19,75881 % | BVF Partners L.P. | 8.748.629 | 0 | 31/12/2024 |
9,71157 % | Tang Capital Management, LLC | 4.300.000 | 0 | 31/12/2024 |
9,53438 % | BML Capital Management LLC | 4.221.546 | 38.323 | 31/12/2024 |
9,46143 % | Morgan Stanley & Co. LLC | 4.189.248 | 14.500 | 31/12/2024 |
5,10879 % | Soleus Capital Management, L.P. | 2.262.026 | -2.026.141 | 31/12/2024 |
4,99129 % | Opaleye Management Inc. | 2.209.998 | 2.209.998 | 31/12/2024 |
3,78299 % | Pfizer Inc | 1.675.000 | 1.675.000 | 31/12/2024 |
3,22514 % | Altium Capital Management LP | 1.428.000 | 1.428.000 | 31/12/2024 |
2,51372 % | RTW Investments L.P. | 1.113.002 | -2.148.494 | 31/12/2024 |
1,83461 % | BofA Global Research (US) | 812.310 | 812.302 | 31/12/2024 |
1,77158 % | Berger (Franklin Milan) | 784.404 | 0 | 8/1/2025 |
0,89781 % | Aldebaran Capital, LLC | 397.523 | 397.523 | 31/12/2024 |
0,69956 % | Two Sigma Investments, LP | 309.747 | 309.747 | 31/12/2024 |
0,60822 % | Medical Strategy GmbH | 269.304 | 0 | 31/8/2024 |
0,40928 % | Marshall Wace LLP | 181.217 | 181.217 | 31/12/2024 |
0,37174 % | BNP Paribas Securities Corp. North America | 164.595 | 120.100 | 31/12/2024 |
0,35919 % | Citadel Advisors LLC | 159.041 | 130.562 | 31/12/2024 |
0,21594 % | UBS Financial Services, Inc. | 95.614 | 93.197 | 31/12/2024 |
0,14853 % | Parkinson (David Ross M.D.) | 65.765 | 0 | 8/1/2025 |
0,12468 % | Magnus Financial Group LLC | 55.206 | 55.206 | 31/12/2024 |
0,11676 % | Glickman (Richard M) | 51.700 | -8460 | 8/1/2025 |
0,11293 % | Vazirani Asset Management LLC | 50.000 | 50.000 | 31/12/2024 |
0,11031 % | Schonfeld Strategic Advisors LLC | 48.843 | -229.157 | 31/12/2024 |
0,10473 % | American Century Investment Management, Inc. | 46.373 | -279 | 31/12/2024 |
0,10429 % | Avantis Investors | 46.176 | 26.132 | 31/3/2024 |
0,10346 % | Jane Street Capital, L.L.C. | 45.810 | 45.810 | 31/12/2024 |
0,08475 % | XTX Markets LLC | 37.526 | 37.526 | 31/12/2024 |
0,08209 % | Group One Trading, L.P. | 36.348 | 8553 | 31/12/2024 |
0,07587 % | Wood (David Sidney) | 33.593 | 250 | 8/1/2025 |
0,06821 % | Lepercq de Neuflize Asset Management, LLC | 30.200 | 30.200 | 31/12/2024 |
0,06821 % | Lepercq Corporation Management Ltd | 30.200 | 30.200 | 31/12/2024 |
0,06776 % | Requadt (Scott) | 30.002 | 0 | 8/1/2025 |
0,06066 % | Geode Capital Management, L.L.C. | 26.858 | 0 | 31/12/2024 |
0,05937 % | Cubist Systematic Strategies, LLC | 26.287 | 26.287 | 31/12/2024 |
0,05646 % | Prelude Capital Management, LLC | 25.000 | 25.000 | 31/12/2024 |
0,05646 % | FNY Investment Advisers LLC | 25.000 | 25.000 | 31/12/2024 |
0,03998 % | Susquehanna International Group, LLP | 17.704 | 17.704 | 31/12/2024 |
0,03636 % | Tucker Asset Management LLC | 16.097 | 16.097 | 31/3/2024 |
0,03543 % | Acadian Asset Management LLC | 15.687 | 15.687 | 31/12/2024 |
0,03280 % | Squarepoint Capital LLP | 14.525 | 14.525 | 31/12/2024 |
0,03214 % | Martin (John Alexander) | 14.229 | 0 | 8/1/2025 |
0,01756 % | Virsik (Peter) | 7776 | 0 | 8/1/2025 |
0,01445 % | Morgan Stanley Smith Barney LLC | 6400 | 0 | 31/12/2024 |
0,01355 % | Osaic Holdings, Inc. | 6000 | 0 | 31/12/2024 |
0,01316 % | BlackRock Financial Management, Inc. | 5826 | 217 | 31/12/2024 |
0,01157 % | Cesano (Alessandra) | 5124 | 0 | 8/1/2025 |
0,00915 % | Desjardins Securities Inc. | 4050 | 0 | 31/12/2024 |
0,00890 % | Truvestments Capital LLC | 3941 | 3095 | 31/12/2024 |
0,00651 % | Thorell (Marella) | 2881 | 0 | 8/1/2025 |
0,00565 % | CIBC Private Wealth Management | 2500 | 0 | 31/12/2024 |
0,00282 % | BlackRock Institutional Trust Company, N.A. | 1248 | 1248 | 31/12/2024 |
0,00203 % | TD Waterhouse Canada, Inc. | 900 | 0 | 31/12/2024 |
0,00175 % | RBC Dominion Securities, Inc. | 775 | 0 | 31/12/2024 |
0,00136 % | Laurel Wealth Advisors, LLC | 600 | 0 | 31/12/2024 |
0,00080 % | Barclays Bank PLC | 355 | 0 | 31/12/2024 |
0,00050 % | Morgan Stanley Canada Limited | 221 | 221 | 31/12/2024 |
0,00032 % | RBC Capital Markets Wealth Management | 143 | -39.879 | 31/12/2024 |
0,00005 % | J.P. Morgan Securities plc | 21 | 0 | 31/12/2024 |
0 % | Crewe Advisors LLC | 0 | -265 | 30/6/2023 |
0 % | Simplex Trading, LLC | 0 | -5162 | 31/12/2024 |
0 % | Blackstone Alternative Investment Advisors LLC | 0 | -800 | 31/12/2023 |
0 % | Hunting Hill Global Capital, LLC | 0 | -10.000 | 31/12/2023 |
0 % | Rock Springs Capital Management LP | 0 | -677.005 | 31/12/2024 |
0 % | Rhenman & Partners Asset Management AB | 0 | -804.649 | 31/12/2024 |
0 % | PFM Health Sciences, LP | 0 | -2.742.936 | 31/12/2024 |
0 % | Connective Capital Management, LLC | 0 | -84.578 | 31/12/2023 |
0 % | Tower Research Capital LLC | 0 | -27 | 30/9/2023 |
0 % | Northern Trust Global Investments | 0 | -4661 | 30/9/2023 |
0 % | TD Securities, Inc. | 0 | -48 | 30/9/2024 |
0 % | RBC Capital Partners | 0 | -537 | 30/9/2024 |
0 % | Bellevue Asset Management AG | 0 | -7.879.583 | 1/11/2024 |
0 % | Adage Capital Management, L.P. | 0 | -1.474.165 | 31/12/2024 |
0 % | Millennium Management LLC | 0 | -14.052 | 30/6/2024 |
0 % | Renaissance Technologies LLC | 0 | -24.234 | 31/3/2024 |
0 % | OrbiMed Advisors, LLC | 0 | -842.366 | 31/12/2023 |
0 % | D. E. Shaw & Co., L.P. | 0 | -62.955 | 31/12/2024 |
0 % | Driehaus Capital Management, LLC | 0 | -28.300 | 30/9/2023 |
0 % | Janus Henderson Investors | 0 | -1.006.202 | 30/9/2024 |
0 % | CIBC World Markets Inc. | 0 | -73.587 | 31/12/2024 |
0 % | Wellington Management Company, LLP | 0 | -562 | 30/6/2023 |
0 % | State Street Global Advisors (US) | 0 | -24.414 | 30/9/2023 |
0 % | Morgan Stanley Investment Management Inc. (US) | 0 | -7 | 30/6/2023 |
0 % | Bessemer Trust Company, N.A. (US) | 0 | -6852 | 30/6/2023 |
0 % | Northern Trust Investments, Inc. | 0 | -7828 | 30/9/2023 |
0 % | Kennedy Capital Management LLC | 0 | -41.092 | 31/12/2024 |
0 % | Parametric Portfolio Associates LLC | 0 | -194 | 31/12/2024 |
0 % | J.P. Morgan Securities LLC | 0 | -29.406 | 31/12/2023 |
0 % | Entrypoint Capital LLC | 0 | -4420 | 30/6/2024 |
0 % | Privium Fund Management (UK) Ltd | 0 | -20.032 | 31/3/2024 |
0 % | Ally Bridge Group NY LLC | 0 | -236.583 | 30/6/2023 |
0 % | Parkman Healthcare Partners LLC | 0 | -345.902 | 31/12/2024 |