43.45359 % | Third Security, LLC | 116,337,175 | -507,182 | 3/31/2025 |
7.71201 % | Merck Serono SA | 20,647,152 | 0 | 3/31/2025 |
6.07661 % | Patient Capital Management, LLC | 16,268,741 | -1,103,560 | 6/30/2025 |
4.21175 % | Adage Capital Management, L.P. | 11,276,000 | 0 | 6/30/2025 |
3.67183 % | BlackRock Institutional Trust Company, N.A. | 9,830,493 | 271,445 | 6/30/2025 |
3.38779 % | The Vanguard Group, Inc. | 9,070,029 | 274,070 | 6/30/2025 |
1.59814 % | Iridian Asset Management LLC | 4,278,662 | -307,147 | 6/30/2025 |
1.40037 % | Geode Capital Management, L.L.C. | 3,749,182 | 269,580 | 6/30/2025 |
1.23895 % | Sabzevari (Helen) | 3,317,022 | 557,913 | 5/16/2025 |
1.13141 % | State Street Global Advisors (US) | 3,029,100 | -9,027 | 6/30/2025 |
0.57627 % | Parkman Healthcare Partners LLC | 1,542,823 | -1,648,520 | 6/30/2025 |
0.53729 % | Schonfeld Strategic Advisors LLC | 1,438,463 | -1,355,786 | 6/30/2025 |
0.52240 % | Morgan Stanley & Co. LLC | 1,398,621 | 1,019,976 | 6/30/2025 |
0.51591 % | Northern Trust Investments, Inc. | 1,381,242 | 277,803 | 6/30/2025 |
0.47462 % | Charles Schwab Investment Management, Inc. | 1,270,698 | 53,934 | 6/30/2025 |
0.43083 % | Hassan (Fred) | 1,153,452 | 123,618 | 3/31/2025 |
0.42592 % | Frank (Steven R) | 1,140,307 | 116,147 | 3/31/2025 |
0.42569 % | Susquehanna International Group, LLP | 1,139,702 | 975,244 | 6/30/2025 |
0.31086 % | BofA Global Research (US) | 832,261 | 599,914 | 6/30/2025 |
0.27756 % | Perez Jeffrey Thomas | 743,097 | 0 | 3/31/2025 |
0.26695 % | Corient Private Wealth LLC | 714,691 | 0 | 6/30/2025 |
0.25894 % | Alvarez (Cesar Licinio) | 693,264 | 123,331 | 3/31/2025 |
0.25698 % | JPMorgan Asset Management U.K. Limited | 687,995 | -39,187 | 6/30/2025 |
0.25461 % | Lehr Donald P | 681,649 | 110,367 | 5/16/2025 |
0.25120 % | Lexaurum Advisors, LLC | 672,543 | -12,755 | 6/30/2025 |
0.24982 % | GMT Capital Corp. | 668,830 | 0 | 6/30/2025 |
0.23467 % | Morgan Stanley Smith Barney LLC | 628,280 | -105 | 6/30/2025 |
0.22253 % | Turley (James S) | 595,772 | 123,331 | 3/31/2025 |
0.21635 % | Gupta (Vinita D) | 579,240 | 123,618 | 3/31/2025 |
0.19439 % | Kindler (Jeffrey B) | 520,430 | 127,067 | 3/31/2025 |
0.19403 % | EMFO, LLC | 519,475 | 0 | 6/30/2024 |
0.18137 % | Nuveen LLC | 485,572 | -39,456 | 6/30/2025 |
0.18003 % | BlackRock Investment Management, LLC | 482,001 | 68,238 | 6/30/2025 |
0.17085 % | Thomasian (Harry Jr.) | 457,410 | 103,034 | 5/16/2025 |
0.15088 % | Shah (Rutul R.) | 403,959 | 116,364 | 5/16/2025 |
0.13788 % | Marshall Wace LLP | 369,138 | 369,138 | 6/30/2025 |
0.13606 % | RBC Dominion Securities, Inc. | 364,259 | 363,709 | 6/30/2025 |
0.13574 % | CIBC Private Wealth Management | 363,404 | 31,928 | 6/30/2025 |
0.13213 % | Aperio Group, LLC | 353,738 | 83,782 | 6/30/2025 |
0.12767 % | Fore Capital, LLC | 341,811 | -50,000 | 6/30/2025 |
0.12515 % | Diametric Capital | 335,057 | 335,057 | 6/30/2025 |
0.12484 % | Fidelity Management & Research Company LLC | 334,241 | 17,100 | 6/30/2025 |
0.12232 % | Goldman Sachs & Company, Inc. | 327,489 | 100,733 | 6/30/2025 |
0.12081 % | BlackRock Financial Management, Inc. | 323,450 | -27,630 | 6/30/2025 |
0.12064 % | UBS Financial Services, Inc. | 322,994 | -189,312 | 6/30/2025 |
0.11758 % | Citadel Advisors LLC | 314,804 | 314,804 | 6/30/2025 |
0.11445 % | Barclays Bank PLC | 306,418 | 126,583 | 6/30/2025 |
0.10735 % | Renaissance Technologies LLC | 287,403 | -505,400 | 6/30/2025 |
0.10304 % | Inspire Investing | 275,870 | 40,758 | 6/30/2025 |
0.10065 % | Cetera Investment Advisers LLC | 269,462 | -14,600 | 6/30/2025 |
0.09525 % | Mill Creek Capital Advisors, LLC | 255,000 | 0 | 6/30/2025 |
0.09320 % | Jane Street Capital, L.L.C. | 249,531 | 249,531 | 6/30/2025 |
0.09074 % | AllianceBernstein L.P. | 242,940 | 16,280 | 6/30/2025 |
0.08918 % | Millennium Management LLC | 238,752 | 210,716 | 6/30/2025 |
0.08835 % | BNY Mellon Asset Management | 236,539 | 27,629 | 6/30/2025 |
0.07426 % | Hightower Advisors, LLC | 198,822 | 6,970 | 6/30/2025 |
0.07398 % | Rhumbline Advisers Ltd. Partnership | 198,078 | 7,041 | 6/30/2025 |
0.07229 % | Osaic Holdings, Inc. | 193,527 | -966 | 6/30/2025 |
0.06960 % | Group One Trading, L.P. | 186,347 | 186,347 | 6/30/2025 |
0.06829 % | GSA Capital Partners LLP | 182,826 | 182,826 | 6/30/2025 |
0.06643 % | Goldman Sachs Asset Management, L.P. | 177,859 | 71,103 | 6/30/2025 |
0.06605 % | Agee (Nancy Howell) | 176,836 | 126,760 | 7/5/2025 |
0.06433 % | BlackRock Advisors (UK) Limited | 172,234 | 26,725 | 7/31/2025 |
0.06209 % | Cambridge Investment Research Advisors, Inc. | 166,229 | -25,490 | 6/30/2025 |
0.05435 % | BlackRock Asset Management Ireland Limited | 145,509 | -2,549 | 6/30/2025 |
0.05088 % | Simplex Trading, LLC | 136,232 | 105,814 | 6/30/2025 |
0.05000 % | XTX Markets LLC | 133,860 | 133,860 | 6/30/2025 |
0.04896 % | Prelude Capital Management, LLC | 131,090 | 131,090 | 6/30/2025 |
0.04395 % | AQR Capital Management, LLC | 117,666 | 54,487 | 6/30/2025 |
0.03757 % | Assenagon Asset Management S.A. | 100,576 | 305 | 7/31/2025 |
0.03522 % | Creative Planning, Inc. | 94,291 | 52,901 | 6/30/2025 |
0.03508 % | Two Sigma Investments, LP | 93,913 | 12,213 | 6/30/2025 |
0.03492 % | Mirae Asset Global Investments (USA) LLC | 93,488 | 2,078 | 6/30/2025 |
0.03393 % | Mellon Investments Corporation | 90,831 | -32,201 | 6/30/2025 |
0.03272 % | Cary Street Partners Financial LLC | 87,593 | 0 | 6/30/2025 |
0.03116 % | MetLife Investment Management, LLC | 83,422 | 241 | 6/30/2025 |
0.03058 % | Wells Fargo Advisors | 81,879 | 15,000 | 6/30/2025 |
0.02941 % | Wells Fargo Bank, N.A. | 78,750 | -827 | 6/30/2025 |
0.02933 % | SG Americas Securities, L.L.C. | 78,521 | 33,173 | 6/30/2025 |
0.02741 % | PGIM Quantitative Solutions LLC | 73,385 | -76,801 | 6/30/2025 |
0.02669 % | Tudor Investment Corporation | 71,464 | 0 | 6/30/2025 |
0.02648 % | JPMorgan Private Bank (United States) | 70,893 | 7,168 | 6/30/2025 |
0.02622 % | DWS Investments UK Limited | 70,188 | -20,843 | 6/30/2025 |
0.02611 % | INTECH Investment Management LLC | 69,903 | -48,006 | 6/30/2025 |
0.02572 % | T. Rowe Price International Ltd | 68,866 | 8,600 | 6/30/2025 |
0.02565 % | StoneRidge Investment Partners, LLC | 68,681 | 0 | 6/30/2025 |
0.02469 % | American Financial Group, Inc. | 66,114 | 0 | 6/30/2025 |
0.02466 % | Corebridge Financial Inc. | 66,015 | -979 | 3/31/2025 |
0.02271 % | Manulife Investment Management (North America) Limited | 60,788 | 4,508 | 6/30/2025 |
0.02220 % | Graham Capital Management, L.P. | 59,425 | 48,116 | 6/30/2025 |
0.02205 % | Tennant (Phil) | 59,031 | 43,472 | 5/16/2025 |
0.02203 % | Citi Investment Research (US) | 58,991 | -38,881 | 6/30/2025 |
0.02194 % | China Universal Asset Management Co., Ltd. | 58,744 | -3,355 | 3/31/2025 |
0.02104 % | Stifel, Nicolaus & Company, Incorporated | 56,332 | -1,125 | 6/30/2025 |
0.02100 % | Vaughan Nelson Investment Management, L.P. | 56,210 | 0 | 3/31/2025 |
0.02060 % | Commonwealth Financial Network | 55,160 | 0 | 6/30/2025 |
0.02054 % | PGIM Fixed Income | 55,000 | 0 | 6/30/2025 |
0.02022 % | Allegheny Financial Group Ltd. | 54,130 | 0 | 6/30/2025 |
0.01870 % | Metropolitan Life Insurance Co. (US) | 50,074 | 0 | 6/30/2025 |
0.01833 % | Synovus Securities, Inc. | 49,065 | 0 | 6/30/2025 |