 126,892 | -78,756 | |
| 0.13622 % | Rhumbline Advisers Ltd. Partnership | 123,893 | 123,893 | |
| 0.12683 % | Rockefeller Capital Management | 115,356 | 24,853 | |
| 0.12573 % | Rafferty Asset Management LLC | 114,348 | -31,684 | |
| 0.12309 % | Private Advisor Group LLC | 111,949 | 3,531 | |
| 0.12175 % | BlackRock Asset Management Ireland Limited | 110,730 | 8,057 | |
| 0.11955 % | Mirae Asset Global Investments (USA) LLC | 108,734 | 30,584 | |
| 0.11394 % | California Public Employees' Retirement System | 103,628 | 8,011 | |
| 0.11190 % | Reynders, McVeigh Capital Management, LLC | 101,773 | 4,086 | |
| 0.11172 % | RBC Capital Markets Wealth Management | 101,605 | -2,387 | |
| 0.10995 % | Integral Health Asset Management, LLC | 100,000 | -50,000 | |
| 0.10782 % | Managed Account Advisors LLC | 98,066 | 6,278 | |
| 0.10248 % | Marshall & Melhorn LLC | 93,205 | 0 | |
| 0.10219 % | EverSource Wealth Advisors, LLC | 92,943 | 8,063 | |
| 0.10062 % | Capital International Sarl | 91,517 | -11,425 | |
| 0.09524 % | AllianceBernstein L.P. | 86,620 | 86,620 | |
| 0.09153 % | Dimensional Fund Advisors, Ltd. | 83,246 | 0 | |
| 0.09139 % | Himension Capital (Singapore) Pte. Ltd | 83,120 | -10,454 | |
| 0.09127 % | Van Eck Associates Corporation | 83,010 | 0 | |
| 0.09083 % | Wealth Enhancement Advisory Services, LLC | 82,607 | -11,493 | |
| 0.09034 % | Medical Strategy GmbH | 82,162 | 9,800 | |
| 0.08986 % | Kasinger (James R.) | 81,729 | 7,248 | |
| 0.08664 % | SELECTRA Management Company S.A. | 78,800 | -8,600 | |
| 0.08356 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 76,000 | 0 | |
| 0.08290 % | Slow Capital, Inc. | 75,396 | 10,152 | |
| 0.08236 % | California State Teachers Retirement System | 74,907 | 5,165 | |
| 0.07707 % | Millennium Management LLC | 70,093 | -513,640 | |
| 0.07521 % | Congress Asset Management Company, LLP | 68,404 | 102 | |
| 0.07500 % | Goldman Sachs Asset Management, L.P. | 68,217 | 52,014 | |
| 0.07470 % | Envestnet Asset Management, Inc. | 67,942 | -116 | |
| 0.07297 % | T. Rowe Price International Ltd | 66,367 | 39,004 | |
| 0.07149 % | UBS Fund Management (Switzerland) AG | 65,021 | -646 | |
| 0.07020 % | Del-Sette Capital Management, LLC | 63,843 | 63,843 | |
| 0.06880 % | Commonwealth Financial Network | 62,574 | -12,308 | |
| 0.06768 % | Capital International Ltd. | 61,552 | -10,511 | |
| 0.06719 % | Raymond James Financial Services Advisors, Inc. | 61,105 | 4,538 | |
| 0.06524 % | Lazard Asset Management, L.L.C. | 59,333 | -4,357 | |
| 0.06431 % | Guggenheim Investments | 58,488 | -37,778 | |
| 0.06428 % | Green Alpha Investments | 58,463 | 1,102 | |
| 0.06351 % | Benjamin Edwards, Inc | 57,760 | 6,845 | |
| 0.06322 % | Saint Olive Gestion | 57,500 | 0 | |
| 0.06296 % | DWS Investments UK Limited | 57,260 | 51,860 | |