| 8,37375 % | RTW Investments L.P. | 5.158.231 | 892.803 | 30.6.2025 |
| 6,47560 % | EcoR1 Capital, LLC | 3.988.971 | 0 | 30.6.2025 |
| 6,00649 % | Vestal Point Capital, LP | 3.700.000 | -1.092.572 | 30.6.2025 |
| 5,88474 % | Avoro Capital Advisors LLC | 3.625.000 | 1.450.000 | 30.6.2025 |
| 4,77231 % | abrdn Inc. | 2.939.743 | 189.029 | 30.9.2025 |
| 3,87680 % | Bristol Myers Squibb | 2.388.108 | 0 | 30.9.2024 |
| 3,40249 % | Jefferies LLC | 2.095.931 | 2.095.931 | 30.6.2025 |
| 3,33093 % | Nantahala Capital Management, LLC | 2.051.852 | -704.110 | 30.6.2025 |
| 2,60613 % | Franklin Advisers, Inc. | 1.605.378 | -382.310 | 30.6.2025 |
| 2,59847 % | Two Sigma Investments, LP | 1.600.660 | 15.667 | 30.6.2025 |
| 2,52980 % | Sofinnova Investments, Inc | 1.558.356 | 1.012.585 | 30.6.2025 |
| 2,19156 % | Integral Health Asset Management, LLC | 1.350.000 | 100.000 | 30.6.2025 |
| 2,17476 % | JP Morgan Asset Management | 1.339.651 | 1.339.528 | 30.6.2025 |
| 2,08604 % | 683 Capital Management LLC | 1.285.000 | -265.000 | 30.6.2025 |
| 2,03456 % | BlackRock Institutional Trust Company, N.A. | 1.253.286 | -53.870 | 30.6.2025 |
| 1,85521 % | State Street Investment Management (US) | 1.142.810 | -86.779 | 30.6.2025 |
| 1,62254 % | Jennison Associates LLC | 999.484 | 859.424 | 30.9.2025 |
| 1,56413 % | The Vanguard Group, Inc. | 963.501 | 18.035 | 30.6.2025 |
| 1,46023 % | Boxer Capital Management, LLC | 899.500 | 149.500 | 30.6.2025 |
| 1,30293 % | Fidelity Management & Research Company LLC | 802.607 | -47.042 | 30.6.2025 |
| 1,23693 % | Columbia Threadneedle Investments (US) | 761.948 | 212.218 | 30.6.2025 |
| 1,18611 % | Medical Strategy GmbH | 730.646 | 0 | 31.7.2025 |
| 1,14637 % | Macquarie Investment Management | 706.166 | 0 | 30.6.2025 |
| 1,12546 % | Schroder Investment Management Ltd. (SIM) | 693.283 | -496.838 | 30.6.2025 |
| 0,99226 % | Morgan Stanley & Co. LLC | 611.235 | 404.117 | 30.6.2025 |
| 0,97924 % | Geode Capital Management, L.L.C. | 603.210 | -7.761 | 30.6.2025 |
| 0,92957 % | StemPoint Capital LP | 572.615 | -158.424 | 30.6.2025 |
| 0,90238 % | Citadel Advisors LLC | 555.865 | -229.455 | 30.6.2025 |
| 0,87170 % | Balyasny Asset Management LP | 536.968 | 512.040 | 30.6.2025 |
| 0,86006 % | Pale Fire Capital SE | 529.798 | 67.439 | 30.6.2025 |
| 0,81765 % | BNP Paribas Securities Corp. North America | 503.672 | 22.222 | 30.6.2025 |
| 0,72644 % | Privium Fund Management BV | 447.486 | -131.653 | 30.6.2025 |
| 0,71984 % | Parkman Healthcare Partners LLC | 443.422 | 239.589 | 30.6.2025 |
| 0,70107 % | JPMorgan Asset Management U.K. Limited | 431.859 | 163.081 | 30.6.2025 |
| 0,68093 % | Kapusta Matthew C | 419.453 | 0 | 24.9.2025 |
| 0,67767 % | Catalio Capital Management, LP | 417.443 | -412.882 | 30.6.2025 |
| 0,61973 % | Fidelity Institutional Asset Management | 381.755 | 30.460 | 30.6.2025 |
| 0,57867 % | Goldman Sachs & Company, Inc. | 356.463 | 96.826 | 30.6.2025 |
| 0,47554 % | Charles Schwab Investment Management, Inc. | 292.931 | 12.932 | 30.6.2025 |
| 0,37999 % | UBS Financial Services, Inc. | 234.076 | 34.727 | 30.6.2025 |
| 0,36198 % | Marshall Wace LLP | 222.979 | 163.749 | 30.6.2025 |
| 0,34284 % | Morgan Stanley Investment Management Inc. (US) | 211.188 | -62.299 | 30.6.2025 |
| 0,33604 % | Avidity Partners Management LP | 207.000 | -129.200 | 30.6.2025 |
| 0,32884 % | SilverArc Capital Management, LLC | 202.565 | -835 | 30.6.2025 |
| 0,32482 % | Mellon Investments Corporation | 200.088 | 198.512 | 30.6.2025 |
| 0,28719 % | Caption Management, LLC | 176.911 | 156.552 | 30.6.2025 |
| 0,28572 % | Squarepoint Capital LLP | 176.002 | -2.330 | 30.6.2025 |
| 0,28540 % | Woodline Partners LP | 175.806 | 0 | 30.6.2025 |
| 0,28409 % | Moore Capital Management, LP | 175.000 | 25.000 | 30.6.2025 |
| 0,28300 % | PFM Health Sciences, LP | 174.331 | -425.636 | 30.6.2025 |
| 0,28209 % | Caloz (Pierre Alain) | 173.769 | 139.958 | 31.3.2025 |
| 0,26900 % | Invesco Capital Management LLC | 165.703 | -319.602 | 30.6.2025 |
| 0,24056 % | Hudson Bay Capital Management LP | 148.182 | -3.518 | 30.6.2025 |
| 0,22068 % | BofA Global Research (US) | 135.939 | -244.913 | 30.6.2025 |
| 0,21916 % | Affinity Asset Advisors LLC | 135.000 | -265.000 | 30.6.2025 |
| 0,21907 % | Schonfeld Strategic Advisors LLC | 134.948 | 92.801 | 30.6.2025 |
| 0,21536 % | Millennium Management LLC | 132.664 | -133.002 | 30.6.2025 |
| 0,20292 % | Voss Capital LLC | 125.000 | 125.000 | 30.6.2025 |
| 0,19478 % | Ikarian Capital LLC | 119.986 | 119.986 | 30.6.2025 |
| 0,18125 % | Newton Investment Management North America, LLC | 111.648 | 111.648 | 30.6.2025 |
| 0,17454 % | Northern Trust Investments, Inc. | 107.516 | 10.740 | 30.6.2025 |
| 0,17287 % | Russell Investments Trust Company | 106.490 | -197.142 | 30.6.2025 |
| 0,17198 % | Point72 Asset Management, L.P. | 105.939 | -24.136 | 30.6.2025 |
| 0,17192 % | T. Rowe Price Associates, Inc. | 105.900 | 105.900 | 30.9.2025 |
| 0,16579 % | Voya Investment Management LLC | 102.124 | 34.864 | 30.9.2025 |
| 0,16134 % | Shay Capital LLC | 99.383 | 17.534 | 30.6.2025 |
| 0,16114 % | Klemt (Christian) | 99.261 | 0 | 26.9.2025 |
| 0,16022 % | Birchview Capital, LP | 98.697 | 10.000 | 30.6.2025 |
| 0,15031 % | Verition Fund Management LLC | 92.591 | -3.943 | 30.6.2025 |
| 0,14450 % | Barclays Bank PLC | 89.014 | 59.653 | 30.6.2025 |
| 0,14132 % | Sanders Morris LLC | 87.054 | 87.054 | 30.9.2025 |
| 0,13418 % | Diamond Hill Capital Management Inc. | 82.653 | 0 | 30.6.2025 |
| 0,12958 % | Parametric Portfolio Associates LLC | 79.820 | -10.333 | 30.6.2025 |
| 0,12855 % | UBS Asset Management (Switzerland) | 79.184 | 79.184 | 30.6.2025 |
| 0,12581 % | Schweizerische Nationalbank | 77.500 | 77.500 | 30.6.2025 |
| 0,12580 % | SummitTX Capital, L.P. | 77.495 | 77.495 | 30.6.2025 |
| 0,11364 % | Monaco asset management S.A.M. | 70.000 | -5.000 | 30.6.2025 |
| 0,11355 % | BlackRock Advisors (UK) Limited | 69.946 | 5.327 | 30.9.2025 |
| 0,11170 % | Rafferty Asset Management LLC | 68.807 | -13.782 | 30.6.2025 |
| 0,10915 % | RBC Capital Markets Wealth Management | 67.235 | 18.052 | 30.6.2025 |
| 0,10874 % | Stifel, Nicolaus & Company, Incorporated | 66.981 | 11.213 | 30.6.2025 |
| 0,10432 % | Simplex Trading, LLC | 64.259 | 16.735 | 30.6.2025 |
| 0,10338 % | Group One Trading, L.P. | 63.681 | 60.136 | 30.6.2025 |
| 0,10304 % | UBS O'Connor LLC | 63.475 | -51.414 | 30.6.2025 |
| 0,09723 % | International Asset Management Limited | 59.891 | -46.410 | 30.4.2025 |
| 0,09159 % | Main Management ETF Advisors, LLC | 56.420 | 912 | 30.6.2025 |
| 0,09002 % | Sectoral Asset Management Inc. | 55.450 | -2.100 | 30.6.2025 |
| 0,08379 % | Hennion & Walsh Asset Management, Inc. | 51.613 | 21.244 | 30.9.2025 |
| 0,08338 % | Bellecapital AG | 51.363 | 0 | 31.1.2025 |
| 0,08187 % | Jane Street Capital, L.L.C. | 50.430 | 13.034 | 30.6.2025 |
| 0,08117 % | Sonic GP LLC | 50.000 | 0 | 31.12.2024 |
| 0,08117 % | Centiva Capital, LP | 50.000 | 50.000 | 30.6.2025 |
| 0,08051 % | Fred Alger Management, LLC | 49.592 | 49.592 | 30.9.2025 |
| 0,07838 % | Susquehanna International Group, LLP | 48.283 | 6.936 | 30.6.2025 |
| 0,07737 % | Gut (Robert) | 47.659 | 4.634 | 20.6.2025 |
| 0,06890 % | Headlands Technologies LLC | 42.444 | 31.948 | 30.6.2025 |
| 0,06705 % | Erste Asset Management GmbH | 41.300 | 0 | 31.7.2025 |
| 0,06494 % | Massar Capital Management, LP | 40.000 | 0 | 30.6.2025 |
| 0,06384 % | Mirae Asset Global Investments (USA) LLC | 39.328 | -33.508 | 30.6.2025 |
| 0,06284 % | California State Teachers Retirement System | 38.707 | 38.707 | 30.6.2025 |