10,79290 % | Baker Bros. Advisors LP | 4.257.735 | 1.579.182 | 31/3/2025 |
8,78594 % | BVF Partners L.P. | 3.466.000 | 0 | 31/3/2025 |
7,66754 % | Sullivan (Brian F) | 3.024.798 | 8155 | 14/4/2025 |
6,52512 % | Soleus Capital Management, L.P. | 2.574.122 | 9035 | 31/3/2025 |
5,98812 % | Perceptive Advisors LLC | 2.362.279 | 0 | 31/3/2025 |
5,13730 % | BlackRock Institutional Trust Company, N.A. | 2.026.633 | 10.036 | 31/3/2025 |
4,23895 % | The Vanguard Group, Inc. | 1.672.242 | 20.261 | 31/3/2025 |
3,20829 % | Eventide Asset Management, LLC | 1.265.653 | 0 | 31/3/2025 |
3,16862 % | New Enterprise Associates (NEA) | 1.250.001 | 0 | 31/3/2025 |
3,16862 % | Laing (Lance G Ph.D.) | 1.250.000 | 0 | 17/3/2025 |
2,77235 % | Saturn V Capital Management LP | 1.093.677 | 29.894 | 31/3/2025 |
2,40417 % | Citadel Advisors LLC | 948.429 | 112.406 | 31/3/2025 |
2,24162 % | Braidwell LP | 884.306 | 0 | 31/3/2025 |
2,02026 % | Janus Henderson Investors | 796.981 | 148.863 | 31/3/2025 |
1,82492 % | Geode Capital Management, L.L.C. | 719.920 | 27.548 | 31/3/2025 |
1,76340 % | Commodore Capital LP | 695.650 | 295.650 | 31/3/2025 |
1,54755 % | Vivo Capital, LLC | 610.500 | 0 | 31/3/2025 |
1,52720 % | Columbia Threadneedle Investments (US) | 602.472 | 155.301 | 31/3/2025 |
1,48337 % | State Street Global Advisors (US) | 585.180 | -294.612 | 31/3/2025 |
1,41346 % | CAPTRUST Financial Advisors | 557.603 | 95.809 | 31/3/2025 |
1,15248 % | Artisan Partners Limited Partnership | 454.646 | -36.861 | 31/3/2025 |
1,00331 % | Morgan Stanley Investment Management Inc. (US) | 395.800 | -55.830 | 31/3/2025 |
0,95143 % | Morgan Stanley & Co. LLC | 375.332 | 42.123 | 31/3/2025 |
0,93732 % | Candriam Luxembourg S.A. | 369.767 | 660 | 30/4/2025 |
0,88571 % | Pfizer Inc | 349.406 | 0 | 31/3/2025 |
0,72734 % | Northern Trust Investments, Inc. | 286.932 | -13.017 | 31/3/2025 |
0,66817 % | Candriam Belgium S.A. | 263.590 | 0 | 31/3/2025 |
0,63811 % | BofA Global Research (US) | 251.729 | -36.530 | 31/3/2025 |
0,59399 % | Dalvey David F | 234.325 | 0 | 17/3/2025 |
0,58819 % | Charles Schwab Investment Management, Inc. | 232.036 | -5670 | 31/3/2025 |
0,51024 % | Quantinno Capital Management LP | 201.286 | 201.286 | 31/3/2025 |
0,42774 % | Hennion & Walsh Asset Management, Inc. | 168.740 | 24.708 | 31/3/2025 |
0,25626 % | Nigon (Richard J) | 101.093 | 0 | 17/3/2025 |
0,21502 % | Wellington Management Company, LLP | 84.825 | 22.049 | 31/3/2025 |
0,20751 % | BlackRock Investment Management, LLC | 81.863 | 1299 | 31/3/2025 |
0,19582 % | Goldman Sachs & Company, Inc. | 77.248 | -30.418 | 31/3/2025 |
0,18632 % | BlackRock Financial Management, Inc. | 73.503 | 1607 | 31/3/2025 |
0,17640 % | Nuveen LLC | 69.587 | 0 | 31/3/2025 |
0,17298 % | UBS Financial Services, Inc. | 68.239 | -15.675 | 31/3/2025 |
0,16023 % | Jacob Asset Management of New York, LLC | 63.209 | -3000 | 30/9/2023 |
0,14781 % | Morgan Stanley Smith Barney LLC | 58.311 | -25.502 | 31/3/2025 |
0,13767 % | Gagnon Securities LLC | 54.310 | 1831 | 31/3/2025 |
0,13523 % | PFM Health Sciences, LP | 53.349 | -105.397 | 31/3/2025 |
0,13162 % | BNY Mellon Asset Management | 51.924 | 3394 | 31/3/2025 |
0,10696 % | Rhumbline Advisers Ltd. Partnership | 42.194 | 3439 | 31/3/2025 |
0,10147 % | Susquehanna International Group, LLP | 40.031 | 18.715 | 31/3/2025 |
0,09656 % | JNBA Financial Advisors LLC | 38.091 | 0 | 31/3/2025 |
0,09344 % | Bessemer Trust Company, N.A. (US) | 36.861 | -14.230 | 31/1/2025 |
0,08967 % | Barclays Bank PLC | 35.376 | -21.823 | 31/3/2025 |
0,08943 % | Two Sigma Investments, LP | 35.278 | -67.760 | 31/3/2025 |
0,07380 % | Accredited Investors Wealth Management | 29.115 | 0 | 31/3/2025 |
0,07302 % | Aperio Group, LLC | 28.806 | 20.592 | 31/3/2025 |
0,07300 % | Alps Advisors, Inc. | 28.798 | -1230 | 31/3/2025 |
0,07197 % | New York State Common Retirement Fund | 28.391 | 0 | 31/3/2025 |
0,06824 % | Trexquant Investment LP | 26.920 | 15.280 | 31/3/2025 |
0,06727 % | Wealth Enhancement Advisory Services, LLC | 26.539 | 162 | 31/3/2025 |
0,06258 % | Entrypoint Capital LLC | 24.687 | 3840 | 31/3/2025 |
0,06003 % | AllianceBernstein L.P. | 23.680 | 0 | 31/3/2025 |
0,05893 % | Citi Investment Research (US) | 23.247 | -15.561 | 31/3/2025 |
0,05472 % | Fubon Asset Management Company Ltd. | 21.588 | -155 | 28/2/2025 |
0,05396 % | Paloma Partners Management Company | 21.288 | 21.288 | 31/3/2025 |
0,05329 % | Commonwealth Financial Network | 21.024 | 21.024 | 31/3/2025 |
0,05159 % | Millennium Management LLC | 20.351 | -19.309 | 31/3/2025 |
0,05037 % | MetLife Investment Management, LLC | 19.872 | -512 | 31/3/2025 |
0,04908 % | Mirae Asset Global Investments (USA) LLC | 19.361 | -364 | 31/3/2025 |
0,04781 % | Hahne (Vicky) | 18.860 | 303 | 17/3/2025 |
0,04692 % | Cresset Asset Management, LLC | 18.510 | 0 | 31/3/2025 |
0,04634 % | DWS Investments UK Limited | 18.282 | -4028 | 31/3/2025 |
0,04472 % | Pale Fire Capital SE | 17.640 | 182 | 31/3/2025 |
0,04372 % | Trust Point Inc. | 17.247 | -600 | 31/3/2025 |
0,04269 % | Mellon Investments Corporation | 16.842 | 1247 | 31/3/2025 |
0,04061 % | Corebridge Financial Inc. | 16.019 | -237 | 31/3/2025 |
0,04021 % | Wells Fargo Bank, N.A. | 15.863 | 349 | 31/3/2025 |
0,03959 % | NEOS Investment Management, LLC | 15.619 | 116 | 31/3/2025 |
0,03920 % | JPMorgan Private Bank (United States) | 15.463 | 1084 | 31/3/2025 |
0,03625 % | Shay Capital LLC | 14.300 | 0 | 31/3/2025 |
0,03585 % | Numeric Investors LLC | 14.144 | 14.144 | 31/3/2025 |
0,03582 % | T. Rowe Price International Ltd | 14.132 | 1411 | 31/3/2025 |
0,03580 % | INTECH Investment Management LLC | 14.121 | -2528 | 31/3/2025 |
0,03300 % | Virtus Investment Advisers, Inc. | 13.020 | 13.020 | 31/3/2025 |
0,03061 % | Metropolitan Life Insurance Co. (US) | 12.075 | 12.075 | 31/3/2025 |
0,02998 % | Goldman Sachs Asset Management, L.P. | 11.825 | 1732 | 31/3/2025 |
0,02973 % | Manulife Investment Management (North America) Limited | 11.728 | 902 | 31/3/2025 |
0,02877 % | Perkins Capital Management, Inc. | 11.350 | 11.350 | 31/3/2025 |
0,02849 % | SG Americas Securities, L.L.C. | 11.240 | -3406 | 31/3/2025 |
0,02725 % | Furcht (Leo M.D.) | 10.750 | 0 | 17/3/2025 |
0,02710 % | Focus Financial Network, Inc. | 10.691 | 10.691 | 31/3/2025 |
0,02061 % | Harvest Fund Management Co., Ltd. | 8129 | 8129 | 31/12/2024 |
0,02020 % | RBC Capital Markets Wealth Management | 7969 | -372 | 31/3/2025 |
0,01954 % | Buller (Richard E) | 7710 | -50 | 27/5/2025 |
0,01820 % | Parametric Portfolio Associates LLC | 7179 | -943 | 31/3/2025 |
0,01662 % | Voya Investment Management LLC | 6558 | 0 | 30/4/2025 |
0,01635 % | Police and Firemen's Retirement System of New Jersey | 6451 | 0 | 31/3/2025 |
0,01444 % | ProShare Advisors LLC | 5698 | 183 | 31/5/2025 |
0,01364 % | Northern Trust Global Investments | 5380 | 172 | 31/3/2025 |
0,01267 % | Murphy (Polly A) | 5000 | 0 | 17/3/2025 |
0,01262 % | Florida State Board of Administration | 4980 | 0 | 31/3/2025 |
0,01068 % | Principal Global Investors (Equity) | 4213 | 621 | 30/4/2025 |
0,01015 % | Allspring Global Investments, LLC | 4006 | 0 | 30/4/2025 |
0,00952 % | BlackRock Advisors, LLC | 3756 | 833 | 31/12/2024 |