| 12.12657 %  | ARK Investment Management LLC | 13,017,876 | 6,861 |  | 
| 10.08941 %  | The Vanguard Group, Inc. | 10,830,980 | 100,138 |  | 
| 7.48917 %  | BlackRock Institutional Trust Company, N.A. | 8,039,627 | -367,465 |  | 
| 4.07042 %  | Two Sigma Investments, LP | 4,369,591 | 394,369 |  | 
| 3.76272 %  | State Street Investment Management (US) | 4,039,285 | -470,976 |  | 
| 3.44946 %  | Regeneron Pharmaceuticals Inc | 3,702,995 | 0 |  | 
| 2.49248 %  | Baker Bros. Advisors LP | 2,675,674 | 2,031,558 |  | 
| 2.42778 %  | Geode Capital Management, L.L.C. | 2,606,222 | 126,049 |  | 
| 2.19362 %  | Amova Asset Management Co., Ltd. | 2,354,856 | -316,409 |  | 
| 1.82123 %  | Morgan Stanley Investment Management Inc. (US) | 1,955,087 | 783,720 |  | 
| 1.73853 %  | Dimensional Fund Advisors, L.P. | 1,866,309 | -101,857 |  | 
| 1.53082 %  | Goldman Sachs & Company, Inc. | 1,643,331 | -615,092 |  | 
| 1.44689 %  | Voloridge Investment Management, LLC | 1,553,234 | 37,620 |  | 
| 1.44621 %  | Contrarius Investment Management Ltd. | 1,552,508 | -468,532 |  | 
| 1.41644 %  | Fidelity Management & Research Company LLC | 1,520,548 | -69,754 |  | 
| 1.22169 %  | Balyasny Asset Management LP | 1,311,480 | -203,605 |  | 
| 1.18284 %  | Morgan Stanley & Co. LLC | 1,269,783 | -790,777 |  | 
| 1.13560 %  | Woodline Partners LP | 1,219,068 | 1,194,962 |  | 
| 1.06366 %  | BlackRock Financial Management, Inc. | 1,141,842 | -65,686 |  | 
| 1.05015 %  | Trexquant Investment LP | 1,127,331 | 522,635 |  | 
| 0.85107 %  | Granahan Investment Management, LLC | 913,622 | 437,676 |  | 
| 0.83229 %  | Leonard (John M) | 893,460 | 81,871 |  | 
| 0.79790 %  | Charles Schwab Investment Management, Inc. | 856,549 | 76,325 |  | 
| 0.77411 %  | Millennium Management LLC | 831,006 | 244,517 |  | 
| 0.76826 %  | D. E. Shaw & Co., L.P. | 824,727 | 792,331 |  | 
| 0.75086 %  | Northern Trust Investments, Inc. | 806,045 | -12,505 |  | 
| 0.73107 %  | Stifel, Nicolaus & Company, Incorporated | 784,808 | -4,645 |  | 
| 0.71167 %  | Susquehanna International Group, LLP | 763,981 | 334,876 |  | 
| 0.67948 %  | Himension Capital (Singapore) Pte. Ltd | 729,421 | -23,255 |  | 
| 0.66137 %  | Citadel Advisors LLC | 709,981 | -2,047,587 |  | 
| 0.63055 %  | Renaissance Technologies LLC | 676,900 | 676,900 |  | 
| 0.60550 %  | Armistice Capital LLC | 650,000 | 286,000 |  | 
| 0.59464 %  | Vestmark Advisory Solutions, Inc | 638,342 | 326,460 |  | 
| 0.58090 %  | Marex Group plc | 623,600 | 623,600 |  | 
| 0.55142 %  | UBS Financial Services, Inc. | 591,949 | -259,703 |  | 
| 0.49969 %  | Parametric Portfolio Associates LLC | 536,416 | 319,523 |  | 
| 0.47635 %  | Barclays Bank PLC | 511,362 | 273,635 |  | 
| 0.45101 %  | J.P. Morgan Securities LLC | 484,154 | 483,587 |  | 
| 0.43316 %  | Hudson Bay Capital Management LP | 465,000 | -100,000 |  | 
| 0.42534 %  | Jump Financial, LLC | 456,601 | -47,208 |  | 
| 0.42474 %  | UBS Asset Management (Switzerland) | 455,959 | 99,247 |  | 
| 0.39745 %  | BNP Paribas Securities Corp. North America | 426,667 | 86,210 |  | 
| 0.38182 %  | American Century Investment Management, Inc. | 409,884 | -61,792 |  | 
| 0.37860 %  | Schroder Investment Management Ltd. (SIM) | 406,425 | 382,425 |  | 
| 0.37626 %  | Goldman Sachs Asset Management, L.P. | 403,917 | 249,157 |  | 
| 0.37100 %  | BlackRock Investment Management, LLC | 398,266 | 28,077 |  | 
| 0.34616 %  | Capital Fund Management S.A. | 371,607 | 235,353 |  | 
| 0.29254 %  | Morgan Stanley Smith Barney LLC | 314,038 | -20,714 |  | 
| 0.28533 %  | BofA Global Research (US) | 306,306 | -517,067 |  | 
| 0.27946 %  | Wanjia Asset Management Co., Ltd. | 300,000 | 150,000 |  | 
| 0.27423 %  | IQ EQ Fund Management (Ireland) Limited | 294,387 | 188,178 |  | 
| 0.26914 %  | UBS Switzerland AG | 288,924 | 13,772 |  | 
| 0.23261 %  | Raymond James & Associates, Inc. | 249,711 | 49,592 |  | 
| 0.21934 %  | Amova Asset Management Americas, Inc | 235,466 | 235,466 |  | 
| 0.21869 %  | Graham Capital Management, L.P. | 234,764 | 234,764 |  | 
| 0.21612 %  | Avidity Partners Management LP | 232,000 | 232,000 |  | 
| 0.21304 %  | Discovery Value Fund | 228,701 | -332,860 |  | 
| 0.20617 %  | HRT Financial LP | 221,328 | 133,175 |  | 
| 0.20585 %  | Nuveen LLC | 220,982 | -34,856 |  | 
| 0.20413 %  | JPMorgan Asset Management U.K. Limited | 219,134 | -12,237 |  | 
| 0.19826 %  | Jane Street Capital, L.L.C. | 212,830 | 64,795 |  | 
| 0.19314 %  | Invesco Capital Management LLC | 207,335 | 78,173 |  | 
| 0.19266 %  | BlackRock Advisors (UK) Limited | 206,819 | 4,731 |  | 
| 0.18309 %  | PDT Partners, LLC | 196,550 | -263,696 |  | 
| 0.17457 %  | Schweizerische Nationalbank | 187,400 | 0 |  | 
| 0.17176 %  | GSA Capital Partners LLP | 184,383 | -35,535 |  | 
| 0.17132 %  | BNY Mellon Asset Management | 183,908 | 9,067 |  | 
| 0.16556 %  | Aperio Group, LLC | 177,726 | 47,054 |  | 
| 0.16044 %  | Wells Fargo Advisors | 172,235 | -124,414 |  | 
| 0.16035 %  | BlackRock Asset Management Ireland Limited | 172,132 | -59,357 |  | 
| 0.15776 %  | Pinnacle Associates Ltd. | 169,350 | -45,470 |  | 
| 0.15300 %  | Rhumbline Advisers Ltd. Partnership | 164,246 | 7,408 |  | 
| 0.15020 %  | Group One Trading, L.P. | 161,236 | 144,235 |  | 
| 0.14551 %  | Susquehanna Fundamental Investments, LLC | 156,204 | 0 |  | 
| 0.14423 %  | JP Morgan Asset Management | 154,827 | -66,802 |  | 
| 0.14295 %  | Voya Investment Management LLC | 153,456 | -113,605 |  | 
| 0.14010 %  | Hennion & Walsh Asset Management, Inc. | 150,393 | -2,757 |  | 
| 0.13880 %  | SELECTRA Management Company S.A. | 149,000 | 0 |  | 
| 0.13635 %  | Sydbank | 146,377 | -5,075 |  | 
| 0.13487 %  | Citi Investment Research (US) | 144,781 | -152,625 |  | 
| 0.13309 %  | DWS Investments UK Limited | 142,868 | -13,317 |  | 
| 0.12840 %  | Rockefeller Capital Management | 137,838 | 0 |  | 
| 0.12832 %  | TwinBeech Capital LP | 137,756 | 137,756 |  | 
| 0.12789 %  | Y-Intercept (Hong Kong) Ltd | 137,290 | 137,290 |  | 
| 0.12719 %  | AQR Capital Management, LLC | 136,540 | 45,665 |  | 
| 0.12437 %  | Mirae Asset Global Investments (USA) LLC | 133,507 | -87,578 |  | 
| 0.12391 %  | Engineers Gate Manager, L.P. | 133,014 | 8,450 |  | 
| 0.12210 %  | SG Americas Securities, L.L.C. | 131,070 | 92,485 |  | 
| 0.11997 %  | Rafferty Asset Management LLC | 128,793 | -51,299 |  | 
| 0.11996 %  | Sphera Funds Management Ltd. | 128,780 | -252,300 |  | 
| 0.11547 %  | Cathay Securities Investment Trust Co., Ltd. | 123,954 | -619 |  | 
| 0.11443 %  | Managed Account Advisors LLC | 122,842 | 632 |  | 
| 0.11299 %  | Geneva Capital Management LLC | 121,298 | 3,508 |  | 
| 0.11175 %  | Chase (William J) | 119,967 | 100,000 |  | 
| 0.10709 %  | Tudor Investment Corporation | 114,964 | 46,687 |  | 
| 0.10673 %  | Mellon Investments Corporation | 114,576 | 10,762 |  | 
| 0.10567 %  | Universal-Investment-Gesellschaft mbH | 113,438 | 48,438 |  | 
| 0.10117 %  | Verition Fund Management LLC | 108,605 | -162,829 |  | 
| 0.10010 %  | Legal & General Investment Management Ltd. | 107,459 | 3,591 |  | 
| 0.09894 %  | Oppenheimer Asset Management Inc. | 106,214 | 87,506 |  |