| 9.12197 % | BlackRock Institutional Trust Company, N.A. | 9,840,327 | 937,081 | |
| 8.46707 % | The Vanguard Group, Inc. | 9,133,849 | 126,602 | |
| 4.69053 % | D. E. Shaw & Co., L.P. | 5,059,912 | 581,274 | |
| 4.35228 % | State Street Global Advisors (US) | 4,695,027 | 626,555 | |
| 3.84466 % | Two Sigma Investments, LP | 4,147,431 | 3,314,237 | |
| 2.97964 % | Barry (Richard J) | 3,214,284 | 32,596 | |
| 2.34573 % | Wellington Management Company, LLP | 2,530,455 | -116,164 | |
| 1.73905 % | Geode Capital Management, L.L.C. | 1,875,997 | 55,076 | |
| 1.50305 % | Erste Asset Management GmbH | 1,621,415 | 560,350 | |
| 1.48178 % | Qube Research & Technologies Ltd | 1,598,472 | 1,566,564 | |
| 1.36654 % | Voloridge Investment Management, LLC | 1,474,155 | 1,016,827 | |
| 1.19630 % | Federated MDTA LLC | 1,290,505 | 1,286,494 | |
| 1.15171 % | abrdn Inc. | 1,242,404 | 592,125 | |
| 1.14368 % | BNP Paribas Securities Corp. North America | 1,233,749 | 1,199,741 | |
| 1.01504 % | BlackRock Financial Management, Inc. | 1,094,974 | 749,569 | |
| 0.98466 % | Millennium Management LLC | 1,062,205 | 855,260 | |
| 0.91782 % | Casdin Capital, LLC | 990,097 | 89,314 | |
| 0.90957 % | Morgan Stanley & Co. LLC | 981,203 | -477,198 | |
| 0.84673 % | Norges Bank Investment Management (NBIM) | 913,407 | -125,454 | |
| 0.80666 % | Y-Intercept (Hong Kong) Ltd | 870,181 | 822,799 | |
| 0.80458 % | Assenagon Asset Management S.A. | 867,939 | 155,358 | |
| 0.76980 % | BofA Global Research (US) | 830,419 | 316,128 | |
| 0.74520 % | Dimensional Fund Advisors, L.P. | 803,888 | 217,570 | |
| 0.62691 % | Jane Street Capital, L.L.C. | 676,277 | 521,225 | |
| 0.62572 % | 683 Capital Management LLC | 675,000 | 510,000 | |
| 0.62468 % | Charles Schwab Investment Management, Inc. | 673,877 | 27,586 | |
| 0.59266 % | Thrivent Asset Management, LLC | 639,332 | 14,444 | |
| 0.58863 % | Northern Trust Investments, Inc. | 634,986 | -2,296 | |
| 0.58175 % | First Trust Advisors L.P. | 627,561 | 233,391 | |
| 0.57889 % | Renaissance Technologies LLC | 624,478 | 624,478 | |
| 0.57051 % | Connor, Clark & Lunn Investment Management Ltd. | 615,441 | 370,672 | |
| 0.55923 % | Jump Financial, LLC | 603,269 | 597,484 | |
| 0.47717 % | Capital Fund Management S.A. | 514,745 | 314,608 | |
| 0.46350 % | Opaleye Management Inc. | 500,000 | 500,000 | |
| 0.46196 % | Capital International Investors | 498,337 | -8,562,435 | |
| 0.45453 % | C WorldWide Asset Management Fondsmaeglerselskab A/S | 490,329 | 240,000 | |
| 0.45340 % | ING Bank N.V. | 489,100 | 489,100 | |
| 0.44055 % | UBS Financial Services, Inc. | 475,247 | -971,211 | |
| 0.44010 % | T. Rowe Price Investment Management, Inc. | 474,758 | -1,523,233 | |
| 0.41630 % | Ikarian Capital LLC | 449,087 | 280,000 | |
| 0.41226 % | Balyasny Asset Management LP | 444,728 | 444,728 | |
| 0.40438 % | Walleye Capital LLC | 436,225 | 423,278 | |
| 0.38962 % | Tang Capital Management, LLC | 420,300 | 420,300 | |
| 0.37899 % | BlackRock Investment Management, LLC | 408,832 | 222,728 | |
| 0.36181 % | Ingram (Douglas S) | 390,307 | 0 | |
| 0.35921 % | Trexquant Investment LP | 387,497 | 199,513 | |
| 0.34160 % | J.P. Morgan Securities LLC | 368,503 | 318,405 | |
| 0.33622 % | Mellon Investments Corporation | 362,701 | -42,155 | |
| 0.32511 % | BlackRock Asset Management Ireland Limited | 350,713 | 69,602 | |
| 0.32303 % | Columbia Wanger Asset Management, LLC | 348,472 | 124,923 | |
| 0.31380 % | Goldman Sachs & Company, Inc. | 338,517 | 236,434 | |
| 0.31035 % | Fiera Capital Inc. | 334,794 | -1,730 | |
| 0.29821 % | MPM BioImpact LLC | 321,696 | 321,696 | |
| 0.28010 % | Citadel Advisors LLC | 302,156 | 66,368 | |
| 0.27097 % | Chambers (Michael Andrew) | 292,311 | 38,137 | |
| 0.27058 % | Barclays Bank PLC | 291,888 | -118,310 | |
| 0.26857 % | Quinn Opportunity Partners LLC | 289,722 | 289,722 | |
| 0.26234 % | RBC Dominion Securities, Inc. | 282,998 | 265,193 | |
| 0.26182 % | Jain Global LLC | 282,437 | 282,437 | |
| 0.25965 % | TwinBeech Capital LP | 280,096 | 15,100 | |
| 0.25406 % | Parametric Portfolio Associates LLC | 274,063 | 70,688 | |
| 0.25284 % | Wells Fargo Advisors | 272,751 | 124,155 | |
| 0.24853 % | Hudson Bay Capital Management LP | 268,100 | 67,850 | |
| 0.24780 % | Rhumbline Advisers Ltd. Partnership | 267,314 | 2,070 | |
| 0.24083 % | Deep Track Capital LP | 259,800 | -639,931 | |
| 0.22668 % | Jacobs Levy Equity Management, Inc. | 244,533 | 244,533 | |
| 0.21767 % | Legal & General Investment Management Ltd. | 234,810 | 26,540 | |
| 0.21492 % | Franklin Advisers, Inc. | 231,840 | -1,795 | |
| 0.21203 % | Bank of Nova Scotia | 228,731 | 228,731 | |
| 0.20754 % | Principal Global Investors (Equity) | 223,886 | -20,880 | |
| 0.20109 % | BlackRock Investment Management (UK) Ltd. | 216,922 | 116,284 | |
| 0.20006 % | Aquatic Capital Management LLC | 215,817 | 123,501 | |
| 0.19561 % | BNY Mellon Asset Management | 211,019 | -25,228 | |
| 0.19497 % | Citi Investment Research (US) | 210,320 | -173,507 | |
| 0.19496 % | Adar1 Capital Management LLC | 210,313 | 87,392 | |
| 0.19395 % | Morgan Stanley Smith Barney LLC | 209,223 | 78,562 | |
| 0.18800 % | Amundi Asset Management, SAS | 202,800 | 186,177 | |
| 0.18641 % | Behrens (M Kathleen) | 201,093 | -537 | |
| 0.18489 % | Dark Forest Capital Management LP | 199,446 | 194,464 | |
| 0.17938 % | UBS Asset Management (Switzerland) | 193,503 | -1,367 | |
| 0.16709 % | Susquehanna International Group, LLP | 180,246 | 121,470 | |
| 0.16561 % | Pictet Asset Management Ltd. | 178,651 | -758,372 | |
| 0.15433 % | Schweizerische Nationalbank | 166,483 | 0 | |
| 0.15376 % | Nuveen LLC | 165,869 | -180,515 | |
| 0.14942 % | Pictet Asset Management (Japan) Ltd. | 161,187 | -47,243 | |
| 0.14866 % | RBC Wealth Management, International | 160,366 | -215,677 | |
| 0.14769 % | Sphera Funds Management Ltd. | 159,323 | 1,392 | |
| 0.14226 % | Boothbay Fund Management, LLC | 153,460 | 100,546 | |
| 0.13897 % | Algert Global LLC | 149,910 | 73,241 | |
| 0.13883 % | Rafferty Asset Management LLC | 149,760 | 50,655 | |
| 0.13757 % | AllianceBernstein L.P. | 148,409 | 15,285 | |
| 0.13436 % | Invesco Capital Management LLC | 144,941 | 35,517 | |
| 0.13240 % | Engineers Gate Manager, L.P. | 142,827 | 67,430 | |
| 0.13194 % | Group One Trading, L.P. | 142,334 | 89,779 | |
| 0.12737 % | Swedbank Robur Fonder AB | 137,400 | 0 | |
| 0.12504 % | Medical Strategy GmbH | 134,885 | 5,200 | |
| 0.12329 % | State Street Global Advisors Ireland Limited | 133,002 | -6,869 | |
| 0.12010 % | New York State Common Retirement Fund | 129,562 | 0 | |
| 0.11849 % | Squarepoint Capital LLP | 127,824 | -124,632 | |
| 0.11678 % | AQR Capital Management, LLC | 125,979 | 120,594 | |