| 13.96920 % | Opaleye Management Inc. | 12,610,000 | 10,000 |  | 
| 7.97607 % | Casdin Capital, LLC | 7,200,000 | -900,000 |  | 
| 6.48395 % | BlackRock Institutional Trust Company, N.A. | 5,853,063 | -376,848 |  | 
| 5.08387 % | The Vanguard Group, Inc. | 4,589,213 | -135,728 |  | 
| 4.81935 % | Fidelity Management & Research Company LLC | 4,350,423 | 40,932 |  | 
| 4.65376 % | abrdn Inc. | 4,200,950 | 3,594,656 |  | 
| 4.46507 % | Nantahala Capital Management, LLC | 4,030,619 | 1,200,000 |  | 
| 4.43115 % | Telemark Asset Management, LLC | 4,000,000 | 1,000,000 |  | 
| 2.82575 % | Columbia Threadneedle Investments (US) | 2,550,806 | 16,099 |  | 
| 2.19106 % | Geode Capital Management, L.L.C. | 1,977,869 | 52,588 |  | 
| 2.12159 % | Pier Capital, LLC | 1,915,160 | 245,956 |  | 
| 1.86736 % | Baillie Gifford & Co. | 1,685,664 | -13,980 |  | 
| 1.78724 % | State Street Global Advisors (US) | 1,613,338 | -33,899 |  | 
| 1.30512 % | Jacobs Levy Equity Management, Inc. | 1,178,131 | 107,878 |  | 
| 1.06776 % | BlackRock Financial Management, Inc. | 963,864 | -85,101 |  | 
| 0.96281 % | Federated MDTA LLC | 869,130 | -211,663 |  | 
| 0.83692 % | Renaissance Technologies LLC | 755,486 | 104,700 |  | 
| 0.77611 % | Prescott Group Capital Management, LLC | 700,591 | 131,617 |  | 
| 0.71525 % | Northern Trust Investments, Inc. | 645,658 | -3,558 |  | 
| 0.66160 % | Dilly (Stephen George) | 597,224 | 50,367 |  | 
| 0.63381 % | Dimensional Fund Advisors, L.P. | 572,139 | 113,523 |  | 
| 0.57928 % | Private Advisor Group LLC | 522,913 | 180,253 |  | 
| 0.52656 % | Baillie Gifford Overseas Ltd. | 475,328 | 0 |  | 
| 0.51767 % | Post Resch Tallon Group, Inc. | 467,301 | -1,286 |  | 
| 0.49516 % | Putnam Investment Management, L.L.C. | 446,978 | 178,333 |  | 
| 0.44718 % | Tallon Kerry Patrick | 403,667 | 403,667 |  | 
| 0.44312 % | ACATIS Investment Kapitalverwaltungsgesellschaft GmbH | 400,000 | 0 |  | 
| 0.41254 % | Morgan Stanley & Co. LLC | 372,402 | 38,016 |  | 
| 0.35639 % | Mink Brook Asset Management LLC | 321,711 | 195,069 |  | 
| 0.35049 % | Platinum Asset Management | 316,383 | 0 |  | 
| 0.34563 % | Perkins Capital Management, Inc. | 312,000 | -6,800 |  | 
| 0.32680 % | Empire Financial Management Company, LLC | 295,000 | 0 |  | 
| 0.32344 % | Nuveen LLC | 291,969 | -944,586 |  | 
| 0.32197 % | Goldman Sachs & Company, Inc. | 290,644 | 145,836 |  | 
| 0.29682 % | BlackRock Investment Management, LLC | 267,935 | 18,009 |  | 
| 0.28795 % | Fidelity Institutional Asset Management | 259,934 | 0 |  | 
| 0.28050 % | Barclays Bank PLC | 253,207 | 55,073 |  | 
| 0.27775 % | Charles Schwab Investment Management, Inc. | 250,726 | 476 |  | 
| 0.26378 % | RBC Capital Markets Wealth Management | 238,110 | -136,804 |  | 
| 0.25446 % | Assenagon Asset Management S.A. | 229,697 | -372,591 |  | 
| 0.21522 % | Smith (David V) | 194,275 | 40,983 |  | 
| 0.21431 % | Dorgan (Byron L) | 193,461 | -30,120 |  | 
| 0.20014 % | LPL Financial LLC | 180,665 | -39,460 |  | 
| 0.19292 % | UBS Financial Services, Inc. | 174,150 | -117,834 |  | 
| 0.18047 % | Inspire Investing | 162,912 | 36,809 |  | 
| 0.17754 % | Norrett (Kevin) | 160,269 | 15,527 |  | 
| 0.17517 % | Goldman Sachs Asset Management, L.P. | 158,126 | -6,152 |  | 
| 0.16385 % | Wolf (Dennis P) | 147,903 | 40,983 |  | 
| 0.15906 % | Parker (H Stewart) | 143,583 | 40,983 |  | 
| 0.15260 % | White Pine Capital, L.L.C. | 137,749 | -57,332 |  | 
| 0.15017 % | Rhumbline Advisers Ltd. Partnership | 135,556 | 27,897 |  | 
| 0.14629 % | Singhvi (Rahul) | 132,052 | 40,983 |  | 
| 0.14500 % | BNY Mellon Asset Management | 130,896 | -3,291 |  | 
| 0.14294 % | Martinborough (Esther) | 129,036 | 40,983 |  | 
| 0.13086 % | AllianceBernstein L.P. | 118,130 | 315 |  | 
| 0.13079 % | RBC Dominion Securities, Inc. | 118,061 | 118,061 |  | 
| 0.12961 % | Millennium Management LLC | 117,002 | 117,002 |  | 
| 0.12773 % | State Teachers Retirement System of Ohio | 115,300 | 8,200 |  | 
| 0.12425 % | Collins (Cynthia) | 112,157 | 40,983 |  | 
| 0.12390 % | Citadel Advisors LLC | 111,848 | -105,825 |  | 
| 0.11677 % | Ryali (Sriram) | 105,406 | 40,965 |  | 
| 0.11341 % | Marshall Wace LLP | 102,378 | 102,378 |  | 
| 0.11326 % | Susquehanna International Group, LLP | 102,239 | -2,064 |  | 
| 0.11178 % | Bridgeway Capital Management, LLC | 100,908 | 6,300 |  | 
| 0.10933 % | Moore (Alison) | 98,696 | -76,875 |  | 
| 0.10716 % | Parametric Portfolio Associates LLC | 96,731 | -12,783 |  | 
| 0.09840 % | De Vre (Raymond) | 88,829 | 40,983 |  | 
| 0.09431 % | Richards (Christos) | 85,133 | 40,983 |  | 
| 0.09367 % | AQR Capital Management, LLC | 84,556 | 6,524 |  | 
| 0.09341 % | Fitzgerald (Margaret Nell) | 84,324 | -2,810 |  | 
| 0.09088 % | Acadian Asset Management LLC | 82,037 | -313,197 |  | 
| 0.08823 % | Two Sigma Investments, LP | 79,648 | -62,781 |  | 
| 0.08516 % | Erbez (Georgia L) | 76,875 | 26,875 |  | 
| 0.08497 % | Mellon Investments Corporation | 76,699 | -13,504 |  | 
| 0.08187 % | Invesco Capital Management LLC | 73,907 | 26,801 |  | 
| 0.07986 % | Conestoga Capital Advisors, LLC | 72,093 | -12,600 |  | 
| 0.07644 % | Clough Capital Partners, LP | 69,000 | 0 |  | 
| 0.07577 % | Envestnet Asset Management, Inc. | 68,402 | -312,548 |  | 
| 0.07312 % | UBS Asset Management (Americas) LLC | 66,004 | 0 |  | 
| 0.07231 % | Dimensional Fund Advisors, Ltd. | 65,270 | 0 |  | 
| 0.06426 % | RBC Wealth Management, International | 58,006 | -4,206 |  | 
| 0.05944 % | BlackRock Advisors (UK) Limited | 53,661 | 8,419 |  | 
| 0.05910 % | BofA Global Research (US) | 53,346 | -8,215 |  | 
| 0.05578 % | MetLife Investment Management, LLC | 50,349 | 30,533 |  | 
| 0.05539 % | Paradigm Capital Management, Inc. | 50,000 | 0 |  | 
| 0.05407 % | Mirae Asset Global Investments (USA) LLC | 48,806 | -1,600 |  | 
| 0.05361 % | INTECH Investment Management LLC | 48,395 | -16,090 |  | 
| 0.05261 % | XTX Markets LLC | 47,492 | 47,492 |  | 
| 0.05175 % | Ohio Public Employees Retirement System | 46,713 | 0 |  | 
| 0.05012 % | BlackRock Asset Management Ireland Limited | 45,242 | 7,567 |  | 
| 0.04896 % | Wells Fargo Bank, N.A. | 44,193 | -3,062 |  | 
| 0.04743 % | Commonwealth Financial Network | 42,811 | -6,698 |  | 
| 0.04656 % | Brevan Howard Capital Management LP | 42,029 | -8,808 |  | 
| 0.04486 % | T. Rowe Price International Ltd | 40,497 | 6,298 |  | 
| 0.04430 % | Stifel, Nicolaus & Company, Incorporated | 39,991 | -2,130 |  | 
| 0.04372 % | Corebridge Financial Inc. | 39,468 | -584 |  | 
| 0.04286 % | JPMorgan Private Bank (United States) | 38,691 | 593 |  | 
| 0.04080 % | William Blair & Company, L.L.C. (Research) | 36,830 | 0 |  | 
| 0.03701 % | Vaughan Nelson Investment Management, L.P. | 33,409 | 0 |  | 
| 0.03463 % | Citi Investment Research (US) | 31,265 | -26,284 |  |