| 13.59574 % | BlackRock Institutional Trust Company, N.A. | 8,457,909 | -140,214 | |
| 9.92124 % | Farallon Capital Management, L.L.C. | 6,172,006 | 65,000 | |
| 9.25298 % | RTW Investments L.P. | 5,756,277 | 36,862 | |
| 6.98776 % | The Vanguard Group, Inc. | 4,347,084 | 80,380 | |
| 5.21765 % | Deep Track Capital LP | 3,245,899 | -4,101 | |
| 5.16162 % | BVF Partners L.P. | 3,211,041 | 636,026 | |
| 5.15599 % | State Street Global Advisors (US) | 3,207,543 | 500,924 | |
| 4.02066 % | UBS Financial Services, Inc. | 2,501,251 | 2,153,380 | |
| 3.93696 % | Johnson & Johnson Innovation-JJDC, Inc. | 2,449,183 | 0 | |
| 2.32154 % | Geode Capital Management, L.L.C. | 1,444,230 | 20,671 | |
| 1.75577 % | Adage Capital Management, L.P. | 1,092,262 | 748,758 | |
| 1.72802 % | Commodore Capital LP | 1,075,000 | 1,075,000 | |
| 1.72713 % | Perceptive Advisors LLC | 1,074,448 | -16,823 | |
| 1.66812 % | Wellington Management Company, LLP | 1,037,738 | 50,368 | |
| 1.52398 % | Adar1 Capital Management LLC | 948,069 | 8,400 | |
| 1.52208 % | Woodline Partners LP | 946,884 | 49,185 | |
| 1.42270 % | T. Rowe Price Associates, Inc. | 885,062 | -388,701 | |
| 1.32458 % | Jefferies LLC | 824,019 | 192,126 | |
| 1.30846 % | American Century Investment Management, Inc. | 813,995 | 128,171 | |
| 1.29725 % | BofA Global Research (US) | 807,020 | 376,831 | |
| 1.21799 % | Driehaus Capital Management, LLC | 757,710 | 522,637 | |
| 1.20877 % | Pictet Asset Management Ltd. | 751,977 | 456,384 | |
| 1.17829 % | Lynx1 Capital Advisors LLC | 733,014 | 0 | |
| 1.08465 % | Morgan Stanley & Co. LLC | 674,762 | 345,920 | |
| 0.92487 % | Charles Schwab Investment Management, Inc. | 575,364 | 17,646 | |
| 0.92058 % | BlackRock Financial Management, Inc. | 572,695 | -65,321 | |
| 0.91472 % | Goldman Sachs & Company, Inc. | 569,049 | 107,407 | |
| 0.86551 % | Fidelity Management & Research Company LLC | 538,432 | 60,089 | |
| 0.85248 % | Holocene Advisors, LP | 530,326 | 530,326 | |
| 0.85154 % | Northern Trust Investments, Inc. | 529,742 | -31,459 | |
| 0.83634 % | Invesco Capital Management LLC | 520,286 | -144,284 | |
| 0.71826 % | Janus Henderson Investors | 446,828 | 425,374 | |
| 0.71616 % | BNP Paribas Asset Management USA, Inc. | 445,523 | 65,874 | |
| 0.71603 % | TD Securities, Inc. | 445,440 | 0 | |
| 0.71532 % | 683 Capital Management LLC | 445,000 | -55,000 | |
| 0.70728 % | Affinity Asset Advisors LLC | 440,000 | 40,000 | |
| 0.67247 % | Gratus Capital LLC | 418,346 | 10,173 | |
| 0.65206 % | Jupiter Asset Management Ltd. | 405,644 | 237,581 | |
| 0.63693 % | JP Morgan Asset Management | 396,233 | -19,926 | |
| 0.63556 % | Mangrove Partners | 395,383 | 0 | |
| 0.53068 % | Principal Global Investors (Equity) | 330,134 | -16,961 | |
| 0.50509 % | Patel (Dinesh V) | 314,219 | -42,859 | |
| 0.48413 % | Eagle Asset Management, Inc. | 301,176 | 13,230 | |
| 0.45066 % | Voya Investment Management LLC | 280,354 | 220,676 | |
| 0.44577 % | Eversept Partners, LP | 277,316 | -269,800 | |
| 0.42010 % | Mellon Investments Corporation | 261,345 | 3,106 | |
| 0.39288 % | Gupta (Suneel) | 244,412 | 14,147 | |
| 0.36869 % | BlackRock Advisors (UK) Limited | 229,359 | 5,850 | |
| 0.34527 % | BlackRock Asset Management Ireland Limited | 214,791 | 16,426 | |
| 0.34110 % | Medical Strategy GmbH | 212,200 | 10,200 | |
| 0.33963 % | PSP Investments | 211,281 | 22,250 | |
| 0.33581 % | BlackRock Investment Management, LLC | 208,906 | 31,792 | |
| 0.33277 % | Barclays Bank PLC | 207,015 | 113,826 | |
| 0.32894 % | Goldman Sachs Asset Management, L.P. | 204,634 | 110,725 | |
| 0.32350 % | Invesco Advisers, Inc. | 201,248 | 7,673 | |
| 0.28942 % | Dimensional Fund Advisors, L.P. | 180,050 | 58,496 | |
| 0.27831 % | Renaissance Technologies LLC | 173,134 | -150,433 | |
| 0.27814 % | Rhumbline Advisers Ltd. Partnership | 173,028 | 10,963 | |
| 0.27418 % | Moody Aldrich Partners, LLC | 170,570 | 7,087 | |
| 0.27194 % | Parametric Portfolio Associates LLC | 169,173 | 17,528 | |
| 0.27065 % | Columbia Threadneedle Investments (US) | 168,371 | 31,529 | |
| 0.26713 % | Legal & General Investment Management Ltd. | 166,181 | 18,074 | |
| 0.23917 % | PanAgora Asset Management Inc. | 148,790 | -1,118 | |
| 0.22407 % | Great Lakes Advisors, LLC | 139,391 | -12,927 | |
| 0.21709 % | Nan Fung Trinity (HK) Limited | 135,050 | 135,050 | |
| 0.21683 % | Kennedy Capital Management LLC | 134,890 | -2,614 | |
| 0.19843 % | Nuveen LLC | 123,444 | -24,387 | |
| 0.19315 % | Segall Bryant & Hamill, LLC | 120,159 | 120,159 | |
| 0.18700 % | TD Asset Management Inc. | 116,332 | -53,600 | |
| 0.18663 % | Capitolis Liquid Global Markets LLC | 116,100 | 116,100 | |
| 0.18555 % | UBS Asset Management (Switzerland) | 115,431 | 47,972 | |
| 0.18310 % | First Trust Advisors L.P. | 113,907 | 32,221 | |
| 0.18146 % | BNY Mellon Asset Management | 112,886 | 3,235 | |
| 0.16878 % | Opaleye Management Inc. | 105,000 | 0 | |
| 0.15239 % | Manulife Investment Management (North America) Limited | 94,801 | -26,049 | |
| 0.15078 % | Schweizerische Nationalbank | 93,800 | 6,900 | |
| 0.15043 % | Neuberger Berman, LLC | 93,582 | 93,582 | |
| 0.14769 % | Assenagon Asset Management S.A. | 91,875 | 47,003 | |
| 0.14752 % | Aperio Group, LLC | 91,772 | 30,235 | |
| 0.14617 % | Victory Capital Management Inc. | 90,932 | -11,479 | |
| 0.13302 % | SEB Investment Management AB | 82,750 | -166,200 | |
| 0.13137 % | EFG Asset Management (North America) Corp | 81,726 | 10,592 | |
| 0.13070 % | Checkpoint Capital L.P. | 81,311 | -93,873 | |
| 0.12947 % | Rafferty Asset Management LLC | 80,543 | 36,286 | |
| 0.12860 % | Knott Partners Management, LLC | 80,000 | 4,000 | |
| 0.12682 % | Northwestern Mutual Capital, LLC | 78,894 | 0 | |
| 0.12586 % | Franklin Advisers, Inc. | 78,298 | 2,130 | |
| 0.12530 % | Citi Investment Research (US) | 77,951 | -43,893 | |
| 0.12388 % | Schonfeld Strategic Advisors LLC | 77,068 | -210,233 | |
| 0.12250 % | PGIM Quantitative Solutions LLC | 76,208 | 17,850 | |
| 0.12246 % | Diadema Partners LP | 76,185 | 76,185 | |
| 0.11646 % | BlackRock Investment Management (UK) Ltd. | 72,448 | 22,144 | |
| 0.11569 % | The Informed Momentum Company LLC | 71,971 | 2,790 | |
| 0.11452 % | Susquehanna International Group, LLP | 71,241 | -120,998 | |
| 0.11333 % | DWS Investment GmbH | 70,500 | 50,000 | |
| 0.11208 % | EAM Global Investors LLC | 69,726 | -24 | |
| 0.11089 % | Qube Research & Technologies Ltd | 68,983 | -274,428 | |
| 0.10963 % | RBC Dominion Securities, Inc. | 68,200 | 68,200 | |
| 0.10915 % | AllianceBernstein L.P. | 67,900 | 0 | |
| 0.10721 % | Allianz Global Investors GmbH | 66,695 | -2,140 | |