| 14.95421 % | Fidelity Management & Research Company LLC | 4,327,747 | 13,929 | |
| 12.15764 % | BlackRock Institutional Trust Company, N.A. | 3,518,421 | -115,652 | |
| 9.73683 % | The Vanguard Group, Inc. | 2,817,840 | -2,394 | |
| 9.19143 % | Avoro Capital Advisors LLC | 2,660,000 | -71,000 | |
| 5.69475 % | Krishnan (Krish S) | 1,648,060 | -25,000 | |
| 5.45511 % | Krishnan (Suma M) | 1,578,710 | -25,000 | |
| 4.68330 % | State Street Global Advisors (US) | 1,355,346 | 128,639 | |
| 3.25587 % | Capital World Investors | 942,249 | -12,219 | |
| 3.24502 % | Capital Research Global Investors | 939,109 | -13,117 | |
| 3.18921 % | Soleus Capital Management, L.P. | 922,958 | 481,200 | |
| 2.51490 % | Braidwell LP | 727,811 | 327,067 | |
| 2.37892 % | Frazier Life Sciences Management, L.P. | 688,460 | 0 | |
| 2.29257 % | Redmile Group, LLC | 663,471 | -74,204 | |
| 2.14080 % | Geode Capital Management, L.L.C. | 619,547 | 7,194 | |
| 1.84182 % | Hood River Capital Management LLC | 533,023 | 8,379 | |
| 1.74806 % | Dimensional Fund Advisors, L.P. | 505,889 | -28,030 | |
| 1.65720 % | Goldman Sachs & Company, Inc. | 479,595 | 314,825 | |
| 0.97687 % | Norges Bank Investment Management (NBIM) | 282,706 | 63,178 | |
| 0.85066 % | Charles Schwab Investment Management, Inc. | 246,180 | -4,334 | |
| 0.83056 % | T. Rowe Price Associates, Inc. | 240,363 | -150,838 | |
| 0.76838 % | First Trust Advisors L.P. | 222,370 | 189,245 | |
| 0.75214 % | Northern Trust Investments, Inc. | 217,670 | -10,501 | |
| 0.60560 % | Fidelity Investments Canada ULC | 175,262 | 1,265 | |
| 0.52044 % | Woodline Partners LP | 150,616 | -71,427 | |
| 0.51352 % | Segall Bryant & Hamill, LLC | 148,614 | 3,277 | |
| 0.51133 % | Readystate Asset Management LP | 147,980 | 147,980 | |
| 0.50082 % | Nuveen LLC | 144,936 | -45,364 | |
| 0.48735 % | Morgan Stanley & Co. LLC | 141,039 | -46,315 | |
| 0.48681 % | Principal Global Investors (Equity) | 140,883 | 14,546 | |
| 0.45106 % | Pictet Asset Management Ltd. | 130,537 | 65,275 | |
| 0.40663 % | UBS Asset Management (Americas) LLC | 117,679 | -129,323 | |
| 0.39462 % | TimesSquare Capital Management, LLC | 114,204 | -27,979 | |
| 0.39172 % | BofA Global Research (US) | 113,363 | 30,127 | |
| 0.38833 % | Marshall Wace LLP | 112,382 | 95,158 | |
| 0.37738 % | S Squared Technology, LLC | 109,215 | 12,000 | |
| 0.37576 % | Mellon Investments Corporation | 108,746 | -1,841 | |
| 0.37498 % | abrdn Inc. | 108,518 | 71,217 | |
| 0.37098 % | Janney (Daniel Spencer) | 107,362 | 0 | |
| 0.34554 % | Logos Global Management LP | 100,000 | 100,000 | |
| 0.34072 % | BlackRock Financial Management, Inc. | 98,605 | 4,970 | |
| 0.32935 % | UBS Asset Management (Switzerland) | 95,315 | -210,056 | |
| 0.31772 % | Barclays Bank PLC | 91,948 | 47,218 | |
| 0.31622 % | UBS Financial Services, Inc. | 91,514 | 28,700 | |
| 0.31479 % | William Blair Investment Management, LLC | 91,099 | 91,099 | |
| 0.31030 % | Renaissance Technologies LLC | 89,800 | 78,600 | |
| 0.29954 % | PSP Investments | 86,688 | 6,424 | |
| 0.29651 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 85,809 | 0 | |
| 0.28553 % | BlackRock Investment Management, LLC | 82,633 | 14,267 | |
| 0.27686 % | Victory Capital Management Inc. | 80,123 | 7,308 | |
| 0.27191 % | Rossi (Dino A) | 78,691 | 0 | |
| 0.27161 % | Parametric Portfolio Associates LLC | 78,605 | -14,207 | |
| 0.25875 % | BlackRock Advisors (UK) Limited | 74,883 | 2,154 | |
| 0.24448 % | Rhumbline Advisers Ltd. Partnership | 70,753 | 2,026 | |
| 0.23782 % | BlackRock Asset Management Ireland Limited | 68,824 | -9,775 | |
| 0.23633 % | Legal & General Investment Management Ltd. | 68,393 | 1,884 | |
| 0.23082 % | Handelsbanken Kapitalförvaltning AB | 66,800 | -7,500 | |
| 0.22806 % | Decheng Capital LLC | 66,000 | 1,000 | |
| 0.22504 % | Eagle Asset Management, Inc. | 65,127 | 2,758 | |
| 0.22112 % | Voya Investment Management LLC | 63,993 | -608 | |
| 0.21106 % | Columbia Threadneedle Investments (US) | 61,082 | 2,337 | |
| 0.21026 % | JPMorgan Asset Management U.K. Limited | 60,849 | -7,762 | |
| 0.20725 % | SEB Investment Management AB | 59,978 | 0 | |
| 0.18671 % | Medical Strategy GmbH | 54,035 | 24,529 | |
| 0.18636 % | Alyeska Investment Group, L.P. | 53,934 | 53,934 | |
| 0.18152 % | Citi Investment Research (US) | 52,533 | -20,992 | |
| 0.17542 % | Goldman Sachs Asset Management, L.P. | 50,766 | -18,104 | |
| 0.16448 % | Invesco Capital Management LLC | 47,601 | -47,051 | |
| 0.16357 % | BNY Mellon Asset Management | 47,338 | 1,349 | |
| 0.14887 % | Nuveen Asset Management, LLC | 43,083 | -797 | |
| 0.14642 % | Federated MDTA LLC | 42,373 | 29,681 | |
| 0.14305 % | Schweizerische Nationalbank | 41,400 | -400 | |
| 0.14008 % | Corient Private Wealth LLC | 40,538 | -1,589 | |
| 0.13892 % | Palisades Investment Partners, LLC | 40,203 | -493 | |
| 0.13254 % | Mutual of America Capital Management LLC | 38,357 | 1,926 | |
| 0.13181 % | Kennedy Capital Management LLC | 38,146 | -3,372 | |
| 0.12470 % | State of Wisconsin Investment Board | 36,089 | 11,906 | |
| 0.11978 % | Rafferty Asset Management LLC | 34,665 | 10,504 | |
| 0.11942 % | Citadel Advisors LLC | 34,560 | 34,464 | |
| 0.10753 % | AllianceBernstein L.P. | 31,120 | 0 | |
| 0.10532 % | AHL Partners LLP | 30,481 | 30,481 | |
| 0.10453 % | Susquehanna International Group, LLP | 30,252 | -3,577 | |
| 0.10427 % | GW&K Investment Management, LLC | 30,175 | -3,925 | |
| 0.10176 % | Aperio Group, LLC | 29,448 | -11,418 | |
| 0.10160 % | MFS Investment Management | 29,403 | -880 | |
| 0.09205 % | Los Angeles Capital Management LLC | 26,638 | 1,709 | |
| 0.09162 % | Verition Fund Management LLC | 26,514 | 7,889 | |
| 0.09036 % | PGIM Quantitative Solutions LLC | 26,151 | -360 | |
| 0.08528 % | Manulife Investment Management (North America) Limited | 24,680 | -7,686 | |
| 0.08419 % | Epoch Investment Partners, Inc. | 24,365 | 676 | |
| 0.08079 % | New York State Common Retirement Fund | 23,382 | 0 | |
| 0.08046 % | Invesco Advisers, Inc. | 23,285 | -136,549 | |
| 0.07905 % | EFG Asset Management (North America) Corp | 22,878 | 5,507 | |
| 0.07533 % | BlackRock Investment Management (UK) Ltd. | 21,801 | 9,255 | |
| 0.07339 % | Biondo Investment Advisors, LLC | 21,240 | 16,240 | |
| 0.07263 % | T. Rowe Price International Ltd | 21,020 | 1,360 | |
| 0.07204 % | Canada Life Asset Management Limited | 20,847 | -3,762 | |
| 0.07133 % | Synovus Trust Company, N.A. | 20,643 | 20,643 | |
| 0.06965 % | Healthinvest Partners AB | 20,158 | -3,333 | |
| 0.06954 % | California State Teachers Retirement System | 20,126 | 0 | |
| 0.06938 % | TD Asset Management Inc. | 20,080 | -20,188 | |