| 14.83342 % | Fidelity Management & Research Company LLC | 23,642,990 | 29,405 | |
| 10.46522 % | The Vanguard Group, Inc. | 16,680,508 | 329,288 | |
| 10.06884 % | T. Rowe Price Investment Management, Inc. | 16,048,721 | -126,812 | |
| 7.86761 % | Capital World Investors | 12,540,188 | 178,194 | |
| 5.47499 % | BlackRock Institutional Trust Company, N.A. | 8,726,586 | -171,636 | |
| 4.92703 % | Bellevue Asset Management AG | 7,853,198 | 0 | |
| 3.98129 % | Wellington Management Company, LLP | 6,345,776 | -2,070,645 | |
| 3.06892 % | Deep Track Capital LP | 4,891,544 | 327,337 | |
| 2.84234 % | State Street Global Advisors (US) | 4,530,398 | -314,735 | |
| 2.79564 % | Two Sigma Investments, LP | 4,455,978 | 678,114 | |
| 2.38409 % | Adage Capital Management, L.P. | 3,800,000 | 2,724,400 | |
| 1.87875 % | T. Rowe Price Associates, Inc. | 2,994,547 | -144,419 | |
| 1.81438 % | Tweedy, Browne Company LLC | 2,891,948 | -91,570 | |
| 1.81385 % | Geode Capital Management, L.L.C. | 2,891,095 | 48,141 | |
| 1.66229 % | Millennium Management LLC | 2,649,527 | 2,014,157 | |
| 1.20044 % | BVF Partners L.P. | 1,913,385 | 0 | |
| 0.93794 % | Citadel Advisors LLC | 1,494,981 | -1,985,081 | |
| 0.93345 % | Charles Schwab Investment Management, Inc. | 1,487,818 | 44,189 | |
| 0.89973 % | Macquarie Investment Management | 1,434,073 | -233,121 | |
| 0.84527 % | BNP Paribas Asset Management USA, Inc. | 1,347,280 | 150,888 | |
| 0.83739 % | UBS Financial Services, Inc. | 1,334,719 | -555,883 | |
| 0.73118 % | Macquarie Investment Management Global Ltd. | 1,165,423 | 0 | |
| 0.71630 % | BlackRock Financial Management, Inc. | 1,141,709 | -41,908 | |
| 0.69307 % | TD Asset Management Inc. | 1,104,690 | 4,224 | |
| 0.62739 % | Polar Capital LLP | 1,000,000 | 1,000,000 | |
| 0.56485 % | ARK Investment Management LLC | 900,318 | -100,209 | |
| 0.54754 % | Candriam Luxembourg S.A. | 872,727 | -42,606 | |
| 0.53619 % | Voloridge Investment Management, LLC | 854,634 | 477,430 | |
| 0.52866 % | BofA Global Research (US) | 842,637 | 194,418 | |
| 0.48224 % | Balyasny Asset Management LP | 768,648 | 768,648 | |
| 0.47054 % | Hudson Bay Capital Management LP | 750,000 | -299,900 | |
| 0.45976 % | Woodline Partners LP | 732,813 | 732,813 | |
| 0.45470 % | Candriam Belgium S.A. | 724,740 | -268,964 | |
| 0.43519 % | Northern Trust Investments, Inc. | 693,647 | -35,326 | |
| 0.41927 % | Teacher Retirement System of Texas | 668,273 | 167,822 | |
| 0.41468 % | Groupama Asset Management | 660,957 | 91,746 | |
| 0.39848 % | Pictet Asset Management (Japan) Ltd. | 635,141 | -140,268 | |
| 0.38971 % | Morgan Stanley & Co. LLC | 621,159 | 147,635 | |
| 0.38641 % | Goldman Sachs Asset Management, L.P. | 615,892 | 138,100 | |
| 0.38186 % | Pictet Asset Management Ltd. | 608,640 | -9,910 | |
| 0.36947 % | Eversept Partners, LP | 588,900 | 71,879 | |
| 0.36322 % | Barclays Bank PLC | 578,939 | 256,939 | |
| 0.35566 % | AXA Investment Managers UK Ltd. | 566,883 | 397 | |
| 0.34364 % | UBS Asset Management (Switzerland) | 547,724 | 139,273 | |
| 0.32573 % | MFS Investment Management | 519,184 | -7,179 | |
| 0.31370 % | Great Point Partners, LLC | 500,000 | 250,000 | |
| 0.31370 % | Vestal Point Capital, LP | 500,000 | 500,000 | |
| 0.31027 % | Pinnacle Associates Ltd. | 494,539 | -113,978 | |
| 0.30623 % | RBC Wealth Management, International | 488,096 | 39,847 | |
| 0.29982 % | BMO Capital Markets (US) | 477,878 | -300,000 | |
| 0.29660 % | American Century Investment Management, Inc. | 472,749 | 355,981 | |
| 0.28249 % | Norges Bank Investment Management (NBIM) | 450,254 | -1,264,508 | |
| 0.28233 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 450,000 | 50,000 | |
| 0.28183 % | Schonfeld Strategic Advisors LLC | 449,206 | -111,153 | |
| 0.28159 % | GW&K Investment Management, LLC | 448,830 | 266,521 | |
| 0.28003 % | Parametric Portfolio Associates LLC | 446,346 | 78,085 | |
| 0.25516 % | abrdn Inc. | 406,694 | -39,503 | |
| 0.25370 % | Legal & General Investment Management Ltd. | 404,366 | 65,904 | |
| 0.25166 % | Medical Strategy GmbH | 401,113 | 24,278 | |
| 0.25073 % | Great Lakes Advisors, LLC | 399,646 | 399,646 | |
| 0.22270 % | Artisan Partners Limited Partnership | 354,962 | 151,784 | |
| 0.21393 % | Citi Investment Research (US) | 340,977 | -85,503 | |
| 0.20588 % | Columbia Threadneedle Investments (UK) | 328,157 | -2,073 | |
| 0.20197 % | Sovran Advisors LLC | 321,913 | -6,991 | |
| 0.20169 % | BlackRock Investment Management (UK) Ltd. | 321,471 | 46,276 | |
| 0.19863 % | Mellon Investments Corporation | 316,592 | 23,367 | |
| 0.18360 % | Point72 Asset Management, L.P. | 292,647 | 5,443 | |
| 0.18302 % | JPMorgan Asset Management U.K. Limited | 291,720 | -21,749 | |
| 0.18107 % | Schweizerische Nationalbank | 288,600 | 13,300 | |
| 0.17933 % | Sector Gamma AS | 285,842 | 0 | |
| 0.16984 % | Renaissance Technologies LLC | 270,714 | 117,200 | |
| 0.16789 % | Privium Fund Management BV | 267,594 | 0 | |
| 0.16676 % | Connor, Clark & Lunn Investment Management Ltd. | 265,793 | 136,520 | |
| 0.16665 % | AXA Investment Managers Paris | 265,619 | 0 | |
| 0.14928 % | Corient Private Wealth LLC | 237,931 | 798 | |
| 0.14599 % | Verition Fund Management LLC | 232,687 | 180,400 | |
| 0.14379 % | Nuveen LLC | 229,182 | -68,224 | |
| 0.13787 % | Morgan Stanley Smith Barney LLC | 219,746 | -8,097 | |
| 0.13638 % | Orion Investment Company | 217,370 | 2,080 | |
| 0.12673 % | California Public Employees' Retirement System | 201,993 | 10,989 | |
| 0.12583 % | BlackRock Asset Management Ireland Limited | 200,560 | -219,675 | |
| 0.12397 % | Edmond de Rothschild Asset Management (France) S.A. | 197,600 | 73,400 | |
| 0.12272 % | Stifel, Nicolaus & Company, Incorporated | 195,607 | -4,585 | |
| 0.12209 % | UBS Switzerland AG | 194,604 | 194,604 | |
| 0.11920 % | SELECTRA Management Company S.A. | 190,000 | 0 | |
| 0.11754 % | Tocqueville Asset Management LP | 187,345 | -50 | |
| 0.11625 % | Sicart Associates LLC | 185,296 | -350 | |
| 0.11419 % | Rhenman & Partners Asset Management AB | 182,000 | 101,000 | |
| 0.11399 % | RBC Capital Markets Wealth Management | 181,685 | 15,626 | |
| 0.11393 % | Rhumbline Advisers Ltd. Partnership | 181,599 | -6,617 | |
| 0.11297 % | Wells Fargo Advisors | 180,061 | -21,144 | |
| 0.11282 % | Monia (Brett P) | 179,820 | -1,160 | |
| 0.11153 % | BNP Paribas Securities Corp. North America | 177,762 | -130,531 | |
| 0.10634 % | BNY Mellon Asset Management | 169,501 | -49,778 | |
| 0.10237 % | Sonora Investment Management Group, LLC | 163,172 | 9,025 | |
| 0.10167 % | Goldman Sachs & Company, Inc. | 162,048 | -12,678 | |
| 0.09976 % | Alyeska Investment Group, L.P. | 159,008 | 159,008 | |
| 0.09918 % | Aquatic Capital Management LLC | 158,086 | 1,929 | |
| 0.09883 % | Aperio Group, LLC | 157,532 | 36,219 | |
| 0.09840 % | Nikko Asset Management Americas, Inc. | 156,834 | 156,834 | |