| 9.98401 % | ARK Investment Management LLC | 5,567,224 | -468,467 | |
| 7.03840 % | EcoR1 Capital, LLC | 3,924,713 | 0 | |
| 5.28224 % | Atlas Venture | 2,945,453 | 0 | |
| 4.14137 % | The Vanguard Group, Inc. | 2,309,286 | 816 | |
| 2.85860 % | Lilly Ventures | 1,593,997 | -1,853,820 | |
| 1.95898 % | Acadian Asset Management LLC | 1,092,356 | 191,527 | |
| 1.94483 % | Goldman Sachs & Company, Inc. | 1,084,467 | -183,780 | |
| 1.92250 % | Nikko Asset Management Co., Ltd. | 1,072,013 | -32,217 | |
| 1.87613 % | Citi Investment Research (US) | 1,046,157 | -615 | |
| 1.40420 % | Dafna Capital Management, LLC | 783,000 | -317,000 | |
| 1.28073 % | Renaissance Technologies LLC | 714,155 | -271,188 | |
| 1.19330 % | Laurion Capital Management LP | 665,400 | 0 | |
| 1.09611 % | Citadel Advisors LLC | 611,207 | -780,029 | |
| 1.02684 % | BlackRock Institutional Trust Company, N.A. | 572,582 | -334,317 | |
| 0.77051 % | Tang Capital Management, LLC | 429,647 | 429,647 | |
| 0.75218 % | Stifel Nicolaus Investment Advisors | 419,425 | -10,940 | |
| 0.74473 % | Millennium Management LLC | 415,270 | 41,760 | |
| 0.69279 % | Geode Capital Management, L.L.C. | 386,312 | 13,698 | |
| 0.62767 % | Macquarie Investment Management | 350,000 | 0 | |
| 0.50744 % | Knights of Columbus | 282,953 | -321 | |
| 0.49569 % | GSA Capital Partners LLP | 276,403 | 156,020 | |
| 0.41820 % | Fidelity Management & Research Company LLC | 233,193 | -140,453 | |
| 0.36237 % | Dimensional Fund Advisors, L.P. | 202,064 | 0 | |
| 0.32922 % | XTX Markets LLC | 183,579 | -182,642 | |
| 0.30768 % | State Street Global Advisors (US) | 171,566 | 0 | |
| 0.30577 % | ACT Capital Management, L.L.C. | 170,500 | 0 | |
| 0.28245 % | Bridgeway Capital Management, LLC | 157,500 | -25,000 | |
| 0.25863 % | Kingsbury Capital Investment Advisors, LLC | 144,217 | 59,051 | |
| 0.23595 % | Jane Street Capital, L.L.C. | 131,569 | 131,569 | |
| 0.23174 % | Goater (J Jeffrey) | 129,222 | 129,222 | |
| 0.21762 % | Newton Investment Management North America, LLC | 121,350 | 0 | |
| 0.20790 % | Boston Advisors, LLC | 115,930 | 0 | |
| 0.19969 % | Fees (Jessica) | 111,349 | -5,980 | |
| 0.19893 % | Marshall Wace LLP | 110,928 | -96,025 | |
| 0.19444 % | CornerCap Investment Counsel, Inc. | 108,424 | 0 | |
| 0.19246 % | Barclays Bank PLC | 107,317 | -310,448 | |
| 0.17353 % | BlackRock Financial Management, Inc. | 96,764 | 0 | |
| 0.13710 % | Two Sigma Investments, LP | 76,451 | -122,844 | |
| 0.11362 % | Forefront Analytics, LLC | 63,356 | -3,482 | |
| 0.11147 % | Arete Wealth Advisors, LLC | 62,156 | 4,966 | |
| 0.10717 % | Northern Trust Investments, Inc. | 59,762 | 0 | |
| 0.10287 % | Franklin Advisers, Inc. | 57,360 | 0 | |
| 0.09854 % | QS Investors, LLC | 54,947 | 0 | |
| 0.09626 % | Nogelo (Liisa I) | 53,677 | -26,325 | |
| 0.09367 % | Ergoteles Capital | 52,234 | 52,234 | |
| 0.08934 % | Susquehanna International Group, LLP | 49,815 | 25,903 | |
| 0.08825 % | Palombella (Vito J) | 49,212 | -4,463 | |
| 0.08151 % | Sigal (Charles Elliott) | 45,453 | 0 | |
| 0.07874 % | Ross Robert W | 43,906 | -10,594 | |
| 0.07532 % | Eagle Rock Investment Company, LLC | 42,000 | 20,000 | |
| 0.07173 % | Credit Suisse Asset Management | 40,000 | 0 | |
| 0.06970 % | Numeric Investors LLC | 38,864 | 25,464 | |
| 0.06806 % | International Assets Investment Management, LLC | 37,950 | 3,150 | |
| 0.06241 % | Adams (Chandra) | 34,800 | 34,800 | |
| 0.05922 % | Dimensional Fund Advisors, Ltd. | 33,023 | 0 | |
| 0.05797 % | Rath (Henry C) | 32,324 | -5,676 | |
| 0.05629 % | Morgan Stanley Smith Barney LLC | 31,386 | -12,041 | |
| 0.04827 % | Emerge Canada Inc | 26,916 | -3,376 | |
| 0.04744 % | KeyBanc Capital Markets | 26,455 | 0 | |
| 0.04614 % | O'Neill (Alison) | 25,728 | -4,463 | |
| 0.04385 % | BofA Global Research (US) | 24,451 | -39,375 | |
| 0.04169 % | Group One Trading, L.P. | 23,245 | -13,374 | |
| 0.04089 % | RBC Dominion Securities, Inc. | 22,800 | -100,540 | |
| 0.03138 % | Beddow Capital Management Inc. | 17,500 | 5,000 | |
| 0.03107 % | Private Advisor Group LLC | 17,325 | 0 | |
| 0.02937 % | Morgan Stanley & Co. LLC | 16,377 | -18,062 | |
| 0.02816 % | Commonwealth Financial Network | 15,700 | 15,700 | |
| 0.02376 % | Moloney Securities Asset Management, LLC | 13,250 | 13,250 | |
| 0.02291 % | Formidable Asset Management, LLC | 12,775 | 1,100 | |
| 0.02180 % | Advisor Group, Inc | 12,155 | 0 | |
| 0.02009 % | PGIM Quantitative Solutions LLC | 11,200 | 11,200 | |
| 0.01980 % | BNY Mellon Asset Management | 11,043 | 0 | |
| 0.01973 % | Platform Technology Partners LLC | 11,000 | 0 | |
| 0.01973 % | Consilium Associates | 11,000 | 0 | |
| 0.01925 % | Oppenheimer Asset Management Inc. | 10,733 | 0 | |
| 0.01491 % | UBS Financial Services, Inc. | 8,313 | -53,814 | |
| 0.01445 % | BlackRock Investment Management, LLC | 8,059 | 1,070 | |
| 0.01445 % | Lord, Abbett & Co. LLC | 8,059 | 0 | |
| 0.00812 % | Welzia Management SGIIC S.A. | 4,530 | 4,530 | |
| 0.00770 % | Tower Research Capital LLC | 4,291 | -33,009 | |
| 0.00763 % | Amalgamated Financial Corp. | 4,256 | 4,256 | |
| 0.00702 % | Simplex Trading, LLC | 3,916 | -15 | |
| 0.00511 % | Belvedere Trading, LLC | 2,851 | 2,851 | |
| 0.00497 % | Federated Hermes MDTA LLC | 2,774 | 1,622 | |
| 0.00400 % | Principal Funds, Inc. | 2,229 | -881 | |
| 0.00349 % | Mackenzie Financial Corporation | 1,946 | -253 | |
| 0.00320 % | C. M. Bidwell & Associates, Ltd. | 1,785 | 1,040 | |
| 0.00284 % | Independent Financial Partners | 1,585 | 0 | |
| 0.00263 % | BNP Paribas Securities Corp. North America | 1,468 | 996 | |
| 0.00252 % | J.P. Morgan Securities plc | 1,407 | -2,351 | |
| 0.00239 % | Westfield Capital Management Company, L.P. | 1,332 | 0 | |
| 0.00226 % | GF Fund Management Co., Ltd. | 1,262 | 512 | |
| 0.00215 % | Antonetti Capital Management, LLC | 1,200 | 0 | |
| 0.00135 % | Larson Financial Group LLC | 751 | 0 | |
| 0.00110 % | Money Concepts Capital Corp | 613 | -45,977 | |
| 0.00108 % | FMP Wealth Advisers | 600 | 100 | |
| 0.00087 % | RBC Capital Markets Wealth Management | 485 | 485 | |
| 0.00082 % | Tinkoff Capital OOO | 455 | 7 | |
| 0.00073 % | Newbridge Capital Management | 405 | 0 | |
| 0.00072 % | Wells Fargo Advisors | 400 | 0 | |