| 3.48047 %  | Conifer Management LLC | 11,992,914 | 11,992,914 |  | 
| 3.48047 %  | Lombard Odier Asset Management (Europe) Ltd | 11,992,914 | 144,525 |  | 
| 1.68322 %  | Kamani (Umar Mahmud) | 5,800,000 | 0 |  | 
| 1.31494 %  | AXA Investment Managers UK Ltd. | 4,530,983 | 410 |  | 
| 1.24791 %  | Unicorn Asset Management Ltd. | 4,300,000 | 0 |  | 
| 0.82420 %  | Luckett (Nigel Frederick) | 2,840,000 | 0 |  | 
| 0.80745 %  | Avacta Group Plc Employees' Share Trust | 2,782,306 | 0 |  | 
| 0.80540 %  | Muir (Andrew Hugh John) | 2,775,219 | 0 |  | 
| 0.58957 %  | Robbins (Sheldon Bryan) | 2,031,537 | 10,593 |  | 
| 0.53863 %  | Dawes (P R) | 1,856,002 | -160,000 |  | 
| 0.43288 %  | Macwhirter (Andrew) | 1,491,596 | -318,127 |  | 
| 0.40920 %  | Mr Nicholas Mallett & Mrs Alis | 1,410,000 | 10,000 |  | 
| 0.31373 %  | Hashmat (S) | 1,081,032 | 143,880 |  | 
| 0.30701 %  | Garton (Stephen) | 1,057,882 | 617,119 |  | 
| 0.25163 %  | University of Leeds | 867,070 | 0 |  | 
| 0.24668 %  | Frost (J) | 850,000 | 0 |  | 
| 0.24526 %  | McCord (Peter Nicholas George) | 845,128 | 187,628 |  | 
| 0.24160 %  | Beautement (M) | 832,500 | 7,500 |  | 
| 0.23741 %  | Mitchell (Mark) | 818,055 | 0 |  | 
| 0.23125 %  | Eaton (Mark Christopher Bromley) | 796,825 | 104,332 |  | 
| 0.22004 %  | Legal & General Investment Management Ltd. | 758,204 | 607,604 |  | 
| 0.20382 %  | Mayhew-Sanders (Nick) | 702,312 | 544,466 |  | 
| 0.20374 %  | Walton (Paul) | 702,044 | 490,582 |  | 
| 0.20352 %  | Gray (Andrew) | 701,275 | 701,275 |  | 
| 0.20315 %  | Mallett (Nicholas John) | 700,000 | 160,000 |  | 
| 0.19716 %  | Raynor (Jonathan) | 679,364 | -2,537 |  | 
| 0.18620 %  | Sutton (William) | 641,599 | 22,000 |  | 
| 0.18448 %  | Ive (T) | 635,682 | -23,487 |  | 
| 0.18193 %  | Baldwin (Kurt Justin) | 626,880 | 61,185 |  | 
| 0.17413 %  | Hislop (John) | 600,000 | 285,000 |  | 
| 0.16125 %  | Tandon (Anand Prakash) | 555,634 | 555,634 |  | 
| 0.16020 %  | Fidelity Management & Research Company LLC | 551,997 | 166,677 |  | 
| 0.15919 %  | Kendall (James) | 548,529 | 112,606 |  | 
| 0.15910 %  | De Courcey (Adrian) | 548,230 | 0 |  | 
| 0.15686 %  | Sanham (Nicholas) | 540,500 | 0 |  | 
| 0.15580 %  | Fraser (Ross) | 536,867 | 37,605 |  | 
| 0.15552 %  | Stevens (Sarah) | 535,881 | 0 |  | 
| 0.15228 %  | Freeman (David) | 524,739 | 0 |  | 
| 0.15068 %  | Gill (M) | 519,214 | 133,000 |  | 
| 0.14921 %  | Coyle (Anthony) | 514,161 | 15,311 |  | 
| 0.14888 %  | Chadwick (Iain) | 513,023 | 222,522 |  | 
| 0.14872 %  | Pitt (Craig) | 512,467 | 219,434 |  | 
| 0.14511 %  | Neue Bank AG | 500,000 | 0 |  | 
| 0.14212 %  | Sedani (Sachin) | 489,715 | 489,715 |  | 
| 0.14118 %  | Dutia (Miten) | 486,463 | 59,037 |  | 
| 0.14114 %  | Keen (Cheryl Linda) | 486,327 | -239 |  | 
| 0.13950 %  | Reidy (David) | 480,700 | 0 |  | 
| 0.13261 %  | Jones (Timothy Wyn) | 456,948 | 272,203 |  | 
| 0.13091 %  | Smith (Alastair) | 451,100 | 0 |  | 
| 0.13059 %  | Kamani (Nurez Abdullah) | 450,000 | 0 |  | 
| 0.12944 %  | Medical Research Council | 446,010 | 0 |  | 
| 0.12922 %  | Read (Simon David) | 445,274 | 0 |  | 
| 0.12913 %  | Farmer (E) | 444,948 | 64,890 |  | 
| 0.12384 %  | Radclyffe (Kenneth) | 426,708 | 3,265 |  | 
| 0.12360 %  | Bhoopongsa (N) | 425,904 | 0 |  | 
| 0.12232 %  | Longden (C) | 421,495 | 0 |  | 
| 0.11904 %  | Fawcett (A M) | 410,188 | 5,965 |  | 
| 0.11779 %  | Hogg (Walter) | 405,864 | 40,324 |  | 
| 0.11708 %  | White (A) | 403,441 | 0 |  | 
| 0.11608 %  | Clarke (B) | 400,000 | 0 |  | 
| 0.11405 %  | Jordan (Philip) | 393,001 | 2,398 |  | 
| 0.11387 %  | Lennon (Selena) | 392,368 | 36,065 |  | 
| 0.11279 %  | McCord (Victoria Elizabeth Rose) | 388,653 | 176,642 |  | 
| 0.11254 %  | Laycock (Jeremy) | 387,772 | 141,587 |  | 
| 0.11173 %  | Churchlow (Robert) | 385,000 | -32,500 |  | 
| 0.10996 %  | Shelley (M J) | 378,905 | 31,288 |  | 
| 0.10883 %  | Piccou (Vasilis Vangelis) | 375,000 | 65,000 |  | 
| 0.10805 %  | Rathbones Investment Management Limited | 372,327 | 27,757 |  | 
| 0.10709 %  | Meier (Ed) | 369,011 | 0 |  | 
| 0.10635 %  | Spence (Michael) | 366,472 | 172,447 |  | 
| 0.10617 %  | Mitchell (Bridget) | 365,847 | 13,973 |  | 
| 0.10509 %  | Inglis (John) | 362,123 | -281,141 |  | 
| 0.10375 %  | Grace (Nicholas) | 357,500 | 117,500 |  | 
| 0.10349 %  | Meier (Sarah) | 356,593 | 148,453 |  | 
| 0.10347 %  | Sciama (Robert) | 356,534 | 0 |  | 
| 0.10329 %  | Williamson (Nigel) | 355,910 | -24,287 |  | 
| 0.10299 %  | Esmail (Arif) | 354,896 | 0 |  | 
| 0.10279 %  | Williams (R) | 354,204 | 0 |  | 
| 0.10276 %  | White (Patrick William) | 354,087 | -33,320 |  | 
| 0.10129 %  | McAteer (David) | 349,028 | 260,240 |  | 
| 0.10090 %  | Stevens (David) | 347,678 | 0 |  | 
| 0.10056 %  | Bielski (Jan Wiktor) | 346,500 | 8,750 |  | 
| 0.09755 %  | O'Neill (J) | 336,126 | 51,416 |  | 
| 0.09742 %  | Williams (Duncan Bryn) | 335,691 | 0 |  | 
| 0.09674 %  | Bamber (Andrew William John) | 333,334 | 333,334 |  | 
| 0.09674 %  | Thornton (Tony Alan) | 333,333 | 0 |  | 
| 0.09576 %  | Mc-William (Andrew David) | 329,967 | 84,901 |  | 
| 0.09380 %  | Denbigh (Paul) | 323,228 | 20,575 |  | 
| 0.09287 %  | Airey (Peter David) | 320,000 | 0 |  | 
| 0.09240 %  | Coath (A) | 318,393 | 318,393 |  | 
| 0.09118 %  | Thomas (T) | 314,193 | 314,193 |  | 
| 0.09084 %  | Sprung (Peter) | 313,017 | 60,000 |  | 
| 0.08986 %  | Bowman (Ian) | 309,643 | 135,366 |  | 
| 0.08954 %  | Wilding (Robert William) | 308,521 | 104,077 |  | 
| 0.08939 %  | Mrs A Hood & Mrs E Nayar | 308,034 | -22,441 |  | 
| 0.08845 %  | Thomas (Linda Sharon) | 304,776 | -20,913 |  | 
| 0.08833 %  | Flack (Steven) | 304,379 | 138,794 |  | 
| 0.08811 %  | Coutts & Co. | 303,606 | 59,600 |  | 
| 0.08706 %  | Coffey (P) | 300,000 | 3,676 |  | 
| 0.08667 %  | Craig (Alastair John Gilchrist) | 298,633 | 10,000 |  |