| 8,20479 %  | Fidelity Management & Research Company LLC | 6.217.592 | 593.984 | 30.6.2025 | 
| 5,65051 %  | Paradigm BioCapital Advisors LP | 4.281.954 | 727.895 | 30.6.2025 | 
| 5,27917 %  | RTW Investments L.P. | 4.000.553 | -168.840 | 30.6.2025 | 
| 4,91782 %  | Wellington Management Company, LLP | 3.726.723 | -991.449 | 30.6.2025 | 
| 4,65162 %  | Commodore Capital LP | 3.525.000 | -947.840 | 30.6.2025 | 
| 4,46639 %  | Deerfield Management Company, L.P. | 3.384.628 | 210.700 | 30.6.2025 | 
| 4,16410 %  | Avoro Capital Advisors LLC | 3.155.555 | 155.555 | 30.6.2025 | 
| 2,98497 %  | T. Rowe Price Associates, Inc. | 2.262.011 | 1.166.269 | 30.6.2025 | 
| 2,93645 %  | Holocene Advisors, LP | 2.225.241 | 351.616 | 30.6.2025 | 
| 2,69515 %  | Westfield Capital Management Company, L.P. | 2.042.388 | 541.168 | 30.6.2025 | 
| 2,34743 %  | Franklin Advisers, Inc. | 1.778.885 | -158.367 | 30.6.2025 | 
| 2,12596 %  | Polar Capital LLP | 1.611.049 | -95.813 | 30.6.2025 | 
| 2,07026 %  | Lynx1 Capital Advisors LLC | 1.568.841 | 0 | 30.6.2025 | 
| 2,03603 %  | Woodline Partners LP | 1.542.900 | 142.729 | 30.6.2025 | 
| 2,01714 %  | Federated Hermes Global Investment Management Corp. | 1.528.587 | 483.962 | 30.6.2025 | 
| 1,80291 %  | Driehaus Capital Management, LLC | 1.366.244 | 112.095 | 30.6.2025 | 
| 1,67958 %  | Fidelity Institutional Asset Management | 1.272.785 | -70.521 | 30.6.2025 | 
| 1,47917 %  | Columbia Threadneedle Investments (US) | 1.120.913 | 1.023.894 | 30.6.2025 | 
| 1,47796 %  | Cormorant Asset Management, LP | 1.120.000 | 380.000 | 30.6.2025 | 
| 1,45468 %  | AllianceBernstein L.P. | 1.102.356 | 363.068 | 30.6.2025 | 
| 1,40355 %  | Rock Springs Capital Management LP | 1.063.608 | 82.857 | 30.6.2025 | 
| 1,33027 %  | Incyte Corp | 1.008.076 | -2.996.468 | 30.6.2024 | 
| 1,20778 %  | Pictet Asset Management Ltd. | 915.252 | -116.849 | 30.6.2025 | 
| 1,12624 %  | Invus Public Equities Advisors, LLC | 853.467 | -190.000 | 30.6.2025 | 
| 1,09976 %  | Adage Capital Management, L.P. | 833.397 | 833.397 | 30.6.2025 | 
| 1,09469 %  | Janus Henderson Investors | 829.558 | 447.747 | 30.6.2025 | 
| 1,00975 %  | Samlyn Capital, LLC | 765.185 | -1.614.243 | 30.6.2025 | 
| 0,98971 %  | Novo Holdings A/S | 750.000 | -39.129 | 30.6.2025 | 
| 0,98889 %  | Invesco Advisers, Inc. | 749.384 | -16.046 | 30.6.2025 | 
| 0,97911 %  | SilverArc Capital Management, LLC | 741.972 | -69.049 | 30.6.2025 | 
| 0,93452 %  | Perceptive Advisors LLC | 708.176 | 17.691 | 30.6.2025 | 
| 0,86698 %  | Caligan Partners, LP | 656.999 | 280.045 | 30.6.2025 | 
| 0,79177 %  | Tang Capital Management, LLC | 600.000 | 500.000 | 30.6.2025 | 
| 0,75795 %  | Baker Bros. Advisors LP | 574.377 | 350.877 | 30.6.2025 | 
| 0,74003 %  | UBS Financial Services, Inc. | 560.794 | -292.290 | 30.6.2025 | 
| 0,69638 %  | Candriam Luxembourg S.A. | 527.716 | -1.166 | 30.9.2025 | 
| 0,69567 %  | Medical Strategy GmbH | 527.176 | 0 | 31.7.2025 | 
| 0,64825 %  | Capital International Investors | 491.244 | 491.244 | 30.6.2025 | 
| 0,60993 %  | BlackRock Institutional Trust Company, N.A. | 462.208 | -20.130 | 30.6.2025 | 
| 0,60209 %  | T. Rowe Price Investment Management, Inc. | 456.265 | -53.496 | 30.6.2025 | 
| 0,59716 %  | Gilead Sciences Inc | 452.527 | 0 | 30.6.2025 | 
| 0,53386 %  | Sofinnova Investments, Inc | 404.562 | 404.562 | 30.6.2025 | 
| 0,52627 %  | Dafna Capital Management, LLC | 398.804 | -63.000 | 30.6.2025 | 
| 0,52222 %  | Darwin Global Management Ltd | 395.738 | 395.738 | 30.6.2025 | 
| 0,51333 %  | Octagon Capital Advisors LP | 389.000 | 81.000 | 30.6.2025 | 
| 0,51017 %  | Morgan Stanley Investment Management Inc. (US) | 386.606 | 279.184 | 30.6.2025 | 
| 0,50415 %  | JPMorgan Asset Management U.K. Limited | 382.048 | 382.048 | 30.6.2025 | 
| 0,48166 %  | Boxer Capital Management, LLC | 365.000 | -335.000 | 30.6.2025 | 
| 0,45210 %  | Handelsbanken Kapitalförvaltning AB | 342.600 | 49.300 | 30.9.2025 | 
| 0,44285 %  | Citadel Advisors LLC | 335.594 | 308.605 | 30.6.2025 | 
| 0,41422 %  | Two Sigma Investments, LP | 313.894 | -566.367 | 30.6.2025 | 
| 0,40120 %  | J.P. Morgan Securities LLC | 304.032 | 13.315 | 30.6.2025 | 
| 0,39159 %  | Artia Global Partners LP | 296.750 | -127.890 | 30.6.2025 | 
| 0,38660 %  | First Turn Management, LLC | 292.964 | -170.996 | 30.6.2025 | 
| 0,37807 %  | BlackRock Financial Management, Inc. | 286.501 | -547.164 | 30.6.2025 | 
| 0,36289 %  | Deep Track Capital LP | 275.000 | 275.000 | 30.6.2025 | 
| 0,36006 %  | Boothbay Fund Management, LLC | 272.855 | 112.855 | 30.6.2025 | 
| 0,35114 %  | StemPoint Capital LP | 266.094 | -80.662 | 30.6.2025 | 
| 0,33595 %  | The Vanguard Group, Inc. | 254.586 | 6.396 | 30.6.2025 | 
| 0,32738 %  | JPMorgan Asset Management (Europe) S.à.r.l. | 248.085 | -143.036 | 30.9.2025 | 
| 0,32027 %  | TimesSquare Capital Management, LLC | 242.698 | -101.007 | 30.6.2025 | 
| 0,31818 %  | State Street Investment Management (US) | 241.116 | 8.366 | 30.6.2025 | 
| 0,30176 %  | BlackRock Advisors (UK) Limited | 228.670 | 5.199 | 30.9.2025 | 
| 0,29823 %  | Lord, Abbett & Co. LLC | 226.001 | 226.001 | 30.6.2025 | 
| 0,29594 %  | Saturn V Capital Management LP | 224.260 | -98.951 | 30.6.2025 | 
| 0,28335 %  | Carmignac Gestion | 214.722 | 93.561 | 30.6.2025 | 
| 0,27752 %  | Voya Investment Management LLC | 210.304 | -23.167 | 30.9.2025 | 
| 0,26837 %  | BlackRock Asset Management Ireland Limited | 203.370 | 20.948 | 30.6.2025 | 
| 0,26226 %  | Lundberg (Sven Ante) | 198.740 | 70.898 | 18.4.2025 | 
| 0,24954 %  | Decheng Capital LLC | 189.098 | 0 | 30.6.2025 | 
| 0,24265 %  | PFM Health Sciences, LP | 183.882 | 183.882 | 30.6.2025 | 
| 0,23753 %  | Impax Asset Management LLC | 180.000 | 0 | 30.6.2025 | 
| 0,22536 %  | Point72 Asset Management, L.P. | 170.777 | 170.777 | 30.6.2025 | 
| 0,21823 %  | UBS Asset Management (Switzerland) | 165.374 | 117.859 | 30.6.2025 | 
| 0,21507 %  | Parkman Healthcare Partners LLC | 162.980 | 134.750 | 30.6.2025 | 
| 0,21125 %  | Goldman Sachs Asset Management, L.P. | 160.089 | 4.301 | 30.9.2025 | 
| 0,19839 %  | Nan Fung Trinity (HK) Limited | 150.338 | 150.338 | 30.6.2025 | 
| 0,19734 %  | State of Wisconsin Investment Board | 149.543 | -8.765 | 30.6.2025 | 
| 0,19517 %  | D. E. Shaw & Co., L.P. | 147.902 | 96.885 | 30.6.2025 | 
| 0,18502 %  | Ally Bridge Group NY LLC | 140.208 | 62.312 | 30.6.2025 | 
| 0,17495 %  | BNP Paribas Securities Corp. North America | 132.576 | 130.987 | 30.6.2025 | 
| 0,17277 %  | Eversept Partners, LP | 130.924 | 60.595 | 30.6.2025 | 
| 0,16596 %  | abrdn Inc. | 125.768 | -46.295 | 30.6.2025 | 
| 0,16495 %  | Alyeska Investment Group, L.P. | 125.000 | 56.818 | 30.6.2025 | 
| 0,15447 %  | CenterBook Partners LP | 117.056 | 25.968 | 30.6.2025 | 
| 0,15307 %  | Rhenman & Partners Asset Management AB | 116.000 | 41.500 | 30.6.2025 | 
| 0,14706 %  | Victory Capital Management Inc. | 111.440 | 102.160 | 30.6.2025 | 
| 0,14516 %  | DWS Investment GmbH | 110.000 | 0 | 30.6.2025 | 
| 0,14069 %  | Goldman Sachs & Company, Inc. | 106.618 | -18.177 | 30.6.2025 | 
| 0,13002 %  | ExodusPoint Capital Management, LP | 98.529 | 52.905 | 30.6.2025 | 
| 0,12599 %  | MFS Investment Management | 95.472 | -4.132 | 31.8.2025 | 
| 0,12187 %  | Schweizerische Nationalbank | 92.354 | -500 | 30.6.2025 | 
| 0,12182 %  | BofA Global Research (US) | 92.314 | 48.229 | 30.6.2025 | 
| 0,11845 %  | HighVista Strategies LLC | 89.762 | 34.723 | 30.6.2025 | 
| 0,11759 %  | TD Asset Management Inc. | 89.110 | 17.852 | 30.6.2025 | 
| 0,10639 %  | Granahan Investment Management, LLC | 80.619 | -15.101 | 30.6.2025 | 
| 0,10368 %  | Invesco Capital Management LLC | 78.566 | 21.080 | 30.6.2025 | 
| 0,10359 %  | Readystate Asset Management LP | 78.500 | 78.500 | 30.6.2025 | 
| 0,10278 %  | Allianz Global Investors GmbH | 77.890 | -9.095 | 31.8.2025 | 
| 0,10088 %  | Moody Aldrich Partners, LLC | 76.444 | -15.565 | 30.9.2025 |