| 1.49384 % | Long Focus Capital Management LLC | 23,756,687 | 0 | |
| 1.41989 % | Two Seas Capital LP | 22,580,701 | 2,051,016 | |
| 0.69169 % | EcoR1 Capital, LLC | 11,000,000 | -16,404,070 | |
| 0.30244 % | MPM Capital Inc. | 4,809,677 | -526,038 | |
| 0.27742 % | MPM BioImpact LLC | 4,411,821 | -482,523 | |
| 0.26522 % | Morgan Stanley & Co. LLC | 4,217,865 | 1,589,753 | |
| 0.15616 % | Rock Springs Capital Management LP | 2,483,468 | 0 | |
| 0.12351 % | Acadian Asset Management LLC | 1,964,141 | -254,074 | |
| 0.11840 % | Renaissance Technologies LLC | 1,882,860 | 69,000 | |
| 0.07179 % | BofA Global Research (US) | 1,141,713 | -5,300 | |
| 0.05030 % | Alpha Architect, LLC | 800,000 | 800,000 | |
| 0.04732 % | Bellecapital AG | 752,458 | 0 | |
| 0.03843 % | Menzel (Garry E) | 611,224 | 401,293 | |
| 0.03144 % | B. Riley Wealth Advisors, Inc. | 500,000 | 500,000 | |
| 0.02919 % | Fidelity Management & Research Company LLC | 464,278 | -1,290,611 | |
| 0.02722 % | Rathbones Investment Management Limited | 432,818 | 0 | |
| 0.02683 % | State Street Investment Management (US) | 426,714 | 5,422 | |
| 0.02485 % | Rawcliffe Adrian | 395,227 | 219,591 | |
| 0.01251 % | Bertrand William C Jr | 198,892 | 59,860 | |
| 0.01075 % | Lunger (John) | 170,890 | 59,860 | |
| 0.00838 % | Norry (Elliot) | 133,265 | 66,406 | |
| 0.00698 % | Piccina (Cintia) | 111,073 | 94,236 | |
| 0.00694 % | Lakeridge Wealth Management LLC | 110,400 | 110,400 | |
| 0.00686 % | Almitas Capital LLC | 109,054 | 109,054 | |
| 0.00658 % | AllianceBernstein L.P. | 104,619 | 37,309 | |
| 0.00566 % | Osaic Holdings, Inc. | 90,058 | 25,000 | |
| 0.00563 % | BlackRock Financial Management, Inc. | 89,477 | 0 | |
| 0.00517 % | BlackRock Institutional Trust Company, N.A. | 82,187 | 0 | |
| 0.00503 % | XTX Markets LLC | 80,022 | 80,022 | |
| 0.00497 % | CAPTRUST Financial Advisors | 79,083 | -1,526 | |
| 0.00461 % | Tennessee Consolidated Retirement System | 73,376 | 0 | |
| 0.00422 % | Geode Capital Management, L.L.C. | 67,032 | -42,034 | |
| 0.00381 % | UBS Financial Services, Inc. | 60,552 | -952,188 | |
| 0.00345 % | SEI Investments Management Corporation | 54,824 | 0 | |
| 0.00344 % | New Jersey Division of Investment | 54,718 | 0 | |
| 0.00330 % | Régime de rentes du Mouvement Desjardins | 52,431 | 0 | |
| 0.00323 % | Northern Trust Investments, Inc. | 51,332 | 0 | |
| 0.00307 % | Wells Fargo Advisors | 48,900 | 8,200 | |
| 0.00263 % | Susquehanna International Group, LLP | 41,785 | 24,441 | |
| 0.00257 % | Wealth Enhancement Advisory Services, LLC | 40,816 | 30,000 | |
| 0.00231 % | COLUMBIA ADVISORY PARTNERS LLC | 36,730 | 0 | |
| 0.00189 % | Simon Quick Advisors, LLC | 30,000 | 0 | |
| 0.00173 % | SG Americas Securities, L.L.C. | 27,497 | 27,497 | |
| 0.00170 % | Legacy Capital Wealth Management, LLC | 27,080 | 27,080 | |
| 0.00152 % | Raymond James & Associates, Inc. | 24,218 | 0 | |
| 0.00150 % | Alleva (Lawrence M) | 23,894 | 0 | |
| 0.00145 % | Stifel, Nicolaus & Company, Incorporated | 23,007 | -3,462 | |
| 0.00143 % | J.P. Morgan Securities LLC | 22,782 | 22,782 | |
| 0.00126 % | Wiley Brothers-Aintree Capital, L.L.C. | 20,000 | 20,000 | |
| 0.00124 % | Prosperity Wealth Management, Inc. | 19,763 | -35 | |
| 0.00107 % | PKS Advisory Services, LLC | 17,000 | 17,000 | |
| 0.00101 % | Wood (Gavin) | 16,000 | 0 | |
| 0.00094 % | Baader Bank AG | 14,935 | 14,935 | |
| 0.00089 % | Morgan Stanley Smith Barney LLC | 14,118 | -73,432 | |
| 0.00084 % | Two Sigma Investments, LP | 13,304 | -329,375 | |
| 0.00078 % | Ausdal Financial Partners, Inc. | 12,476 | 0 | |
| 0.00078 % | Brewer (Joanna Elizabeth) | 12,442 | 0 | |
| 0.00074 % | IFG Advisory, LLC | 11,725 | 1,725 | |
| 0.00070 % | X-Square Capital, LLC | 11,173 | 0 | |
| 0.00069 % | Tower Research Capital LLC | 10,921 | -11,045 | |
| 0.00063 % | Kornitzer Capital Management Inc. | 10,000 | 0 | |
| 0.00054 % | Rhumbline Advisers Ltd. Partnership | 8,533 | -9,780 | |
| 0.00051 % | BlackRock Fund Advisors | 8,118 | 0 | |
| 0.00047 % | BlackRock Investment Management (UK) Ltd. | 7,423 | 0 | |
| 0.00041 % | Goldman Sachs Asset Management International | 6,547 | 0 | |
| 0.00029 % | Lindbrook Capital, LLC | 4,610 | 0 | |
| 0.00019 % | Blackstone Alternative Investment Advisors LLC | 3,021 | -700 | |
| 0.00016 % | Barclays Bank PLC | 2,527 | -47,534 | |
| 0.00015 % | UBS Switzerland AG | 2,406 | 2,406 | |
| 0.00007 % | Sandy Spring Bank | 1,050 | 0 | |
| 0.00007 % | Raymond James Financial Services Advisors, Inc. | 1,043 | 0 | |
| 0.00006 % | Plante Moran Financial Advisors, LLC | 925 | 0 | |
| 0.00006 % | Raiffeisen Bank International AG | 907 | 0 | |
| 0.00005 % | Desjardins Securities Inc. | 755 | 0 | |
| 0.00005 % | Garde Capital, Inc. | 750 | 750 | |
| 0.00004 % | Bryn Mawr Trust Company | 604 | 0 | |
| 0.00003 % | Carmichael Hill & Associates Inc | 525 | 0 | |
| 0.00002 % | HighMark Wealth Management LLC | 287 | 0 | |
| 0.00002 % | Parametric Portfolio Associates LLC | 285 | 0 | |
| 0.00002 % | Guggenheim Investments | 273 | 0 | |
| 0.00002 % | Parallel Advisors, LLC | 250 | 0 | |
| 0.00001 % | BNP Paribas Securities Corp. North America | 213 | 0 | |
| 0.00001 % | Transce3nd, LLC | 175 | 0 | |
| 0.00001 % | Northwestern Mutual Capital, LLC | 153 | 153 | |
| 0.00001 % | IRC Wealth | 100 | 0 | |
| 0.00000 % | Koesten, Hirschmann & Crabtree, Inc. | 47 | 47 | |
| 0.00000 % | TD Waterhouse Canada, Inc. | 14 | 0 | |
| 0.00000 % | SBI Securities Co., Ltd. | 10 | 0 | |
| 0.00000 % | Barclays Capital Inc. | 7 | 0 | |
| 0.00000 % | Northern Trust Global Investments | 1 | 0 | |
| 0 % | Procyon Advisors, LLC | 0 | -13,000 | |
| 0 % | ACCI Capital Investments SGIIC, SA | 0 | -221,290 | |
| 0 % | Qube Research & Technologies Ltd | 0 | -10,113 | |
| 0 % | Acuitas Investments LLC | 0 | -541,201 | |
| 0 % | Syncona Portfolio Ltd | 0 | -1,377,294 | |
| 0 % | Squarepoint Capital LLP | 0 | -16,563 | |
| 0 % | Independent Financial Partners | 0 | -3,023 | |
| 0 % | National Bank of Canada | 0 | -10 | |
| 0 % | Simplex Trading, LLC | 0 | -1,052 | |
| 0 % | HRT Financial LP | 0 | -83,199 | |