| 17.57329 % | Frazier Life Sciences Management, L.P. | 12,466,489 | 492,632 | |
| 10.52237 % | Medicxi Ventures (UK) LLP | 7,464,572 | 0 | |
| 5.30314 % | Millennium Management LLC | 3,762,044 | 1,511,547 | |
| 4.92925 % | Abingworth Management Limited | 3,496,808 | 0 | |
| 4.57330 % | Invesco Advisers, Inc. | 3,244,299 | -107,390 | |
| 4.22308 % | BlackRock Institutional Trust Company, N.A. | 2,995,851 | 86,332 | |
| 3.92911 % | The Vanguard Group, Inc. | 2,787,311 | 18,033 | |
| 3.55226 % | Ensign Peak Advisors, Inc. | 2,519,972 | 5,688 | |
| 2.96730 % | 683 Capital Management LLC | 2,105,000 | 660,000 | |
| 2.76314 % | New Enterprise Associates (NEA) | 1,960,169 | 0 | |
| 2.06075 % | Wasatch Global Investors Inc | 1,461,895 | -239,732 | |
| 1.73563 % | Socks (David A) | 1,231,256 | 0 | |
| 1.64521 % | Catalys Pacific, LLC | 1,167,114 | 0 | |
| 1.50821 % | Geode Capital Management, L.L.C. | 1,069,927 | 53,504 | |
| 1.50056 % | Avidity Partners Management LP | 1,064,500 | 264,500 | |
| 1.47797 % | GW&K Investment Management, LLC | 1,048,472 | -55,836 | |
| 1.31003 % | Nabulsi (Azmi) | 929,335 | -24,060 | |
| 1.30100 % | Propel Bio Management, LLC | 922,927 | -212,000 | |
| 1.19738 % | State Street Global Advisors (US) | 849,424 | -51,930 | |
| 0.94769 % | Catalio Capital Management, LP | 672,290 | 672,290 | |
| 0.85205 % | Invesco Capital Management LLC | 604,447 | 601,587 | |
| 0.84579 % | Moore Capital Management, LP | 600,000 | 600,000 | |
| 0.73574 % | Simplify Asset Management Inc | 521,935 | -160,000 | |
| 0.72913 % | Citi Investment Research (US) | 517,247 | -13,612 | |
| 0.71138 % | Medical Strategy GmbH | 504,654 | 173,486 | |
| 0.59499 % | StepStone Group LP | 422,085 | 0 | |
| 0.51354 % | Curran (Terrie) | 364,305 | 281,388 | |
| 0.50770 % | Charles Schwab Investment Management, Inc. | 360,160 | 12,125 | |
| 0.47774 % | Northern Trust Investments, Inc. | 338,908 | -8,713 | |
| 0.43191 % | Schonfeld Strategic Advisors LLC | 306,399 | 306,399 | |
| 0.41867 % | UBS Financial Services, Inc. | 297,003 | -285,405 | |
| 0.41067 % | Invesco Canada Ltd. | 291,326 | -4,937 | |
| 0.26401 % | Woodline Partners LP | 187,291 | -564,401 | |
| 0.25494 % | Columbia Threadneedle Investments (US) | 180,851 | 180,851 | |
| 0.24077 % | Goldman Sachs & Company, Inc. | 170,804 | 93,964 | |
| 0.20764 % | RBC Dominion Securities, Inc. | 147,298 | 147,298 | |
| 0.20497 % | BlackRock Investment Management, LLC | 145,409 | 31,363 | |
| 0.18919 % | Susquehanna International Group, LLP | 134,208 | -26,930 | |
| 0.17264 % | UBS Switzerland AG | 122,470 | -2,700 | |
| 0.16916 % | Advisory Invest GmbH | 120,000 | 40,000 | |
| 0.15999 % | Parikh (Asit) | 113,500 | 10,500 | |
| 0.15936 % | JP Morgan Asset Management | 113,049 | -1,023 | |
| 0.15344 % | Nuveen LLC | 108,853 | 9,133 | |
| 0.14103 % | Morgan Stanley & Co. LLC | 100,044 | -921,430 | |
| 0.14006 % | BlackRock Financial Management, Inc. | 99,356 | -11,841 | |
| 0.13544 % | BofA Global Research (US) | 96,080 | 234 | |
| 0.12797 % | State of Wisconsin Investment Board | 90,781 | -8,995 | |
| 0.11805 % | BNY Mellon Asset Management | 83,743 | 5,810 | |
| 0.11750 % | MFS Investment Management | 83,351 | 0 | |
| 0.10834 % | Barclays Bank PLC | 76,859 | 23,057 | |
| 0.09515 % | Karbe (Frank L) | 67,500 | 10,500 | |
| 0.09100 % | Rhumbline Advisers Ltd. Partnership | 64,557 | 7,818 | |
| 0.08941 % | Adar1 Capital Management LLC | 63,424 | 20,624 | |
| 0.08853 % | Penn Mutual Asset Management, LLC | 62,802 | 0 | |
| 0.08851 % | Henderson (Molly) | 62,790 | -48,018 | |
| 0.08072 % | Creative Planning, Inc. | 57,264 | -2,673 | |
| 0.07486 % | Parametric Portfolio Associates LLC | 53,105 | -55,417 | |
| 0.07131 % | AllianceBernstein L.P. | 50,590 | 5,000 | |
| 0.07037 % | AQR Capital Management, LLC | 49,924 | -57,475 | |
| 0.06822 % | Breedlove (Robert Charles) | 48,392 | -1,692 | |
| 0.06556 % | Topper (James N) | 46,508 | 10,500 | |
| 0.06246 % | Virtus Investment Advisers, Inc. | 44,306 | -658 | |
| 0.05770 % | BlackRock Advisors (UK) Limited | 40,932 | 6,290 | |
| 0.05761 % | Geneva Capital Management LLC | 40,866 | 1,724 | |
| 0.05680 % | Diadema Partners LP | 40,294 | 40,294 | |
| 0.05610 % | Cola (Michael F) | 39,798 | 10,500 | |
| 0.05608 % | Aperio Group, LLC | 39,784 | -57,504 | |
| 0.05348 % | Nebula Research & Development LLC | 37,937 | 9,116 | |
| 0.05160 % | Mellon Investments Corporation | 36,603 | 1 | |
| 0.04880 % | BlackRock Asset Management Ireland Limited | 34,622 | -34,409 | |
| 0.04540 % | Quest Partners, LLC | 32,206 | 30,760 | |
| 0.04448 % | Commonwealth Financial Network | 31,556 | -20,875 | |
| 0.04420 % | Gilder Gagnon Howe & Co. LLC | 31,358 | -10,208 | |
| 0.04390 % | Summit Financial Wealth Advisors, Llc | 31,143 | -36,982 | |
| 0.04244 % | T. Rowe Price International Ltd | 30,104 | 3,091 | |
| 0.04237 % | Kera Capital Partners, Inc. | 30,059 | 210 | |
| 0.04229 % | Stenhouse (Mark) | 30,000 | 10,500 | |
| 0.04229 % | Fields-Kunz (Heidi) | 30,000 | 10,500 | |
| 0.04183 % | Occidental Asset Management, LLC | 29,672 | 0 | |
| 0.03974 % | INTECH Investment Management LLC | 28,192 | 6,708 | |
| 0.03924 % | Brevan Howard Capital Management LP | 27,834 | 27,834 | |
| 0.03669 % | Mirae Asset Global Investments (USA) LLC | 26,031 | 580 | |
| 0.03652 % | DWS Investments UK Limited | 25,909 | -1,093 | |
| 0.03643 % | MetLife Investment Management, LLC | 25,845 | 1,479 | |
| 0.03620 % | Wells Fargo Bank, N.A. | 25,678 | 2,803 | |
| 0.03524 % | Birchview Capital, LP | 25,000 | 25,000 | |
| 0.03442 % | Assenagon Asset Management S.A. | 24,420 | 72 | |
| 0.03270 % | UBS Asset Management (Americas) LLC | 23,200 | 23,200 | |
| 0.03256 % | Putnam Investment Management, L.L.C. | 23,100 | 23,100 | |
| 0.03062 % | Goldman Sachs Asset Management, L.P. | 21,722 | -89,312 | |
| 0.02960 % | Wells Fargo Advisors | 21,000 | 15,450 | |
| 0.02960 % | Schroeder (Theodore R) | 21,000 | 21,000 | |
| 0.02885 % | Stifel, Nicolaus & Company, Incorporated | 20,467 | 3,069 | |
| 0.02882 % | Allworth Financial, L.P. | 20,448 | -30 | |
| 0.02813 % | JPMorgan Private Bank (United States) | 19,953 | 1,099 | |
| 0.02797 % | Florida State Board of Administration | 19,845 | 0 | |
| 0.02793 % | Inspirion Wealth Advisors, LLC | 19,814 | -50 | |
| 0.02753 % | Corebridge Financial Inc. | 19,532 | 24 | |
| 0.02749 % | Kunz (Heidi K.) | 19,500 | 10,500 | |
| 0.02231 % | Manulife Investment Management (North America) Limited | 15,826 | 1,364 | |