| 13.38890 % | Briarwood Chase Management LLC | 13,851,927 | 1,112,099 | |
| 11.64605 % | Novo Holdings A/S | 12,048,802 | 0 | |
| 11.12572 % | Institut Merieux SA | 11,510,481 | 0 | |
| 8.16502 % | Vulpes Investment Management Private Limited | 8,447,390 | 5,250 | |
| 5.67654 % | M&G Investment Management Ltd. | 5,872,847 | 548,412 | |
| 4.70371 % | Liontrust Investment Partners LLP | 4,866,374 | 0 | |
| 3.70679 % | Columbia Threadneedle Investments (UK) | 3,834,977 | -282,768 | |
| 3.35907 % | Hargreaves Lansdown Asset Management Limited | 3,475,237 | -115,485 | |
| 3.26987 % | Serum Life Sciences Ltd | 3,382,950 | 0 | |
| 2.90413 % | Vitruvian Partners LLP | 3,004,567 | 0 | |
| 0.52201 % | abrdn Inc. | 540,059 | 0 | |
| 0.48189 % | Vanguard Global Advisers LLC | 498,555 | 53,730 | |
| 0.42414 % | Doliveux (Roch Frederic) | 438,805 | 67,000 | |
| 0.38387 % | Lombard Odier Asset Management (Europe) Ltd | 397,145 | -167,973 | |
| 0.31096 % | Legal & General Investment Management Ltd. | 321,713 | -132,000 | |
| 0.30712 % | Platinum Asset Management | 317,738 | 191,049 | |
| 0.29964 % | Royce Investment Partners | 310,000 | 0 | |
| 0.27064 % | Freeman (Robert M) | 280,000 | 5,000 | |
| 0.25999 % | Acadian Asset Management LLC | 268,980 | -400,643 | |
| 0.25232 % | Oaktree Capital Management, L.P. | 261,043 | -188,957 | |
| 0.24284 % | Dawson (John) | 251,241 | 0 | |
| 0.20298 % | Sir A M D & Lady E V Gormley | 210,000 | -30,000 | |
| 0.18011 % | TrinityBridge | 186,337 | 0 | |
| 0.17955 % | Pine (Elliot) | 185,755 | 83,728 | |
| 0.16243 % | Crawford (Ward) | 168,044 | 6,044 | |
| 0.15437 % | abrdn Alternative Investments Limited | 159,705 | 0 | |
| 0.15437 % | BlackRock Advisors (UK) Limited | 159,705 | 0 | |
| 0.15123 % | Watts (T) | 156,459 | -21,203 | |
| 0.14652 % | BlackRock Life, Ltd. | 151,592 | -107,506 | |
| 0.14325 % | Mitrophanous (Kyriacos) | 148,200 | 0 | |
| 0.13365 % | Bellecapital AG | 138,275 | 0 | |
| 0.13365 % | DZ PRIVATBANK S.A. | 138,275 | 0 | |
| 0.13165 % | Birtles (Russell) | 136,200 | 69,440 | |
| 0.12807 % | LGT Bank (Schweiz) AG | 132,500 | 0 | |
| 0.12074 % | Fidelity International | 124,916 | 3,140 | |
| 0.11696 % | EFG Bank SA | 121,000 | 0 | |
| 0.11650 % | Berry (Alexander) | 120,529 | -50,000 | |
| 0.11275 % | Kilbey (Graham) | 116,647 | 19,574 | |
| 0.10643 % | River Global Investors LLP | 110,113 | -92,600 | |
| 0.09666 % | Lauxera Capital Partners | 100,000 | 0 | |
| 0.09150 % | JPMorgan Asset Management U.K. Limited | 94,667 | -2,657 | |
| 0.08747 % | Charnock (Colin) | 90,497 | 2,997 | |
| 0.06930 % | Batchelor (Jeffery Tudor) | 71,698 | 0 | |
| 0.06838 % | HSBC Global Asset Management (UK) Limited | 70,749 | 70,749 | |
| 0.06403 % | Hopkins (Stephen Laurence) | 66,246 | 0 | |
| 0.06175 % | Margetts Fund Management Limited | 63,884 | 17,637 | |
| 0.05941 % | Page (Nicholas) | 61,463 | 1,046 | |
| 0.05812 % | Da'Silva (Carlos) | 60,129 | 0 | |
| 0.05799 % | Russell (Hilary Ann) | 60,000 | 60,000 | |
| 0.05315 % | Tallarigo (Lorenzo) | 54,988 | 0 | |
| 0.04837 % | Foster (Edward David) | 50,046 | 0 | |
| 0.04805 % | Pink (Daemon Joseph) | 49,711 | 3,744 | |
| 0.04786 % | Ostrum Asset Management | 49,510 | 49,510 | |
| 0.04777 % | DBS Bank Ltd. | 49,424 | -70,059 | |
| 0.04775 % | First Sentier Investors | 49,406 | 49,406 | |
| 0.04635 % | Hignett (Philip) | 47,950 | 0 | |
| 0.04491 % | Brompton Asset Management LLP | 46,458 | 0 | |
| 0.04361 % | Pass (M) | 45,114 | 0 | |
| 0.03944 % | AFH Wealth Management | 40,801 | 0 | |
| 0.03872 % | McKenzie (I) | 40,063 | 0 | |
| 0.03866 % | Slater (Jonathan) | 40,000 | 40,000 | |
| 0.03864 % | Hayden (Michael Reuben) | 39,973 | 0 | |
| 0.03820 % | St. Galler Kantonalbank AG | 39,516 | 0 | |
| 0.03803 % | Ninety One SA Pty Ltd. | 39,350 | -1,240 | |
| 0.03596 % | Gordon (Graeme John) | 37,200 | 37,200 | |
| 0.03540 % | Green (Duncan Christopher) | 36,628 | 19,848 | |
| 0.03532 % | McKay (James Patrick) | 36,546 | 0 | |
| 0.03383 % | Dr R F & Mrs A M Ker | 35,000 | 35,000 | |
| 0.03344 % | Da Silva (Carl) | 34,596 | 0 | |
| 0.03331 % | Cruickshank (N) | 34,462 | 0 | |
| 0.03286 % | Allspring Global Investments, LLC | 33,997 | 0 | |
| 0.03191 % | Rider (G) | 33,010 | 33,010 | |
| 0.03087 % | Calnan (Terence Arthur) | 31,942 | 0 | |
| 0.03068 % | Rose (William Marcus Henderson) | 31,746 | 0 | |
| 0.02932 % | Khan (Naheed) | 30,333 | 0 | |
| 0.02915 % | Abdul-Rahman (Ibrahim) | 30,153 | 0 | |
| 0.02900 % | Jhaver (Siddarth) | 30,000 | 30,000 | |
| 0.02885 % | Prescott (Ian Charles) | 29,850 | 0 | |
| 0.02869 % | Preston (Heather Elizabeth) | 29,687 | 11,389 | |
| 0.02814 % | Black (L) | 29,113 | 0 | |
| 0.02706 % | Birrell (Donald John) | 28,000 | 0 | |
| 0.02658 % | Holmes (L) | 27,500 | 7,500 | |
| 0.02599 % | Paton (Christopher) | 26,892 | 26,892 | |
| 0.02597 % | Johnson (Nicholas) | 26,866 | 26,866 | |
| 0.02568 % | Mc-Kay (James) | 26,571 | 0 | |
| 0.02561 % | Rodrigues (B) | 26,500 | 0 | |
| 0.02513 % | Garrett (John Mansell) | 26,000 | 26,000 | |
| 0.02444 % | Moukheibir (Catherine) | 25,287 | 0 | |
| 0.02416 % | Bamford (Andrew Paul) | 25,000 | 25,000 | |
| 0.02347 % | Maybury (Andrew Leighton) | 24,279 | 0 | |
| 0.02291 % | University of Massachusetts Medical School | 23,698 | 0 | |
| 0.02276 % | Toomey (J J) | 23,547 | 0 | |
| 0.02185 % | abrdn Investments Limited | 22,605 | -36,268 | |
| 0.02179 % | Brown (Rebecca Ann) | 22,540 | 0 | |
| 0.02161 % | Yogarajah (Sinnappah) | 22,358 | 0 | |
| 0.02126 % | Harris (E) | 21,993 | -20,000 | |
| 0.02109 % | Harvey (Richard) | 21,820 | 0 | |
| 0.02099 % | Glass (Clive) | 21,721 | 0 | |
| 0.02027 % | Chesworth (David) | 20,972 | 0 | |
| 0.01933 % | Nicholson (Alistair Jeffrey) | 20,000 | 0 | |