| 11.28824 % | OrbiMed Advisors, LLC | 6,059,528 | 0 | |
| 8.57298 % | Rubric Capital Management LP | 4,601,977 | -173,023 | |
| 6.59681 % | Luther King Capital Management Corp. | 3,541,170 | 420,000 | |
| 5.48609 % | Lytton (Laurence W) | 2,944,932 | 1,119,698 | |
| 5.40288 % | AIGH Capital Management, LLC. | 2,900,267 | -194,917 | |
| 5.33530 % | Lundbeckfond Invest | 2,863,987 | 2,863,987 | |
| 3.70439 % | BlackRock Institutional Trust Company, N.A. | 1,988,518 | -164,715 | |
| 3.41961 % | The Vanguard Group, Inc. | 1,835,649 | -157,111 | |
| 3.09689 % | Morgan Stanley & Co. LLC | 1,662,410 | 13,115 | |
| 2.74316 % | Rice Hall James & Associates, LLC | 1,472,527 | 74,470 | |
| 2.23667 % | 5AM Ventures | 1,200,647 | 0 | |
| 1.93119 % | Thrivent Asset Management, LLC | 1,036,665 | -12,273 | |
| 1.85439 % | Nantahala Capital Management, LLC | 995,438 | 0 | |
| 1.80189 % | Worth Venture Partners, LLC | 967,256 | -33,927 | |
| 1.70952 % | Velan Capital Investment Management LP | 917,668 | 0 | |
| 1.59333 % | UBS Financial Services, Inc. | 855,302 | 527,887 | |
| 1.49964 % | State Street Global Advisors (US) | 805,009 | 71,267 | |
| 1.40089 % | Apis Capital Advisors LLC | 752,000 | 247,053 | |
| 1.39621 % | Geode Capital Management, L.L.C. | 749,484 | -57,996 | |
| 1.22897 % | Kingdon Capital Management, L.L.C. | 659,711 | -340,289 | |
| 1.00311 % | Millennium Management LLC | 538,470 | 454,080 | |
| 0.93145 % | RBC Dominion Securities, Inc. | 500,000 | 500,000 | |
| 0.93145 % | Perceptive Advisors LLC | 500,000 | 0 | |
| 0.92722 % | Tejara Capital Ltd. | 497,730 | -164,322 | |
| 0.51646 % | Northern Trust Investments, Inc. | 277,237 | -34,402 | |
| 0.46379 % | Parametric Portfolio Associates LLC | 248,965 | 211,332 | |
| 0.44059 % | Morgan Stanley Smith Barney LLC | 236,511 | 37,298 | |
| 0.40541 % | Diadema Partners LP | 217,623 | 217,623 | |
| 0.25794 % | Susquehanna International Group, LLP | 138,460 | 64,551 | |
| 0.24232 % | Citadel Advisors LLC | 130,075 | 91,412 | |
| 0.22792 % | Tucker (John H) | 122,345 | -154,943 | |
| 0.22634 % | J. Goldman & Co., L.P. | 121,500 | -464,735 | |
| 0.20846 % | Schaeffer (Leonard D) | 111,900 | 0 | |
| 0.20417 % | BlackRock Investment Management, LLC | 109,596 | 14,338 | |
| 0.17662 % | Charles Schwab Investment Management, Inc. | 94,809 | -11,126 | |
| 0.16946 % | Balanced Rock Investment Advisors LLC | 90,968 | 19,768 | |
| 0.15601 % | BlackRock Financial Management, Inc. | 83,748 | -1,397 | |
| 0.14186 % | Nuveen LLC | 76,151 | -14,352 | |
| 0.12913 % | Raymond James & Associates, Inc. | 69,318 | -600 | |
| 0.12649 % | Bridgeway Capital Management, LLC | 67,900 | 0 | |
| 0.12308 % | Nomura Securities Co., Ltd. | 66,072 | 66,072 | |
| 0.11835 % | Barclays Bank PLC | 63,529 | 16,916 | |
| 0.11744 % | BNY Mellon Asset Management | 63,040 | 4,990 | |
| 0.11615 % | Goldman Sachs & Company, Inc. | 62,351 | -9,121 | |
| 0.10642 % | Pale Fire Capital SE | 57,128 | 57,128 | |
| 0.10153 % | Rhumbline Advisers Ltd. Partnership | 54,500 | 3,001 | |
| 0.09334 % | Persistent Asset Partners Limited | 50,107 | 50,107 | |
| 0.08396 % | Commonwealth Financial Network | 45,071 | 5,300 | |
| 0.08149 % | CAPTRUST Financial Advisors | 43,746 | 3,621 | |
| 0.07576 % | HRT Financial LP | 40,667 | 40,667 | |
| 0.07365 % | Goldman Sachs Asset Management, L.P. | 39,537 | -9,888 | |
| 0.07202 % | Comerica, Inc. | 38,662 | 0 | |
| 0.06986 % | TNB Financial Services, Inc. | 37,500 | 0 | |
| 0.06812 % | WealthEdge Investment Advisors, LLC | 36,569 | -28,478 | |
| 0.06512 % | BlackRock Advisors (UK) Limited | 34,958 | 5,504 | |
| 0.05916 % | XTX Markets LLC | 31,756 | 31,756 | |
| 0.05909 % | BofA Global Research (US) | 31,721 | -4,474 | |
| 0.05661 % | Nokes (Rachael) | 30,386 | -75,060 | |
| 0.05487 % | BlackRock Asset Management Ireland Limited | 29,454 | 6,278 | |
| 0.05443 % | Simplex Trading, LLC | 29,217 | 29,217 | |
| 0.05341 % | Los Angeles Capital Management LLC | 28,670 | 28,670 | |
| 0.05123 % | Lido Advisors, LLC | 27,500 | 3,500 | |
| 0.04323 % | Jane Street Capital, L.L.C. | 23,208 | 23,208 | |
| 0.03973 % | MetLife Investment Management, LLC | 21,326 | 21,326 | |
| 0.03914 % | AllianceBernstein L.P. | 21,010 | 5,800 | |
| 0.03905 % | Group One Trading, L.P. | 20,962 | -54,512 | |
| 0.03866 % | Mirae Asset Global Investments (USA) LLC | 20,751 | -3,910 | |
| 0.03620 % | T. Rowe Price International Ltd | 19,431 | 4,288 | |
| 0.03595 % | Corebridge Financial Inc. | 19,300 | -286 | |
| 0.03470 % | DWS Investments UK Limited | 18,628 | -12,302 | |
| 0.03436 % | Virtu Americas LLC | 18,445 | 18,445 | |
| 0.03431 % | Mellon Investments Corporation | 18,418 | 2,881 | |
| 0.03296 % | Wells Fargo Bank, N.A. | 17,692 | -1,131 | |
| 0.03230 % | INTECH Investment Management LLC | 17,339 | -12,972 | |
| 0.03149 % | Vanguard Personalized Indexing Management, LLC | 16,903 | 16,903 | |
| 0.03014 % | JPMorgan Private Bank (United States) | 16,177 | -2,453 | |
| 0.02714 % | Legato Capital Management LLC | 14,568 | -707 | |
| 0.02701 % | Chicago Partners Wealth Advisors | 14,498 | 1,770 | |
| 0.02557 % | Fidelity Management & Research Company LLC | 13,727 | 12,022 | |
| 0.02515 % | Perkins Capital Management, Inc. | 13,500 | -3,700 | |
| 0.02501 % | Invesco Advisers, Inc. | 13,426 | -441 | |
| 0.02484 % | Citi Investment Research (US) | 13,335 | -15,500 | |
| 0.02407 % | Focus Partners Wealth, LLC | 12,923 | 12,923 | |
| 0.02398 % | Metropolitan Life Insurance Co. (US) | 12,874 | 12,874 | |
| 0.02320 % | Invesco Capital Management LLC | 12,453 | -2,382 | |
| 0.02150 % | New York State Common Retirement Fund | 11,543 | 0 | |
| 0.02142 % | Andbank Wealth Management, SGIIC, S.A.U. | 11,500 | 3,000 | |
| 0.02102 % | Walleye Capital LLC | 11,284 | 11,284 | |
| 0.02041 % | Voya Investment Management LLC | 10,954 | 10,954 | |
| 0.02011 % | Bay Colony Advisors | 10,795 | 10,795 | |
| 0.01954 % | AQR Capital Management, LLC | 10,491 | 10,491 | |
| 0.01870 % | China Universal Asset Management Co., Ltd. | 10,037 | -573 | |
| 0.01866 % | Moss Adams Wealth Advisors LLC | 10,016 | 10,016 | |
| 0.01739 % | Police and Firemen's Retirement System of New Jersey | 9,336 | 3,628 | |
| 0.01737 % | Tower Research Capital LLC | 9,324 | 5,473 | |
| 0.01099 % | Northern Trust Global Investments | 5,901 | 0 | |
| 0.01048 % | Osaic Holdings, Inc. | 5,628 | 0 | |
| 0.00961 % | Raymond James Financial Services Advisors, Inc. | 5,159 | 0 | |
| 0.00840 % | Principal Global Investors (Equity) | 4,511 | -1,078 | |
| 0.00719 % | Legal & General Investment Management Ltd. | 3,861 | -564 | |