10.69727 % | The Vanguard Group, Inc. | 41,620,949 | 1,367,173 | |
5.67856 % | Baillie Gifford & Co. | 22,094,124 | -2,854,434 | |
5.04717 % | BlackRock Institutional Trust Company, N.A. | 19,637,528 | 1,762,948 | |
5.00161 % | Fidelity Management & Research Company LLC | 19,460,247 | -1,366,827 | |
4.43884 % | State Street Global Advisors (US) | 17,270,631 | -507,927 | |
3.79740 % | Two Sigma Investments, LP | 14,774,908 | 6,512,305 | |
2.36730 % | Boston Biotech Ventures, L.L.C. | 9,210,686 | 160,314 | |
2.28161 % | Geode Capital Management, L.L.C. | 8,877,280 | 1,420,690 | |
2.02241 % | Theleme Partners LLP | 7,868,810 | 626,420 | |
1.91826 % | D. E. Shaw & Co., L.P. | 7,463,555 | 1,827,404 | |
1.68728 % | OCHA, L.L.C. | 6,564,880 | 0 | |
1.61083 % | Invesco Capital Management LLC | 6,267,436 | 1,091,957 | |
1.41202 % | Bancel (Stephane J) | 5,493,897 | 0 | |
1.19054 % | Flagship Ventures | 4,632,149 | 0 | |
1.17319 % | Morgan Stanley & Co. LLC | 4,564,637 | 167,910 | |
0.97197 % | Jane Street Capital, L.L.C. | 3,781,759 | 193,722 | |
0.88414 % | Norges Bank Investment Management (NBIM) | 3,439,999 | -500,195 | |
0.87474 % | Voloridge Investment Management, LLC | 3,403,434 | 142,888 | |
0.80523 % | Banque Pictet & Cie S.A. | 3,132,974 | 0 | |
0.78136 % | Charles Schwab Investment Management, Inc. | 3,040,117 | 410,252 | |
0.73227 % | Susquehanna International Group, LLP | 2,849,112 | 1,620,401 | |
0.73223 % | Federated MDTA LLC | 2,848,944 | 2,232,933 | |
0.66154 % | BlackRock Asset Management Ireland Limited | 2,573,907 | -469,874 | |
0.65001 % | Parametric Portfolio Associates LLC | 2,529,068 | 593,944 | |
0.63926 % | Northern Trust Investments, Inc. | 2,487,243 | 42,631 | |
0.63436 % | BlackRock Financial Management, Inc. | 2,468,165 | 769,574 | |
0.62806 % | Citi Investment Research (US) | 2,443,644 | -65,288 | |
0.59324 % | Merck & Co Inc | 2,308,190 | 0 | |
0.57161 % | Afeyan (Noubar Boghos) | 2,224,015 | 382,084 | |
0.55767 % | BlackRock Investment Management (UK) Ltd. | 2,169,800 | 303,152 | |
0.53141 % | UBS Switzerland AG | 2,067,624 | -1,796,860 | |
0.48996 % | RBC Dominion Securities, Inc. | 1,906,344 | 1,863,608 | |
0.48076 % | UBS Financial Services, Inc. | 1,870,555 | -626,091 | |
0.47155 % | Citadel Advisors LLC | 1,834,708 | 74,423 | |
0.45753 % | Barclays Bank PLC | 1,780,158 | 763,594 | |
0.41333 % | Hoge (Stephen) | 1,608,168 | 1,392 | |
0.40738 % | Goldman Sachs Asset Management, L.P. | 1,585,017 | 187,150 | |
0.38179 % | BofA Global Research (US) | 1,485,457 | 520,123 | |
0.36655 % | Legal & General Investment Management Ltd. | 1,426,164 | -845,459 | |
0.35917 % | Capital Fund Management S.A. | 1,397,477 | 895,400 | |
0.34593 % | Jacobs Levy Equity Management, Inc. | 1,345,950 | 347,447 | |
0.33806 % | Goldman Sachs Bank AG | 1,315,332 | 320 | |
0.32409 % | TB Alternative Assets Ltd. | 1,260,953 | 608,580 | |
0.31836 % | Bellevue Asset Management AG | 1,238,668 | -279,454 | |
0.31689 % | First Trust Advisors L.P. | 1,232,952 | 318,183 | |
0.31488 % | BNP Paribas Securities Corp. North America | 1,225,135 | -222,939 | |
0.28956 % | UBS Asset Management (Switzerland) | 1,126,610 | -238,912 | |
0.28662 % | DWS Investments UK Limited | 1,115,187 | -290,089 | |
0.28515 % | Dimensional Fund Advisors, L.P. | 1,109,467 | -421,563 | |
0.25802 % | Renaissance Technologies LLC | 1,003,900 | -356,200 | |
0.25702 % | Deerfield Management Company, L.P. | 1,000,000 | 1,000,000 | |
0.24102 % | UBS Asset Management (UK) Ltd. | 937,765 | -173,884 | |
0.23907 % | Douglas C. Lane & Associates | 930,165 | 56,648 | |
0.23599 % | Letko, Brosseau & Associates Inc. | 918,190 | 21,765 | |
0.23374 % | Amundi Asset Management, SAS | 909,429 | -424,445 | |
0.23342 % | Nuveen LLC | 908,207 | 245,010 | |
0.22347 % | Millennium Management LLC | 869,492 | 720,698 | |
0.21605 % | WorldQuant Millennium Advisors LLC | 840,595 | 840,595 | |
0.21485 % | J.P. Morgan Securities LLC | 835,925 | 827,279 | |
0.21313 % | Invesco Advisers, Inc. | 829,248 | 139,078 | |
0.20535 % | J.P. Morgan Securities plc | 798,972 | 627,866 | |
0.19098 % | Sessa Capital | 743,081 | 0 | |
0.18877 % | RBC Capital Markets Wealth Management | 734,464 | 130,568 | |
0.18857 % | Pictet & Cie (Europe) S.A. | 733,686 | 204,000 | |
0.18477 % | Mellon Investments Corporation | 718,884 | -295,094 | |
0.18063 % | BNY Mellon Asset Management | 702,792 | -75,837 | |
0.17541 % | Pictet Asset Management Ltd. | 682,499 | 2,751 | |
0.17058 % | Schweizerische Nationalbank | 663,700 | -258,800 | |
0.16567 % | Acadian Asset Management LLC | 644,571 | 477,072 | |
0.16008 % | Rhumbline Advisers Ltd. Partnership | 622,857 | 25,390 | |
0.15500 % | BlackRock Investment Management, LLC | 603,071 | 153,143 | |
0.15450 % | CPP Investment Board | 601,146 | 232,874 | |
0.15232 % | UBS Asset Management (Americas) LLC | 592,651 | -288,930 | |
0.15220 % | National Bank of Canada | 592,194 | -432,917 | |
0.14371 % | SG Americas Securities, L.L.C. | 559,129 | 487,734 | |
0.13767 % | Tudor Investment Corporation | 535,665 | 219,273 | |
0.13292 % | Suvretta Capital Management, LLC | 517,163 | 0 | |
0.12982 % | Pictet Asset Management (Japan) Ltd. | 505,105 | -44,777 | |
0.12904 % | HSBC Global Asset Management (UK) Limited | 502,083 | -49,626 | |
0.12734 % | Goldman Sachs & Company, Inc. | 495,463 | 7,747 | |
0.12700 % | Sagan (Paul L) | 494,133 | 31,620 | |
0.12186 % | T. Rowe Price International Ltd | 474,138 | -18,773 | |
0.11442 % | California Public Employees' Retirement System | 445,190 | 73,654 | |
0.11412 % | Aperio Group, LLC | 444,034 | 57,031 | |
0.11275 % | IMC Chicago, LLC | 438,683 | -53,574 | |
0.11239 % | Morgan Stanley Smith Barney LLC | 437,290 | -167,420 | |
0.10992 % | AllianceBernstein L.P. | 427,664 | 73,896 | |
0.10692 % | Mitsubishi UFJ Asset Management Co., Ltd. | 416,020 | -243,230 | |
0.10374 % | BlackRock (Netherlands) B.V. | 403,644 | -511,969 | |
0.10142 % | Rafferty Asset Management LLC | 394,599 | 45,740 | |
0.10048 % | Manulife Investment Management (North America) Limited | 390,954 | 688 | |
0.09813 % | Simplex Trading, LLC | 381,787 | 190,557 | |
0.09604 % | Group One Trading, L.P. | 373,688 | -70,750 | |
0.09589 % | Lingotto Investment Management LLP | 373,095 | 0 | |
0.09551 % | Principal Global Investors (Equity) | 371,612 | -9 | |
0.09332 % | JPMorgan Private Bank (United States) | 363,106 | 6,010 | |
0.09145 % | UBS Fund Management (Switzerland) AG | 355,821 | 124,767 | |
0.08858 % | Boston Management and Research | 344,651 | 0 | |
0.08415 % | California State Teachers Retirement System | 327,429 | -168,739 | |
0.08232 % | Bank Vontobel AG | 320,276 | 63,503 | |