| 7.37190 % | RTW Investments L.P. | 3,111,680 | -204,352 | |
| 7.37041 % | BlackRock Institutional Trust Company, N.A. | 3,111,048 | 281,380 | |
| 7.05070 % | Paradigm BioCapital Advisors LP | 2,976,099 | 365,902 | |
| 5.84695 % | Jennison Associates LLC | 2,467,998 | -24,642 | |
| 5.81568 % | Tang Capital Management, LLC | 2,454,797 | 0 | |
| 5.57441 % | Deep Track Capital LP | 2,352,960 | 602,960 | |
| 5.42479 % | The Vanguard Group, Inc. | 2,289,805 | 69,637 | |
| 4.31823 % | Morgan Stanley & Co. LLC | 1,822,725 | 79,491 | |
| 4.28085 % | Janus Henderson Investors | 1,806,947 | 1,293,987 | |
| 3.31089 % | Frazier Life Sciences Management, L.P. | 1,397,527 | 0 | |
| 2.37376 % | TD Securities, Inc. | 1,001,962 | -872,783 | |
| 2.36339 % | Assenagon Asset Management S.A. | 997,587 | -127,718 | |
| 2.35827 % | Lord, Abbett & Co. LLC | 995,425 | -336,276 | |
| 2.32378 % | State Street Global Advisors (US) | 980,868 | 70,152 | |
| 2.24793 % | Macquarie Investment Management | 948,850 | 56,069 | |
| 2.21374 % | Geode Capital Management, L.L.C. | 934,420 | 68,986 | |
| 2.07946 % | Azamian (Bobak R) | 877,741 | 21,179 | |
| 2.07663 % | Driehaus Capital Management, LLC | 876,547 | 158,694 | |
| 1.80015 % | Invesco Advisers, Inc. | 759,842 | 111,689 | |
| 1.71330 % | D. E. Shaw & Co., L.P. | 723,183 | 312,507 | |
| 1.53700 % | Medical Strategy GmbH | 648,767 | -70,593 | |
| 1.28643 % | Adage Capital Management, L.P. | 543,000 | 33,000 | |
| 1.27767 % | Artisan Partners Limited Partnership | 539,303 | -63,911 | |
| 1.15449 % | Ensign Peak Advisors, Inc. | 487,310 | 0 | |
| 1.11669 % | Norges Bank Investment Management (NBIM) | 471,354 | 471,354 | |
| 1.08845 % | Qube Research & Technologies Ltd | 459,436 | 212,592 | |
| 1.05307 % | ClearBridge Investments, LLC | 444,502 | 444,502 | |
| 0.96173 % | BofA Global Research (US) | 405,947 | 6,070 | |
| 0.92772 % | BlackRock Financial Management, Inc. | 391,589 | 290,492 | |
| 0.88545 % | Rock Springs Capital Management LP | 373,750 | 19,374 | |
| 0.86367 % | J. Goldman & Co., L.P. | 364,557 | 224,269 | |
| 0.86003 % | Goldman Sachs & Company, Inc. | 363,017 | 96,625 | |
| 0.83280 % | T. Rowe Price Associates, Inc. | 351,525 | -52,319 | |
| 0.80904 % | MPM BioImpact LLC | 341,496 | 341,496 | |
| 0.78014 % | Charles Schwab Investment Management, Inc. | 329,297 | 38,979 | |
| 0.77165 % | Nuveen LLC | 325,712 | 72,228 | |
| 0.76804 % | Northern Trust Investments, Inc. | 324,189 | -9,499 | |
| 0.71073 % | Cormorant Asset Management, LP | 300,000 | -100,000 | |
| 0.59228 % | Polygon Management Ltd. | 250,000 | 71,530 | |
| 0.57356 % | Capitolis Liquid Global Markets LLC | 242,100 | 242,100 | |
| 0.56176 % | Jump Financial, LLC | 237,117 | 188,317 | |
| 0.54311 % | Citadel Advisors LLC | 229,246 | -763,396 | |
| 0.48567 % | Cutter Capital Management, LP | 205,000 | 92,500 | |
| 0.47382 % | Integral Health Asset Management, LLC | 200,000 | 0 | |
| 0.46885 % | OrbiMed Advisors, LLC | 197,900 | -455,843 | |
| 0.46561 % | Ikarian Capital LLC | 196,536 | -288,485 | |
| 0.44018 % | RBC Dominion Securities, Inc. | 185,800 | 185,800 | |
| 0.42856 % | Link (William J) | 180,894 | 3,350 | |
| 0.42089 % | Tri Locum Partners LP | 177,656 | 177,656 | |
| 0.41459 % | PGIM Securities Investment Trust Enterprise | 175,000 | 57,000 | |
| 0.40275 % | Sands Capital Ventures LLC | 170,000 | 0 | |
| 0.38615 % | Jefferies LLC | 162,996 | 84,188 | |
| 0.37310 % | Invesco Capital Management LLC | 157,487 | -20,883 | |
| 0.36084 % | BNP Paribas Securities Corp. North America | 152,309 | 76,601 | |
| 0.34607 % | Morgan Stanley Investment Management Inc. (US) | 146,077 | -37,991 | |
| 0.34409 % | Russell Investments Trust Company | 145,240 | 10,623 | |
| 0.32698 % | Balyasny Asset Management LP | 138,019 | 78,345 | |
| 0.32588 % | BlackRock Investment Management, LLC | 137,553 | 42,401 | |
| 0.31504 % | Mutual of America Capital Management LLC | 132,978 | 2,689 | |
| 0.31405 % | Allspring Global Investments, LLC | 132,562 | -36,159 | |
| 0.29715 % | Barclays Bank PLC | 125,426 | 72,597 | |
| 0.29291 % | Wellington Management Company, LLP | 123,636 | 7,526 | |
| 0.28709 % | Ally Bridge Group NY LLC | 121,182 | -6,750 | |
| 0.25289 % | J.P. Morgan Securities LLC | 106,743 | 97,540 | |
| 0.24897 % | First Trust Advisors L.P. | 105,090 | -1,767 | |
| 0.24317 % | Squarepoint Capital LLP | 102,642 | 44,986 | |
| 0.24054 % | DWS Investments UK Limited | 101,532 | -49,123 | |
| 0.23726 % | Woodline Partners LP | 100,149 | 0 | |
| 0.22417 % | Trexquant Investment LP | 94,624 | 94,624 | |
| 0.21828 % | Dimensional Fund Advisors, L.P. | 92,134 | -216,096 | |
| 0.19005 % | Pictet Asset Management Ltd. | 80,220 | -4,477 | |
| 0.18918 % | Commonwealth Financial Network | 79,851 | 8,259 | |
| 0.18878 % | Neervannan (Seshadri) | 79,682 | 14,915 | |
| 0.18281 % | Gilder Gagnon Howe & Co. LLC | 77,164 | -339,647 | |
| 0.17929 % | BNY Mellon Asset Management | 75,680 | 4,999 | |
| 0.17893 % | Lisanti Capital Growth, LLC | 75,525 | 5,345 | |
| 0.17038 % | Wells Fargo Advisors | 71,918 | 29,861 | |
| 0.17033 % | Baird Investment Management | 71,895 | -20,802 | |
| 0.15052 % | Schweizerische Nationalbank | 63,533 | 8,000 | |
| 0.14932 % | PDT Partners, LLC | 63,026 | 63,026 | |
| 0.14744 % | Victory Capital Management Inc. | 62,235 | 17,915 | |
| 0.14613 % | Robert W. Baird & Co. Inc. | 61,681 | -49,111 | |
| 0.14593 % | abrdn Inc. | 61,597 | 9,728 | |
| 0.14415 % | Parametric Portfolio Associates LLC | 60,846 | -4,417 | |
| 0.14332 % | Connor, Clark & Lunn Investment Management Ltd. | 60,495 | 60,495 | |
| 0.14325 % | BlackRock Advisors (UK) Limited | 60,467 | 4,073 | |
| 0.14294 % | Managed Account Advisors LLC | 60,333 | 31,066 | |
| 0.13886 % | Voloridge Investment Management, LLC | 58,613 | 58,613 | |
| 0.13774 % | Millennium Management LLC | 58,141 | -189,054 | |
| 0.13658 % | Rhumbline Advisers Ltd. Partnership | 57,650 | 5,968 | |
| 0.13038 % | Wells Fargo Bank, N.A. | 55,035 | 37,249 | |
| 0.12942 % | Federated MDTA LLC | 54,627 | 258 | |
| 0.12790 % | UBS Asset Management (Switzerland) | 53,987 | 25,995 | |
| 0.12691 % | AQR Capital Management, LLC | 53,568 | 37,344 | |
| 0.12563 % | Manulife Investment Management (North America) Limited | 53,028 | -2,809 | |
| 0.12398 % | Susquehanna International Group, LLP | 52,334 | -8,523 | |
| 0.12261 % | Universal-Investment-Gesellschaft mbH | 51,752 | 16,359 | |
| 0.12130 % | BlackRock Asset Management Ireland Limited | 51,199 | 2,284 | |
| 0.11631 % | Wahl (Bryan) | 49,095 | 9,527 | |
| 0.11444 % | BlackRock Investment Management (UK) Ltd. | 48,305 | 19,503 | |