12,84798 % | Kynam Capital Management LP | 4.420.349 | 2.747.308 | 31/12/2022 |
10,54789 % | BVF Partners L.P. | 3.629.000 | 0 | 31/12/2022 |
5,55438 % | The Vanguard Group, Inc. | 1.910.984 | 69.214 | 31/12/2022 |
5,03528 % | Nantahala Capital Management, LLC | 1.732.388 | -54.771 | 31/12/2022 |
4,19048 % | Millennium Management LLC | 1.441.735 | 122.227 | 31/12/2022 |
4,04389 % | Citadel Advisors LLC | 1.391.302 | 269.873 | 31/12/2022 |
3,89565 % | Point72 Asset Management, L.P. | 1.340.300 | 1.069.700 | 31/12/2022 |
3,80289 % | BofA Global Research (US) | 1.308.386 | 4391 | 31/12/2022 |
3,76641 % | Ingalls & Snyder LLC (Asset Management) | 1.295.833 | -34.600 | 31/12/2022 |
3,49799 % | Parkman Healthcare Partners LLC | 1.203.484 | 65.897 | 31/12/2022 |
3,43564 % | BlackRock Institutional Trust Company, N.A. | 1.182.032 | 380.848 | 31/12/2022 |
3,34254 % | Tang Capital Management, LLC | 1.150.000 | 146.983 | 31/12/2022 |
3,16319 % | RA Capital Management, LP | 1.088.296 | 0 | 31/12/2022 |
2,91464 % | Sphera Funds Management Ltd. | 1.002.783 | 50.000 | 31/12/2022 |
2,84641 % | Medical Strategy GmbH | 979.309 | 0 | 30/9/2022 |
2,25235 % | Dimensional Fund Advisors, L.P. | 774.922 | 112.822 | 31/12/2022 |
2,23612 % | Assenagon Asset Management S.A. | 769.336 | -140.554 | 31/12/2022 |
2,18904 % | Acadian Asset Management LLC | 753.140 | 123.841 | 31/12/2022 |
1,93769 % | AWM Investment Company, Inc. | 666.661 | 0 | 31/12/2022 |
1,59324 % | Barclays Bank PLC | 548.155 | 97.922 | 31/12/2022 |
1,59134 % | NewEdge Wealth, LLC | 547.501 | 0 | 31/12/2022 |
1,57884 % | BMO Capital Markets (US) | 543.200 | 543.200 | 31/12/2022 |
1,56541 % | Alyeska Investment Group, L.P. | 538.579 | 38.579 | 31/12/2022 |
1,52196 % | Goldman Sachs & Company, Inc. | 523.630 | 189.551 | 31/12/2022 |
1,51077 % | Morgan Stanley & Co. LLC | 519.782 | -32.140 | 31/12/2022 |
1,46396 % | Schonfeld Strategic Advisors LLC | 503.674 | 244.574 | 31/12/2022 |
1,45504 % | Renaissance Technologies LLC | 500.605 | -142.000 | 31/12/2022 |
1,42742 % | Two Sigma Investments, LP | 491.105 | -365.147 | 31/12/2022 |
1,33749 % | IndexIQ Advisors LLC | 460.165 | 460.165 | 28/2/2023 |
1,21453 % | Geode Capital Management, L.L.C. | 417.858 | 9369 | 31/12/2022 |
0,84463 % | Connor, Clark & Lunn Investment Management Ltd. | 290.595 | -9763 | 31/12/2022 |
0,79709 % | J.P. Morgan Securities LLC | 274.240 | 186.915 | 31/12/2022 |
0,69813 % | Susquehanna International Group, LLP | 240.190 | 202.781 | 31/12/2022 |
0,61228 % | Stuart Nancy | 210.654 | -6048 | 15/2/2023 |
0,60028 % | Pura Vida Investments, LLC | 206.525 | 206.525 | 31/12/2022 |
0,58364 % | International Biotechnology Trust PLC | 200.800 | 0 | 31/12/2022 |
0,56413 % | Citi Investment Research (US) | 194.090 | 73.373 | 31/12/2022 |
0,44455 % | Manulife Investment Management (North America) Limited | 152.947 | 151.883 | 31/1/2023 |
0,43075 % | Bridgeway Capital Management, LLC | 148.200 | 0 | 31/12/2022 |
0,40953 % | State Street Global Advisors (US) | 140.898 | 20.300 | 31/12/2022 |
0,33091 % | D. E. Shaw & Co., L.P. | 113.848 | 113.848 | 31/12/2022 |
0,33018 % | Aberdeen Asset Managers Ltd. | 113.600 | -105.700 | 28/2/2023 |
0,31414 % | Northern Trust Investments, Inc. | 108.079 | -437 | 31/12/2022 |
0,30025 % | ClariVest Asset Management LLC | 103.300 | -1500 | 31/12/2022 |
0,29066 % | BZ Bank AG (Asset Management) | 100.000 | 0 | 30/11/2022 |
0,25694 % | Florida State Board of Administration | 88.400 | 88.400 | 30/9/2022 |
0,25677 % | Ensign Peak Advisors, Inc. | 88.341 | 0 | 31/12/2022 |
0,25345 % | City National Rochdale, LLC | 87.200 | 87.200 | 31/12/2022 |
0,24413 % | Caxton Associates LP | 83.993 | -40.122 | 31/12/2022 |
0,21668 % | Walleye Capital LLC | 74.548 | 74.548 | 31/12/2022 |
0,20637 % | Black Diamond Financial, LLC | 71.000 | 0 | 31/12/2022 |
0,20410 % | Morgan Stanley Smith Barney LLC | 70.221 | 0 | 31/12/2022 |
0,17466 % | BG Fund Management Luxembourg S.A. | 60.092 | 0 | 31/12/2022 |
0,17032 % | Kensington Investment Counsel, LLC | 58.599 | -18.202 | 31/12/2022 |
0,14278 % | RBF Capital, LLC | 49.122 | -15.781 | 31/12/2022 |
0,13701 % | Qube Research & Technologies Ltd | 47.137 | 13.399 | 31/12/2022 |
0,13419 % | Cubist Systematic Strategies, LLC | 46.167 | -26.901 | 31/12/2022 |
0,11401 % | Aldrich (Richard H) | 39.226 | -358.500 | 6/3/2023 |
0,11245 % | Cassella (James V) | 38.690 | -3762 | 15/2/2023 |
0,11062 % | 683 Capital Management LLC | 38.058 | 38.058 | 31/12/2022 |
0,10733 % | van Heek (Christine) | 36.926 | 26.926 | 9/6/2022 |
0,10289 % | Lake Street Advisors | 35.398 | 0 | 31/12/2022 |
0,09451 % | Alps Advisors, Inc. | 32.516 | 6319 | 31/12/2022 |
0,08926 % | BlackRock Advisors (UK) Limited | 30.710 | 8243 | 28/2/2023 |
0,08720 % | ACCI Capital Investments SGIIC, SA | 30.000 | -10.000 | 31/12/2022 |
0,08546 % | Jane Street Capital, L.L.C. | 29.404 | 18.992 | 31/12/2022 |
0,08491 % | Dimensional Fund Advisors, Ltd. | 29.215 | 4867 | 31/1/2023 |
0,08438 % | Marshall Wace LLP | 29.030 | 29.030 | 31/12/2022 |
0,08400 % | Auchincloss (Thomas G Jr) | 28.900 | 22.400 | 9/6/2022 |
0,08201 % | Apo Asset Management GmbH | 28.215 | 0 | 31/1/2023 |
0,07553 % | AHL Partners LLP | 25.987 | 25.987 | 31/12/2022 |
0,07097 % | Occudo Quantitative Strategies LP | 24.418 | -38.386 | 31/12/2022 |
0,07081 % | Hutt (Peter Barton) | 24.363 | 0 | 14/10/2022 |
0,07051 % | BlackRock Financial Management, Inc. | 24.259 | 8692 | 31/12/2022 |
0,06928 % | Barclays Capital Inc. | 23.835 | 21.314 | 31/12/2022 |
0,06589 % | BlackRock Asset Management Ireland Limited | 22.668 | 22.668 | 31/12/2022 |
0,06049 % | Northern Trust Global Investments | 20.813 | -5 | 31/12/2022 |
0,06030 % | Lighthouse Partners | 20.746 | 20.746 | 31/12/2022 |
0,05918 % | SG Americas Securities, L.L.C. | 20.361 | 3352 | 31/12/2022 |
0,05813 % | Birchview Capital, LP | 20.000 | 0 | 31/12/2022 |
0,05352 % | Boothbay Fund Management, LLC | 18.414 | 18.414 | 31/12/2022 |
0,05346 % | Becker (Marc A) | 18.392 | -3762 | 15/2/2023 |
0,05022 % | BNY Mellon Asset Management | 17.278 | 0 | 31/12/2022 |
0,04941 % | Alpine Associates Management Inc. | 17.000 | -17.700 | 28/2/2023 |
0,04767 % | Hoeiland (Jesper) | 16.400 | 16.400 | 9/6/2022 |
0,04767 % | Jaeger (Wilfred E) | 16.400 | 16.400 | 9/6/2022 |
0,04592 % | Acuitas Investments LLC | 15.800 | -600 | 31/12/2022 |
0,04559 % | Charles Schwab Investment Management, Inc. | 15.686 | 0 | 31/12/2022 |
0,04526 % | HSBC Global Asset Management (UK) Limited | 15.571 | 0 | 31/12/2022 |
0,04479 % | Tung (Roger D) | 15.411 | -814.343 | 6/3/2023 |
0,04479 % | Mirabella Financial Services LLP | 15.410 | 15.410 | 31/12/2022 |
0,04191 % | Jump Financial, LLC | 14.418 | -21.782 | 31/12/2022 |
0,03488 % | Cantor Fitzgerald, L.P | 12.000 | -30.100 | 31/12/2022 |
0,03008 % | Flagship Harbor Advisors LLC | 10.350 | 0 | 31/12/2022 |
0,02907 % | Roanoke Asset Management Corp. | 10.000 | 0 | 31/12/2022 |
0,02848 % | Blackstone Alternative Investment Advisors LLC | 9800 | 8000 | 30/9/2022 |
0,02323 % | Lord, Abbett & Co. LLC | 7992 | 0 | 31/1/2023 |
0,02323 % | BlackRock Investment Management, LLC | 7992 | 242 | 31/12/2022 |
0,02150 % | Tower Research Capital LLC | 7398 | 5351 | 31/12/2022 |
0,02122 % | UBS Financial Services, Inc. | 7301 | -6560 | 31/12/2022 |